Crosslinked nanocollagen-cellulose nanofibrils reinforced electrospun polyvinyl alcohol/methylcellulose/polyethylene glycol bionanocomposites: Study of material properties and sustained release of ketorolac tromethamine

Synthesis of nanohybrid reinforced electrospun methylcellulose/ polyvinyl alcohol /polyethylene glycol nanofiber: study of material properties for possible biomedical applications

“…Due to the unique features of nanofibers give an opportunity for using them potentially in the field of biomedical and healthcare applications [2]. The electrospinning technique is an easy, versatile and unique technique which has drawn significant attention to the production of nanofibrous structures with diameters less than one micrometer (𝜇M) from polymer solutions [3]. In recent decades, the synthesis of nanocellulose (NC) and its reinforced polymer composite materials have received tremendous devotion due to their remarkable mechanical, biological and physiochemical properties [3].…”

“…Cellulose nanocrystals (CNCs) (Fig. 1d) and nanocollagen (NCG) are biocompatible, biodegradable green nano-dimensional fillers with amazing drug loading and releasing properties, which make them a good candidate for utilization in the various biomedical platform [3,4]. Extensive research has been done on the extraction of CNCs and NCG from various bio-resources.…”

“…The chemical along with mechanical approaches are mainly adopted to isolate the CNCs and NCG nanofiller agents and their reinforced polymer nanocomposites. Nanocollagen and nanocellulose (NC) blended composites offer numerous advantages in biomedical applications e.g., carrier systems for protein, gene, and pharmaceutical drugs [3,[5][6][7]. CNCs is common cellulose based reinforcing agent with remarkable biological properties widely used in the health care sector [7] as well as a carrier agent widely used in biomedical nanotechnology applications [6].…”

“…Methylcellulose (MC) (structure shown in Fig. 1b) [3] and polyvinyl alcohol (PVA) (structure shown in Fig. 1 ai & aii) have various biomedical applications like wound healing and tissue engineering [3].…”

“…1b) [3] and polyvinyl alcohol (PVA) (structure shown in Fig. 1 ai & aii) have various biomedical applications like wound healing and tissue engineering [3]. Ketorolac tromethamine (KT) (structure shown in Fig.…”