Cross-sectional comparison of synovial fluid biochemical markers in equine osteoarthritis and the correlation of these markers with articular cartilage damage

Fuller, Cathy J; Barr, A. R.; Sharif, Mohammed; Dieppe, P.

doi:10.1053/joca.2000.0349

Cited by 72 publications

(55 citation statements)

References 24 publications

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“…These results are in agreement with some authors [29,[43][44][45][46][47]. On the other hand, Belcher et al [33] and Fragonas et al [48] could not detect any significant correlation between the markers in synovial fluid and radiological findings.…”

Section: Discussionsupporting

confidence: 92%

“…Elevated levels of aggrecan epitopes and COMP in OA patients probably reflect an increased synthesis of aggrecan in degenerated cartilage or increased degradation with a resultant loss from the cartilage [18,[21][22][23][24][25][26][27][28]. However, Fuller et al [29] studied the level of aggrecan epitopes in OA synovial fluid and compared the results with that of the contralateral joint. They found no significant difference between the two sides, which could be explained by the fact that the contralateral joint is not necessarily normal to be used as a control.…”

Section: Discussionmentioning

confidence: 99%

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Aggrecan and Cartilage Oligomeric Matrix Protein in Serum and Synovial Fluid of Patients with Knee Osteoarthritis

et al. 2010

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Aggrecan and cartilage oligomeric matrix protein (COMP) which are important degradation products of articular cartilage may be promising diagnostic markers in serum and/or synovial fluid for diagnosis of knee osteoarthritis (OA). Our objective was to measure serum and synovial fluid levels of aggrecan and COMP in patients with OA of the knee joint to find out if they could be of diagnostic value in OA and if their levels correlate with the clinical and radiological manifestations of the disease. Sixty-six patients suffering from primary knee OA with effusion (26 males and 40 females) were studied. Twenty individuals (six males and 14 females) with recent traumatic knee effusion matched for age and sex were chosen to serve as a control group. All subjects had thorough clinical and radiological (X-ray and MRI) evaluation. Aggrecan and COMP in serum and synovial fluid were measured by ELISA. Serum and synovial fluid aggrecan and COMP levels were significantly higher than the control. Serum and synovial fluid aggrecan and COMP levels were positively correlated with age, body mass index, disease duration, plain X-ray and MRI scores. In OA, serum and synovial fluid aggrecan and COMP levels are elevated and represent useful markers in the diagnosis. Moreover, these elevated levels positively correlated with radiological joint damage but not with clinical disease parameters. These markers have the potential to be used for monitoring articular cartilage destruction and response to different therapeutic modalities.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Aggrecan and Cartilage Oligomeric Matrix Protein in Serum and Synovial Fluid of Patients with Knee Osteoarthritis

et al. 2010

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“…Later, the same authors cast doubts on GAG measurement in early stages of cartilage damage when no obvious changes could be seen since those values were lower compared to values of horses with at least minimal visible OA changes (van den Boom et al 2005). Negative correlations between GAG values in SF and cartilage damage stage were reported by other authors in horses, too (Fuller et al 2001). The GAG concentration and severity of radiographic changes correlated negatively even in dogs (Innes et al 1998) and there was no correlation between radiographic changes and GAG in human patients (Belcher et al 1997).…”

Section: Discussionmentioning

confidence: 82%

Measurement of glycosaminoglycans in canine synovial fluid and its correlation with the cause of secondary osteoarthritis, age and body weight

et al. 2012

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Glycosaminoglycans are natural components of healthy joint cartilage and they also appear in healthy synovial fluid. An increased amount of glycosaminoglycans in synovial fluid is believed to be a marker of secondary osteoarthritis, regardless of its primary cause. The aim of our study was to define the relationship between glycosaminoglycans in the synovial fluid and joint disorders, age, and body weight. The samples of synovial fluid were obtained from dogs suffering from secondary secondary osteoarthritis (n = 35) and from control dogs (n = 18); control dogs had normal body weight. The results were compared among joints of dogs with secondary osteoarthritis divided into groups according to the criteria mentioned above and control dogs. Glycosaminoglycan concentrations in synovial fluid were measured using dimethylmethylene blue assay. The lowest mean value of glycosaminoglycans in synovial fluid was measured in the control group. Significantly higher glycosaminoglycan content (P < 0.05) was found in synovial fluid isolated from obese dogs compared to control dogs. Furthermore, we observed an agerelated trend, in which the highest mean values were reached either in old dogs or pups. Despite the absence of significant differences in glycosaminoglycan values among dogs suffering from various types of secondary secondary osteoarthritis, the highest mean values were measured in fragmented coronoid processus group. Our data suggest that abnormally increased body weight has an impact on glycosaminoglycan concentration in synovial fluid which may imply faster degradation and turnover of joint cartilage. Such observation has not yet been published in veterinary medicine.

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“…AP activity in the synovial fluid of equine OA joints correlates with articular damage (109). However, the enzyme was not detected by immunohistochemistry in the synovial tissue of OA patients (110).…”

Section: Dysregulated Eppi/epi Production In Pathologymentioning

confidence: 96%

Extracellular nucleotide metabolism and signaling in the pathophysiology of articular cartilage

Picher¹,

Graff²,

Lee³

2003

Arthritis & Rheumatism

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Cross-sectional comparison of synovial fluid biochemical markers in equine osteoarthritis and the correlation of these markers with articular cartilage damage

Cited by 72 publications

References 24 publications

Aggrecan and Cartilage Oligomeric Matrix Protein in Serum and Synovial Fluid of Patients with Knee Osteoarthritis

Aggrecan and Cartilage Oligomeric Matrix Protein in Serum and Synovial Fluid of Patients with Knee Osteoarthritis

Measurement of glycosaminoglycans in canine synovial fluid and its correlation with the cause of secondary osteoarthritis, age and body weight

Extracellular nucleotide metabolism and signaling in the pathophysiology of articular cartilage

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