Cross-sectionl Study on Relationship between Constipation and Medication

Ueki, Tetsuya; Tasaki, Naoko; Yoshida, Tetsuo; Ooe, Nobuharu; Nishida, Koyo; Nakamura, Junzo; Nakashima, Makoto

doi:10.5649/jjphcs.34.865

Cited by 2 publications

(4 citation statements)

References 22 publications

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“…Our previous studies on the relationship between constipation and drugs showed that hypnotics were signiˆcantly related to constipation; 12,13) however, sleep conditions were not taken into consideration. The aim of the present study was to determine whether there is a relationship between hypnotics and constipation, with considering potential confounding factors such as sleep disorders.…”

Section: Discussionmentioning

confidence: 99%

“…They also studied this relation by actigraphy measurement and fecal ‰ora analysis; 17) however, those studies did not consider the in‰uence of drug use. On the other hand, hypnotics were strongly related to constipation in our recent studies, 12,13) but it was not clear whether this was due to the clinical condition of sleep disorder or adverse eŠects of the hypnotics.…”

Section: Introductionmentioning

confidence: 99%

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Cross-sectional Study on Relationship between Constipation and Medication in Consideration of Sleep Disorder

et al. 2011

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Constipation can be caused by adverse drug reactions as a result of many drugs and might be induced by sleep disorders; however, the relative risk of its occurrence with individual drugs and the in‰uence of sleep conditions have not been clariˆed. To clarify the relationship between constipation and various drugs in consideration of sleep disorders, we investigated the self-reported bowel habits, use of laxatives, and the Athens Insomnia Scale (AIS, a self-administered psychometric instrument to measure insomnia) in 344 inpatients on admission. They were divided into a constipation group (self-reported bowel habits of``Constipation'' or``Occasional constipation'' and/or use of laxatives, n＝161) and a non-constipation group (both``Normal'' and the non-use of laxatives, n＝183). A comparison of the backgrounds of the two patient groups revealed signiˆcant diŠerences in age, gender, number of used drugs, AIS score, hypothyroidism, chronic obstructive pulmonary disease, use of diuretics, coronary vasodilators, thyroid hormones, non-steroidal anti-in‰ammatory drugs, proton pump inhibitors, antidepressants, anti-anxiety drugs, and hypnotics. Multiple logistic regression analysis using these fourteen factors as autonomous variables showed that age (odds ratio [OR], 1.03; 95％ conˆdence interval [CI], 1.01 1.04; p＝0.007), female gender (OR, 1.96; 95％ CI, 1.21 3.18; p＝ 0.006), the AIS score (OR, 1.10; 95％ CI, 1.02 1.18; p＝0.010), and the use of hypnotics (OR, 2.33; 95％ CI, 1.30 4.16; p＝0.004) were signiˆcantly related to constipation; therefore, as hypnotics appear more likely to cause constipation than other drugs, they should be used with caution.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cross-sectional Study on Relationship between Constipation and Medication in Consideration of Sleep Disorder

et al. 2011

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“…This view is also supported by our previous cross-sectional study. 17) Therefore, the administration of hypnotics may be undesirable for patients who should avoid development of constipation such as ileus patients. Care should be taken to prevent hypnotics-induced consti-pation.…”

Section: Elapsed Time For the Administration Of Laxatives In Case Gmentioning

confidence: 99%

“…13,14) A few previous reports have shown that constipating drugs are antidepressants, calcium channel blockers, iron preparations, opioids, diuretics, antihistamines, antispasmodics, anticonvulsants, and aluminum antacids. 15,16) In addition, hypnotics were strongly related to constipation in our recent cross-sectional study; 17) however, the degree of in‰uence of the various factors for the development of constipation is uncertain. Moreover, little is known about the relative risks among individual drugs in the hospital setting.…”

Section: Introductionmentioning

confidence: 99%

Case-controlled Study on Risk Factors for the Development of Constipation in Hospitalized Patients

et al. 2011

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Constipation is a common problem in hospitalized patients; however, the relative risks of its development with various factors have not been clariˆed. To clarify the risk factors associated with constipation, we performed a case-controlled study of 165 hospitalized patients who were not laxative users on admission. They were divided into case (n＝35) and control (n＝130) groups according to laxative administration during hospitalization. Comparison of the patient backgrounds in the two groups revealed signiˆcant diŠerences in the activities of daily living, length of fasting, rest level on admission, cerebrovascular disease, and administration of hypnotics. Multiple logistic regression analysis using thesê ve factors as autonomous variables showed that administration of hypnotics (odds ratio, 2.79; 95％ conˆdence interval, 1.10 7.06; p＝0.031) was signiˆcantly related to laxative use. Therefore, the administration of hypnotics may be the principal cause of constipation development in hospitalized patients and they should be used with caution.

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Cross-sectionl Study on Relationship between Constipation and Medication

Cited by 2 publications

References 22 publications

Cross-sectional Study on Relationship between Constipation and Medication in Consideration of Sleep Disorder

Cross-sectional Study on Relationship between Constipation and Medication in Consideration of Sleep Disorder

Case-controlled Study on Risk Factors for the Development of Constipation in Hospitalized Patients

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