Cross Sectional Imaging of Post Partum Headache and Seizures

Hiremath, Ravishekar N; Mundaganur, Praveen M.; Sonwalkar, Pradeep

doi:10.7860/jcdr/2014/8783.5234

Cited by 8 publications

(13 citation statements)

References 10 publications

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“…In another study conducted by Bartynki, et al [12], parieto-occipital lobe was involved most commonly (98%) followed by frontal lobe (68%) and cerebellar hemispheres (32%). The regions involved in our present study was comparable to the study conducted by Hiremath, et al [6] where following parieto-occipital lobe involvement, frontal and cerebellar regions were noticed ( Table 7). Table 7: Comparison of the regions in brain involved in Posterior reversible encephalopathy syndrome by Hiremath, et al [6] and our present study.…”

Section: Discussionsupporting

confidence: 91%

“…In our study predominantly parietooccipital lobe involvement was seen. The regions involved were similar to the study by Hiremath, et al [6].…”

Section: Discussionsupporting

confidence: 83%

“…In our study majority (44% of patients with CVT) of patients presented with only venous thrombosis without brain parenchymal changes (Figure 4). In study by Hiremath, et al [6] out of 17 patients with cerebral venous thrombosis only three patients showed no parenchymal changes. 32% of the patients with CVT in our study had haemorrhagic infarct ( Figure 5) and 24% with ischemic infarct ( Figure 6).…”

Section: Discussionmentioning

confidence: 90%

“…The findings were similar to the study conducted by Magudeeswaran, et al [5] Table 6. In a study conducted by Hiremath, et al [6], CVT was the most common neurological entity encountered Table 6 Table 6: Comparison of the spectrum of acute neurological disorders in pregnancy and puerperium.…”

Section: Discussionmentioning

confidence: 99%

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Acute Neurological Disorders in Women during Pregnancy and Peurperium- A Cross Sectional Study

Chandan¹

2018

CRIJ

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Objective: To describe various imaging feature of acute neurological complications during pregnancy and puerperium, thereby sensitising the treating physician to necessitate appropriate treatment. Method: A cross sectional prospective study (MRI Brain) was done on 105 women suspected of acute neurological disorders during pregnancy and puerperium during the period January 2017-January 2018 in the department of Radiodiagnosis, in SSIMS & RC, Davangere and the results were analyzed. Results :Posterior Reversible Encephalopathy Syndrome was the most common neurological disorders in our study, accounting for 36% of acute neurological disorder followed by cerebrovascular thrombosis (CVT) (accounting for 22.8%), cerebrovascular accident (CVA) (8.2%), SAH (6.6%), meningitis (4.7%), Wernicke's encephalopathy (1.9%) and pituitary disorders (1.9%). 19 patients (17.7%) of the total had normal features on imaging. We also characterised 3 imaging patterns of posterior reversible encephalopathy syndrome, which was the most common neurological disorder. Typical feature consisting of bilateral symmetrical T2 and FLAIR hyperintensities with no diffusion restriction on MRI. Bilateral symmetrical T2 and FLAIR hyperintensity with subtle diffusion restriction on MRI. Bilateral symmetrical T2 and FLAIR hyperintensity with foci of hemorrhage. Conclusion: The incidence of acute neurological complication in pregnancy and puerperium is fairly high. PRES (36.1%) and CVT (22.8%) were the most common entities noticed. The most common presenting symptom is headache followed by seizures. Women in their puerperal period (from day 5-day 10) were more vulnerable for acute neurological complications according to our study. Hence timely imaging and familiarising spectrum of radiological features in women during pregnancy and puerperium is needed for initiating early therapy and preventing complications for both the mother and the fetus.

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Section: Discussionsupporting

confidence: 91%

“…In our study predominantly parietooccipital lobe involvement was seen. The regions involved were similar to the study by Hiremath, et al [6].…”

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Acute Neurological Disorders in Women during Pregnancy and Peurperium- A Cross Sectional Study

Chandan¹

2018

CRIJ

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“…Plk2, Plk3, and Plk5. Plks 2, 3, and 5 have been described as immediate early response genes since the expression of these three kinases increases upon DNA damage and oxidative stress [30][31][32][33][34][35]. This, in turn, leads to the activation of the G2/M checkpoint in a p53-dependent manner [36][37][38][39][40].…”

Section: The Plk Family: Expression Localization and Cellular Functmentioning

confidence: 97%

Polo-Like Kinases in Colorectal Cancer: Potential for Targeted Therapy

Kazazian

Brashavitskaya

Zih

et al. 2015

Curr Colorectal Cancer Rep

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The five individual members of the mammalian polo-like kinase family play non-redundant roles in centriole replication and maturation, mitotic progression, cytokinesis, and the DNA damage response. In human colorectal cancer, Plk1 and Plk4 are expressed at higher levels in tumor than adjacent normal mucosa, and the degree of overexpression correlates with adverse prognosis. In colorectal cancer cell lines, suppression of Plk1 activity leads to mitotic arrest and apoptosis, while inhibition of Plk4 activity reduces tumor growth and invasion. Inhibition of Plk1 or Plk4 in mice using orally bioavailable agents reduces the growth of human colorectal cancer xenografts. On the basis of these preclinical studies, clinical trials of several different targeted anti-Plk1 agents have been undertaken in patients with advanced solid tumors, and a phase I trial of the anti-Plk4 inhibitor CFI-400945 is currently accruing. Here, we review the rationale, results, and potential limitations of Plks as therapeutic targets. Evidence from genetic mouse models suggests that Plk1, Plk2, Plk3, and Plk4 may all possess tumor suppressive activity, particularly with aging. Thus, enthusiasm for the use of targeted Plk inhibitors in cancer therapy must be tempered somewhat by the potential for development of second primary tumors in the long term.

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Imaging neurological emergencies in pregnancy and puerperium

Haber

Nuñez

2018

Emerg Radiol

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The altered physiologic state of female patients during and just after pregnancy places them at an increased risk for several potentially life-threatening neurologic disorders. Swift diagnosis of such pathology and related complications is critical in order to reduce risk of morbidity and mortality to both the mother and the fetus. Neuroimaging plays an important role in the emergent diagnosis of pathology associated with pregnancy and puerperium, and it is critical for the radiologist to be cognizant of correlative imaging findings. Furthermore, given concerns regarding risks of neuroimaging to the fetus, it is important for the radiologist to act as an informed consultant regarding balancing fetal risks and the mother's health. The purpose of this review is to elucidate the underlying pathophysiology and neuroimaging findings associated with diagnoses that are unique to or highly associated with pregnancy and puerperium, as well as to understand the role that CT and MR play in diagnosis during and just after pregnancy, and their respective risks to the fetus.

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Cross Sectional Imaging of Post Partum Headache and Seizures

Cited by 8 publications

References 10 publications

Acute Neurological Disorders in Women during Pregnancy and Peurperium- A Cross Sectional Study

Acute Neurological Disorders in Women during Pregnancy and Peurperium- A Cross Sectional Study

Polo-Like Kinases in Colorectal Cancer: Potential for Targeted Therapy

Imaging neurological emergencies in pregnancy and puerperium

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