Cross-sectional Study on Relationship between Constipation and Medication in Consideration of Sleep Disorder

Ueki, Tetsuya; Nagai, Keinosuke; Mizukami, Yasuko; Takahashi, Akihiro; Ooe, Nobuharu; Nakashima, Mihoko N.; Nishida, Koyo; Nakamura, Junzo; Nakashima, Makoto

doi:10.1248/yakushi.131.1225

Cited by 12 publications

(20 citation statements)

References 26 publications

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“…Age was found to be an important predictor of constipation in the general population. (11,12,16,(20)(21)(22)26) However, while previous studies (3,7) and the present study did not find age to be associated with poststroke constipation, the present study did find that younger patients with stroke tended to have transient, instead of chronic, constipation.…”

Section: Resultscontrasting

confidence: 87%

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Poststroke constipation in the rehabilitation ward: incidence, clinical course and associated factors

Lin

Hung²,

Cho³

et al. 2013

smedj

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Bowel management is important in poststroke rehabilitation as constipation is the dominant gastrointestinal problem after stroke. (1-3) The prevalence of constipation in patients with stroke has been reported to range from 22.9% to 60%, (1-4) and the unpleasant symptoms of constipation are often distressing to both patients and their caregivers. It has a negative effect on the patients' quality of life and may limit social activities. (5,6) A proactive approach toward treating constipation in patients with stroke is thus warranted, but few studies have focused on this topic. Furthermore, as the definitions of constipation and study designs varied in the few studies that focused on constipation in poststroke patients, it is difficult to compare their results. (3,4,7) The diagnosis of constipation is also more complex in patients with stroke than in the general population. Patients with stroke may have poor verbal expression or cognition, which may result in undiagnosed or misdiagnosed constipation. To the best of our knowledge, there are no reports in the literature that specifically address the bowel function of patients who have difficulty expressing themselves. In addition, most studies on poststroke constipation were cross-sectional, and did not report information about the clinical course of constipation and the relevant interventions. (4,7) Since multiple factors can contribute to poststroke constipation, identifying these factors will be useful for early diagnosis and treatment. The classification of the severity of poststroke constipation, while not done in any previous study, would also be useful in the management of this condition. Unfortunately, while efforts have been made to identify the risk factors for poststroke constipation, (3,4,7) none have been found for severe constipation. Thus, the aims of this study were to (a) document the incidence of poststroke constipation among patients in a rehabilitation ward, (b) examine the clinical course of poststroke constipation, and (c) identify the factors that are independently associated with general or severe poststroke constipation. M E TH O DS We retrospectively reviewed the charts of all patients who had had an acute stroke and were admitted to the rehabilitation ward of a tertiary hospital over a 12-month period. The study was approved by the Ethics Research Committee of the hospital. Stroke diagnosis and localisation were confirmed using computed tomography or magnetic resonance imaging. Patients with a prior history of constipation before the stroke diagnosis and patients with subarachnoid haemorrhage

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Section: Resultscontrasting

confidence: 87%

“…analgesics, antidepressants, benzodiazepines, antihistamines and diuretics) at admission. (15,16) Medical complications that occurred during inpatient rehabilitation were recorded. Pneumonia, urinary tract infection, upper gastrointestinal bleeding and recurrent stroke were considered major complications.…”

Section: Introductionmentioning

confidence: 99%

Poststroke constipation in the rehabilitation ward: incidence, clinical course and associated factors

Lin

Hung²,

Cho³

et al. 2013

smedj

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“…The severity of acne vulgaris was evaluated using the Global Acne Grading System (GAGS) [28]. The sleep quality of patients were assessed using Athens Insomnia Scale (AIS), which is a self-administered psychometric instrument [29]. Dermatology Life Quality Index (DLQI) was applied to assess patients’ quality of life [30].…”

Section: Methodsmentioning

confidence: 99%

Association of brain-derived neurotrophic factor levels and depressive symptoms in young adults with acne vulgaris

