Cross-Talk Between Gut Microbiota and Adipose Tissues in Obesity and Related Metabolic Diseases

Wu, Dan; Wang, Huiying; Xie, Ling; Hu, Fang

doi:10.3389/fendo.2022.908868

Cited by 22 publications

(20 citation statements)

References 162 publications

(270 reference statements)

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“…To date, several mechanisms have been proposed to explain the potential role of the gut microbiota in the development of obesity. Some evidence suggests that the gut microbiota contributes to metabolism and metabolic disorders through a close cross-talk with host adipose tissue [ 54 , 55 ].…”

Section: Obesity and Gut Microbiotamentioning

confidence: 99%

Beneficial Effects of Anti-Inflammatory Diet in Modulating Gut Microbiota and Controlling Obesity

2022

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Obesity has consistently been associated with an increased risk of metabolic abnormalities such as diabetes, hyperlipidemia, and cardiovascular diseases, as well as the development of several types of cancer. In recent decades, unfortunately, the rate of overweight/obesity has increased significantly among adults and children. A growing body of evidence shows that there is a relationship between metabolic disorders such as obesity and the composition of the gut microbiota. Additionally, inflammation is considered to be a driving force in the obesity–gut microbiota connection. Therefore, it seems that anti-inflammatory nutrients, foods, and/or diets can play an essential role in the management of obesity by affecting the intestinal flora and controlling inflammatory responses. In this review, we describe the links between the gut microbiota, obesity, and inflammation, and summarize the benefits of anti-inflammatory diets in preventing obesity.

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Section: Obesity and Gut Microbiotamentioning

confidence: 99%

Beneficial Effects of Anti-Inflammatory Diet in Modulating Gut Microbiota and Controlling Obesity

2022

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“…10 22-24 There seems to be a crosstalk between the host metabolism, microbiome and adipose tissue, which seems particularly important during pregnancy. [24][25][26] The vaginal microbiome Lactobacillus species (spp) are the most common colonisers of the vaginal tract in women of reproductive age. 8 27 28 Some women lack this Lactobacillus dominance in the vagina and have a diverse composition of other bacteria, including anaerobic bacteria, referred to as vaginal dysbiosis, which is asymptomatic in up to 50%.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

“…Obesity, excessive weight gain and gestational diabetes all leave an apparently distinct signature on the microbiome 10 22–24. There seems to be a crosstalk between the host metabolism, microbiome and adipose tissue, which seems particularly important during pregnancy 24–26…”

Section: Introductionmentioning

confidence: 99%

Cohort profile: the Swedish Maternal Microbiome project (SweMaMi) – assessing the dynamic associations between the microbiome and maternal and neonatal adverse events

et al. 2022

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PurposeThe Swedish Maternal Microbiome (SweMaMi) project was initiated to better understand the dynamics of the microbiome in pregnancy, with longitudinal microbiome sampling, shotgun metagenomics, extensive questionnaires and health registry linkage.ParticipantsPregnant women were recruited before the 20th gestational week during 2017–2021 in Sweden. In total, 5439 pregnancies (5193 unique women) were included. For 3973 pregnancies (73%), samples were provided at baseline, and for 3141 (58%) at all three timepoints (second and third trimester and postpartum). In total, 38 591 maternal microbiome samples (vaginal, faecal and saliva) and 3109 infant faecal samples were collected. Questionnaires were used to collect information on general, reproductive and mental health, diet and lifestyle, complemented by linkage to the nationwide health registries, also used to follow up the health of the offspring (up to age 10).Findings to dateThe cohort is fairly representative for the total Swedish pregnant population (data from 2019), with 41% first-time mothers. Women with university level education, born in Sweden, with normal body mass index, not using tobacco-products and aged 30–34 years were slightly over-represented.Future plansThe sample and data collection were finalised in November 2021. The next steps are the characterisation of the microbial DNA and linkage to the health and demographic information from the questionnaires and registries. The role of the microbiome on maternal and neonatal outcomes and early-childhood diseases will be explored (including preterm birth, miscarriage) and the role and interaction of other risk factors and confounders (including endometriosis, polycystic ovarian syndrome, diet, drug use). This is currently among the largest pregnancy cohorts in the world with longitudinal design and detailed and standardised microbiome sampling enabling follow-up of both mothers and children. The findings are expected to contribute greatly to the field of reproductive health focusing on pregnancy and neonatal outcomes.

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“…“We are what we eat” is true in more than one sense: what we eat will either help maintain a healthy gut microbiota or cause disease by creating ground for the overgrowth of pathogens. As indicated by the high number of reviews in PubMed (787), there is a very large body of experimental evidence linking abnormal gut microbiota (so-called “dysbacteriosis”) to metabolic syndrome [ 116 , 117 , 118 , 119 ]. The gut-centric theory of metabolic syndrome posits that an unhealthy diet (for example a diet rich in fat and poor in fibers) permits the growth of pathogens in the colon, leading to metabolic endotoxemia and impaired insulin sensitivity [ 116 ].…”

Section: Capsaicin Gut Microbiota and Metabolic Syndromementioning

confidence: 99%

Dietary Capsaicin: A Spicy Way to Improve Cardio-Metabolic Health?

Szállaśi

2022

Biomolecules

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Today’s sedentary lifestyle with too much food and too little exercise has made metabolic syndrome a pandemic. Metabolic syndrome is a major risk factor for type-2 diabetes and cardiovascular disease. New knowledge of medical and nutraceutical intervention in the early stages of metabolic syndrome is central to prevent these deadly complications. People who eat chili pepper on a regular basis seem to stay healthier and live longer than those who do not. Animal experiments suggest a therapeutic potential for dietary capsaicin, the active principle in hot chili pepper, to reduce the risk of developing metabolic syndrome. This is an attractive theory since capsaicin has been a culinary staple for thousands of years, and is generally deemed safe when consumed in hedonically acceptable doses. The broad expression of the capsaicin receptor TRPV1 in metabolically active tissues lends experimental support to this theory. This review critically evaluates the available experimental and clinical evidence for and against dietary capsaicin being an effective dietary means to improve cardio-metabolic health. It comes to the conclusion that although a chili pepper-rich diet is associated with a reduced risk of dying due to cardiovascular disease, dietary capsaicin has no clear effect on blood glucose or lipid profiles. Therefore, the reduced mortality risk may reflect the beneficial action of digested capsaicin on gut microbiota.

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Cross-Talk Between Gut Microbiota and Adipose Tissues in Obesity and Related Metabolic Diseases

Cited by 22 publications

References 162 publications

Beneficial Effects of Anti-Inflammatory Diet in Modulating Gut Microbiota and Controlling Obesity

Beneficial Effects of Anti-Inflammatory Diet in Modulating Gut Microbiota and Controlling Obesity

Cohort profile: the Swedish Maternal Microbiome project (SweMaMi) – assessing the dynamic associations between the microbiome and maternal and neonatal adverse events

Dietary Capsaicin: A Spicy Way to Improve Cardio-Metabolic Health?

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