Dietary Capsaicin: A Spicy Way to Improve Cardio-Metabolic Health?

Abstract

Today’s sedentary lifestyle with too much food and too little exercise has made metabolic syndrome a pandemic. Metabolic syndrome is a major risk factor for type-2 diabetes and cardiovascular disease. New knowledge of medical and nutraceutical intervention in the early stages of metabolic syndrome is central to prevent these deadly complications. People who eat chili pepper on a regular basis seem to stay healthier and live longer than those who do not. Animal experiments suggest a therapeutic potential for dietary capsaicin, the active principle in hot chili pepper, to reduce the risk of developing metabolic syndrome. This is an attractive theory since capsaicin has been a culinary staple for thousands of years, and is generally deemed safe when consumed in hedonically acceptable doses. The broad expression of the capsaicin receptor TRPV1 in metabolically active tissues lends experimental support to this theory. This review critically evaluates the available experimental and clinical evidence for and against dietary capsaicin being an effective dietary means to improve cardio-metabolic health. It comes to the conclusion that although a chili pepper-rich diet is associated with a reduced risk of dying due to cardiovascular disease, dietary capsaicin has no clear effect on blood glucose or lipid profiles. Therefore, the reduced mortality risk may reflect the beneficial action of digested capsaicin on gut microbiota.

The effects of systemic diseases, genetic disorders and lifestyle on keloids

“…The mechanism of capsaicin can briefly be described as capsaicin enhances endothelium-dependent vasodilation through perivascular sensory neurons. 88 Smoking is generally believed to impair wound healing, causing higher postoperative wound infection and other perioperative complications. 89 These mechanisms involve impairing the phagocytic and bactericidal activity of inflammatory cells, inhibiting fibroblast migration and reducing collagen deposition.…”

“…The mechanism of capsaicin can briefly be described as capsaicin enhances endothelium‐dependent vasodilation through perivascular sensory neurons. 88 …”

Korelasi antara Sarapan Pagi dengan Sindrom Dispepsia dan Aktivitas Fisik pada Anak Usia 10-12 tahun di Surakarta

“…Keterkaitan antara aktivitas fisik dan makanan pedas menunjukkan hubungan yang sangat lemah dan tidak signifikan, sejalan dengan temuan penelitian sebelumnya (Amelia N, Ayu D, 2023). Pengaruh konsumsi makanan pedas terhadap aktivitas fisik tidak signifikan, karena reaksi terhadap makanan pedas bersifat subjektif dan dapat bervariasi antara individu Dimana beberapa orang merasa lebih sensitif terhadap efek panasnya, sementara yang lain merasa nyaman mengonsumsi makanan pedas tanpa masalah (Szallasi, 2022).…”

The Vanilloid (Capsaicin) Receptor TRPV1 in Blood Pressure Regulation: A Novel Therapeutic Target in Hypertension?

“…Large epidemiological studies imply health benefits for chili lovers, including lower risk for obesity and cardiovascular disease [6][7][8][9]. Despite intensive research, the molecular mechanisms by which capsaicin may exert these health benefits are yet to be determined [10,11].…”