Crosslinkable surfactants based on linoleic acid-functionalized block copolymers of ethylene oxide and ε-caprolactone for the preparation of stable PMMA latices

Tan, BoonHua; Grijpma, Dirk W.; Nabuurs, Tijs; Feijén, Jan

doi:10.1016/j.polymer.2004.11.070

Cited by 23 publications

(28 citation statements)

References 34 publications

(46 reference statements)

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“…First, although porous PMMA has been well studied, 24,27,[36][37][38][39] including porous PMMA fabricated using an aqueous phase consisting of a CMC hydrogel as a porogen, 25,40 the present study is one of the first systematic studies of fabrication methods to quantitatively examine the effect of both the ratio of aqueous phase to polymer phase but also the effect of the aqueous phase viscosity as done by varying the amount of CMC within the aqueous phase. Increasing the viscosity of the aqueous phase by using a 9 wt% CMC hydrogel, as opposed to a 7 wt% CMC gel as has been previously used, 41 resulted in a more consistent pore architecture with smaller, more consistently sized pore interconnections.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Soft Tissue Coverage over Porous Polymethylmethacrylate Space Maintainers Within Nonhealing Alveolar Bone Defects

Kretlow

Shi

Young

et al. 2010

Tissue Engineering Part C: Methods

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Current treatment of traumatic craniofacial injuries often involves early free tissue transfer, even if the recipient site is contaminated or lacks soft tissue coverage. There are no current tissue engineering strategies to definitively regenerate tissues in such an environment at an early time point. For a tissue engineering approach to be employed in the treatment of such injuries, a two-stage approach could potentially be used. The present study describes methods for fabrication, characterization, and processing of porous polymethylmethacrylate (PMMA) space maintainers for temporary retention of space in bony craniofacial defects. Carboxymethylcellulose hydrogels were used as a porogen. Implants with controlled porosity and pore interconnectivity were fabricated by varying the ratio of hydrogel:polymer and the amount of carboxymethylcellulose within the hydrogel. The in vivo tissue response to the implants was observed by implanting solid, low-porosity, and high-porosity implants (n = 6) within a nonhealing rabbit mandibular defect that included an oral mucosal defect to allow open communication between the oral cavity and the mandibular defect. Oral mucosal wound healing was observed after 12 weeks and was complete in 3/6 defects filled with solid PMMA implants and 5/6 defects filled with either a low- or high-porosity PMMA implant. The tissue response around and within the pores of the two formulations of porous implants tested in vivo was characterized, with the low-porosity implants surrounded by a minimal but well-formed fibrous capsule in contrast to the high-porosity implants, which were surrounded and invaded by almost exclusively inflammatory tissue. On the basis of these results, PMMA implants with limited porosity hold promise for temporary implantation and space maintenance within clean/contaminated bone defects.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Soft Tissue Coverage over Porous Polymethylmethacrylate Space Maintainers Within Nonhealing Alveolar Bone Defects

Kretlow

Shi

Young

et al. 2010

Tissue Engineering Part C: Methods

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“…Samples were excited at 370 nm (slit width 5 nm) and fluorescence spectra recorded in the range 400-600 nm (slit width 5 nm). Hydrophilic-lipophilic balance (HLB) of diblocks were calculated as follows [49]:…”

Section: Determination Of Cmc and Hlbmentioning

confidence: 99%

Interaction of bovine serum albumin with some novel PEG-containing diblock copolymers

Asadi

Saboury

Moosavi-Movahedi

et al. 2008

International Journal of Biological Macromolecules

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“…A synthetic block copolymer based on methyl poly(ethylene oxide) (mPEO) and ε ‐caprolactone (CL) and functionalized with linoleic acid (LA), developed as a surfactant in water‐based latex paints,39, 40 is characterized by means of LC/MS. The applicability of the selected gradient elution LC system is discussed, but the main focus is directed on the complementary character of ESI and APCI, in both the positive and the negative ion modes.…”

mentioning

confidence: 99%

A New Methodology for the Synthesis of Fluorinated exo‐Glycals and Their Time‐Dependent Inhibition of UDP‐Galactopyranose Mutase

Caravano

Dohi

Sînaÿ

et al. 2006

Chemistry A European J

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Fluorinated carbohydrates constitute a very important class of mechanistic probes for glycosyl-processing enzymes. In this study, we describe the first synthesis of fluorinated and phosphonylated exo-glycals and their corresponding nucleotide sugars in the galactofuranose series. The synthetic protocol that we have developed is a Selectfluor-mediated fluorination/elimination sequence on phosphonylated exo-glycals, and it offers a new entry into fluorinated carbohydrate chemistry. The challenging E/Z stereochemical assignment of the resulting tetrasubstituted alkenes, which bear an alkoxy, an alkyl, a fluoro, and a phosphonyl group, has been achieved through NMR experiments. The corresponding (E)- and (Z)-nucleotide fluorosugars have been prepared and tested as inhibitors of UDP-galactopyranose mutase (UGM). UGM is a flavoenzyme that catalyzes the isomerization of uridine diphosphate(UDP)-galactopyranose into UDP-galactofuranose, a key step of the biosynthesis of important mycobacterial cell-wall glycoconjugates. The two diastereomeric molecules were found to display time-dependent inactivation of UGM, as expected from preliminary results using non-fluorinated exo-glycal nucleotides. The inhibitory properties of the two fluorinated molecules led us to suggest that the inactivation mechanism proceeds through two-electron processes, despite the presence of the flavin cofactor within the UGM catalytic site.

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Crosslinkable surfactants based on linoleic acid-functionalized block copolymers of ethylene oxide and ε-caprolactone for the preparation of stable PMMA latices

Cited by 23 publications

References 34 publications

Evaluation of Soft Tissue Coverage over Porous Polymethylmethacrylate Space Maintainers Within Nonhealing Alveolar Bone Defects

Evaluation of Soft Tissue Coverage over Porous Polymethylmethacrylate Space Maintainers Within Nonhealing Alveolar Bone Defects

Interaction of bovine serum albumin with some novel PEG-containing diblock copolymers

A New Methodology for the Synthesis of Fluorinated exo‐Glycals and Their Time‐Dependent Inhibition of UDP‐Galactopyranose Mutase

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