Cross-sectional association between gamma-glutamyl transferase and hyperuricaemia: the China Multi-Ethinic Cohort (CMEC) study

Abstract

ObjectivesSeveral studies have demonstrated the association between gamma-glutamyl transferase (GGT) and hyperuricaemia, but little is known about such relation in less-developed ethnic minority regions.DesignWe cross-sectionally analysed data from the China Multi-Ethnic Cohort (Yunnan region).SettingCross-sectional study.Participants22 020 participants aged 30–79 years from Han ethnicity, Yi ethnicity and Bai ethnicity.OutcomesThe serum level of uric acid, GGT and other metabolic parameters were tested. Weight, height and blood pressure were measured. Smoking, drinking, ethnicity, education and medical history were obtained from questionnaires.ResultsIn the crude model, compared with the lowest quintile, the second, third, fourth and fifth quintiles of serum GGT exhibited a positive association with hyperuricaemia risk (OR=1.69, 2.90, 4.34 and 7.70, 95% CI=1.42 to 2.01, 2.47 to 3.42, 3.71 to 5.09 and 6.60 to 8.98, respectively, p-trend<0.0001). In fully adjusted model, compared with the lowest quintile, the second, third, fourth and fifth quintiles of serum GGT also exhibited a positive association with hyperuricaemia risk (OR=1.26, 1.68, 2.02 and 3.02, 95% CI=1.04 to 1.51, 1.40 to 2.00, 1.69 to 2.42 and 2.51 to 3.64, respectively, p-trend<0.0001). Logistic regression model was conducted separately in ethnic groups. Compared with first quintile, the highest GGT level were related to higher risk of hyperuricaemia in three ethnic groups (OR (95% CI): 2.89 (2.26 to 3.68), 2.81 (1.93 to 4.11) and 3.04 (1.91 to 4.84) for Han, Yi and Bai ethnicity, respectively, p-trend <0.0001). The relationship between GGT and hyperuricaemia was also observed in different age groups or gender groups.ConclusionsHigh serum GGT level was related to a higher risk of hyperuricaemia in less-developed ethnic minority regions in China.

Association between adherence to the Dietary Approaches to Stop Hypertension diet and serum uric acid

“…Moreover, the high visceral fat content and strong stimulation of fatty acid synthesis is accompanied by hyper-metabolic conversion of ribose 5-phosphate in overweight /obese individuals, resulting in increased uric acid production 47 , as well as lower insulin sensitivity in overweight/obese individuals 48 , causing enhanced renal tubular re-absorption of uric acid and reduced uric acid excretion 49 . Epidemiological studies have also indicated that overweight and obesity are risk factors for elevated SUA 32 , 50 .…”

Life’s Essential 8, Life’s Simple 7 and the odds of hyperuricaemia: results from the China Multi-Ethnic Cohort Study

“…The prevalence of HUA in China ranges from 13.7 to 18.8% in different regions [ 5 ]. Of note, the prevalence of HUA is mostly driven by lifestyle, such as an unhealthy diet [ 6 ], sleep deprivation [ 7 ] or unfavourable lipid profiles [ 8 ].…”