Tian

Deng

et al. 2019

BMC Psychiatry

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Background: Brain-derived neurotrophic factor (BDNF) is one of the proteins that contributes to the survival, growth, maintenance of neurons, and plays important roles in the pathophysiology of depression. It has been reported that depression is closely associated with the pathogenesis of acne vulgaris disease. But, there is no report of serum BDNF levels in patients with acne vulgaris. The study aimed to determine the potential association between BDNF and depressive symptoms in young adults with acne vulgaris. Methods: In this analytical cross-sectional study, the serum BDNF levels were measured in peripheral blood samples of 20 consecutive acne vulgaris patients with depression and 98 consecutive acne vulgaris patients without depression and also compared it with a 59 healthy control group by using a ELISA. The potential correlation between the BDNF levels, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), and depressive symptoms such as nine-item patient health questionnaire (PHQ-9) and Athens insomnia scale (AIS) were evaluated with multivariate logistic regression analysis. Results: Our results showed that levels of BDNF expression were lower in consecutive acne vulgaris patients when compared with healthy control (P < 0.05). There was a negative correlation between levels of BDNF and the PHQ-9 scores (r = − 0.486, P < 0.001). Furthermore, acne vulgaris patients with depression showed lower serum BDNF levels (10.96 ± 2.12 ng/ml) compared with acne vulgaris patients without depression (13.85 ± 2.47 ng/ml), as well as with healthy control (14.35 ± 2.70 ng/mg; both P < 0.05). No difference was found in serum BDNF levels between healthy control and acne vulgaris patients without depressive symptoms (z = 0.964, P > 0.05). Similarly, the overall area under the curve of receiver operating characteristic was 0.82, indicating the highly conserving of serum BDNF levels as an biomarker for screening of depression in young adults with acne vulgaris (72% sensitivity and 85% specificity). Conclusion: Serum BDNF levels were decreased and negatively associated with depressive symptoms in young Chinese adults with acne vulgaris.

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“…Con respecto a las diferencias significativas halladas en el consumo de ciertos nutrientes según edad, debe considerarse que a partir de la tercera edad se producen cambios importantes a nivel fisiológico: se reducen las secreciones enzimáticas, con consecuencias sobre la absorción de ciertas vitaminas y oligoelementos (19), deterioro del estado bucal, pérdida de piezas dentarias (20), salivación disminuida (21), problemas de deglución (22), que hacen que el proceso de masticación sea dificultoso y doloroso (23), y que predispone a la selección de alimentos de consistencia blanda y suave (24). Debe considerarse que la presencia de patologías es muy frecuente (enfermedades cardiovasculares, diabetes, enfermedad de Parkinson, accidente cerebrovascular, demencia), y por lo tanto, es también frecuente el uso de fármacos (opioides, antidepresivos, antiinflamatorios no esteroideos, hipnóticos), que intervienen no sólo en el apetito, sino también en el metabolismo de los nutrientes y en la fisiología digestiva (25). La coexistencia de estos cambios junto con la utilización de fármacos incide de manera significativa sobre el estado nutricional de los AM.…”

Section: Tablaunclassified

Caracterización De La Ingesta De Alimentos Y Nutrientes en Adultos Mayores Chilenos

D'ardaillon

2016

Rev. chil. nutr.

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Introduction: The elderly population is a constantly growing demographic group in Chile and worldwide. It represents a group of high nutritional risk, given the health complications that occur. Objective: To describe the quantity and quality of nutrients, and the main food consumed by elderly, older and younger than 80 years. Subjects and methods: 514 autonomous elderly men and women, living in Santiago, Chile participated in the study. Food intake was assessed using a food frequency questionnaire. About 338 foods were collected, and the contribution of macro and micronutrients by food groupwas calculated. Comparisons were made on the average intake between older and younger than 80 years. Results: No significant differences in macro and micronutrient intake among women, older and younger than 80 years were found. Differences in the intake by age in the men group was found, for calories, carbohydrates, fiber, iron, thiamin, niacin, folate, pantothenic acid, copper, magnesium, and selenium (p<0.05). Bread is an important contributor of folic acid and B vitamins. Dairy contributed the greatest amount of B12. Most iron was provided by bread and cereals. Calcium provided by dairy and breads. Conclusions: The traditional foods in the Chilean diet, such asbread, contribute significantly to the intake of nutrients. It would be important to thoroughly analyze the reasons why differencesin consumption where found in men, older and younger than 80 years, to improve nutrient intake in this population at risk.

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Cross-sectional Study on Relationship between Constipation and Medication in Consideration of Sleep Disorder

Cited by 12 publications

References 26 publications

Poststroke constipation in the rehabilitation ward: incidence, clinical course and associated factors

Poststroke constipation in the rehabilitation ward: incidence, clinical course and associated factors

Association of brain-derived neurotrophic factor levels and depressive symptoms in young adults with acne vulgaris

Caracterización De La Ingesta De Alimentos Y Nutrientes en Adultos Mayores Chilenos

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