Crosslinked Polyphosphazene Nanospheres with Anticancer Quercetin: Synthesis, Spectroscopic, Thermal Properties, and Controlled Drug Release

Örüm, Simge Metinoğlu; Demircioğlu, Yasemin Süzen

doi:10.1007/s13233-018-6092-2

Cited by 23 publications

(15 citation statements)

References 34 publications

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“…The obtained average diameter for the QCT based nanoparticles was ranged from 345 nm to 434 nm. [39] The surface morphology of the nanospheres was depended on the reaction time and concentration of both monomer and cross-linker respectively. The reaction for the synthesis of QCT based nanoparticles is shown in Scheme 9.…”

Section: Preparation Of Cmppz Based Micro/nanospheres Containing Hydrmentioning

confidence: 99%

“…In QCT based nanospheres the band for the unreacted PÀ Cl bonds was appeared at 565 cm À 1 . [39] The thermal properties of the QCT based nanospheres were checked by TGA analysis. The TGA analysis showed two steps weight loss for QCT based nanospheres.…”

Section: Preparation Of Cmppz Based Micro/nanospheres Containing Hydrmentioning

confidence: 99%

“…SEM images of QCT based nanospheres (a) before and (b) after the release of acriflavine. [39] Reprinted with the permission from reference copyright 2018, Springer Nature. mers were kept 20 and 30 wt %.…”

Section: Various Factors Affecting the Properties Of Microspheresmentioning

confidence: 99%

“…The surface morphology of the nanospheres was depended on the reaction time and concentration of both monomer and cross-linker respectively. [39] The synthesized QCT based nanospheres were used for the drug released study. For this purpose acriflavine was used as a model drug, which has an anti-cancer and anti-microbial activity.…”

Section: Applications Of Cmppz Based Micro/nanospheres For Drug Deliverymentioning

confidence: 99%

“…The CMPPZ based micro/nanospheres could be synthesized under relative moderate conditions through a one-step precipitation polymerization reaction.. [30,31] Recently, large number of polymeric drug delivery systems such as hydrogels, [32] linear polymers, [33] micro and nanospheres [34][35][36] have been designed. Up to now HCCP has used successfully in the preparation of trimethoprim microspheres, [37] resveratrol microspheres, [38] quercetin nanospheres, [39] doxorubicin nanoparticles, [40] 4,5-dibromofluorescin (DBF) nanoparticles [41] and dichlorofluorescein (FD) nanoparticles. [42] The prepared micro/nanospheres were used successfully in drug delivery system for the biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

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Recent Progress on the Preparation of Cyclomatrix‐Polyphosphazene Based Micro/Nanospheres and Their Application for Drug Release

Mehmood

et al. 2020

ChemistrySelect

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Polyphosphazenes (PPZs) are the hybrid polymers composed of nitrogen and phosphorous atoms linked through alternate single and double bond. For the preparation of cyclomatrix polyphosphazene (CMPPZ) based micro/nanospheres, hexachlorocyclotriphosphazene (HCCP) was reacted with monomers containing hydroxyl and amino groups. The cross-linked structure of CMPPZ is biodegradable and biocompatible in nature. The CMPPZ based micro/nanospheres have potential application in the field of biomedical. In this review article, we have described the different ways for the preparation of CMPPZ based micro/nanospheres and their drug release behavior. The average diameter size and surface morphology of the highly cross-linked CMPPZ based micro/nanospheres depended on the concentration of both the monomers. This review article also emphasized on the drug release properties of the CMPPZ based micro/nanospheres.

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Section: Preparation Of Cmppz Based Micro/nanospheres Containing Hydrmentioning

confidence: 99%

Section: Preparation Of Cmppz Based Micro/nanospheres Containing Hydrmentioning

confidence: 99%

Section: Various Factors Affecting the Properties Of Microspheresmentioning

confidence: 99%

Section: Applications Of Cmppz Based Micro/nanospheres For Drug Deliverymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Recent Progress on the Preparation of Cyclomatrix‐Polyphosphazene Based Micro/Nanospheres and Their Application for Drug Release

Mehmood

et al. 2020

ChemistrySelect

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Effect of cyclophosphazene nucleated hyperbranched polyester on flame retardancy and mechanical properties of epoxy resins

Tian

Zhu

et al. 2022

J of Applied Polymer Sci

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Hexakis(4-hydroxyphenoxy) cyclotriphosphazene (PN-OH) was synthesized by a nucleophilic substitution and aldehyde reduction reaction of hexachlorocyclotriphosphazene with p-hydroxybenzaldehyde, and then cyclophosphazene nucleated hyperbranched polyesters (HBP) were prepared via a one-pot esterification reaction of PN-OH and dimethylolpropionic acid. The chemical structure and molecular weight distribution of HBP were confirmed by 1 H-NMR, FTIR, and GPC. The HBP was applied to epoxy resin (EP) to improve its mechanical properties and flame retardancy. The cone calorimeter test revealed that the maximum heat release rate, total heat release and total smoke release of HBP/EP composites were reduced by 35.9%, 21.6%, and 27.3%, respectively, when 7 wt% HBP was added to the EP matrix compared with pure EP. Meanwhile, when 7 wt% HBP was added to EP composites, the limiting oxygen index value was increased from 24.6% to 27.7% and the UL-94 test reached a V-1 rating. More importantly, the thermal stability and mechanical properties of the HBP/EP composites were enhanced. The flame retardant mechanism analysis showed that HBP primarily acted as a flame retardant in the condensed phase. These results indicate that the HBP/EP composites have exceptional overall performance and a broad range of applications in critical fields.

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One‐Pot Synthesis of Size‐Controlled Poly(cyclotriphosphazene‐co‐hesperetin) Microspheres and Their Properties as Drug Delivery Carriers

Mehmood

Uddin

et al. 2022

ChemistrySelect

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In this study, cross‐linked poly(cyclotriphosphazene‐co‐hesperetin) (PCTPHP) microspheres were synthesized by the reaction of hexachlorocyclotriphosphazene (HCCP) with hesperetin (HSP). Fourier transform infrared (FT‐IR) spectroscopy was used to confirm the successful preparation of the PCTPHP microspheres. The cross‐linking density of the prepared PCTPHP microspheres was examined by electron paramagnetic resonance (EPR) spectroscopy. The results showed that the increased HSP mole might be more suitable to cross‐link with HCCP in high density. The thermal properties, particle size distribution, morphology and crystalline nature of PCTPHP microspheres were investigated by thermogravimetric analysis (TGA), dynamic light scattering (DLS), scanning electron microscope (SEM) and X‐ray diffraction (XRD). The prepared PCTPHP‐3 microspheres were used as drug carriers. The 5‐fluorouracil (5‐FU) was loaded on the microspheres and their in vitro release behavior was observed at two different pH values. The results showed a controlled release of 5‐FU from the PCTPHP‐3/5‐FU in both basic and acidic mediums up to 216 h. The results showed that the PCTPHP microspheres might play a vital role as drug carriers in cancer therapy.

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Crosslinked Polyphosphazene Nanospheres with Anticancer Quercetin: Synthesis, Spectroscopic, Thermal Properties, and Controlled Drug Release

Cited by 23 publications

References 34 publications

Recent Progress on the Preparation of Cyclomatrix‐Polyphosphazene Based Micro/Nanospheres and Their Application for Drug Release

Recent Progress on the Preparation of Cyclomatrix‐Polyphosphazene Based Micro/Nanospheres and Their Application for Drug Release

Effect of cyclophosphazene nucleated hyperbranched polyester on flame retardancy and mechanical properties of epoxy resins

One‐Pot Synthesis of Size‐Controlled Poly(cyclotriphosphazene‐co‐hesperetin) Microspheres and Their Properties as Drug Delivery Carriers

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