Cross-sectional and longitudinal study of association between circulating thiobarbituric acid-reacting substance levels and clinicobiochemical parameters in 1,178 middle-aged Japanese men - the Amagasaki Visceral Fat Study

Okauchi, Yukiyoshi; Kishida, Ken; Funahashi, Tohru; Noguchi, Midori; Ogawa, Takumi; Okita, Keisuke; Iwahashi, Hiromi; Ohira, Tetsuya; Imagawa, Akihisa; Nakamura, Tadashi; Shimomura, Iichiro

doi:10.1186/1743-7075-8-82

Cited by 16 publications

(19 citation statements)

References 27 publications

(40 reference statements)

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“…The association between adiponectin and glutathione (GSH) remains to be fully elucidated, but an association between adiponectin and the ratio of oxidized and reduced GSH has been suggested (). An inverse correlation between adiponectin and measures of lipid peroxidation has been reported in some studies (), but not all ().…”

Section: Introductionmentioning

confidence: 84%

Oxidative stress and inflammatory markers in relation to circulating levels of adiponectin

Gustafsson

Lind

Söderberg

et al. 2013

Obesity

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Objective: Previous epidemiological studies together with animal studies have suggested an association between adiponectin and oxidative stress and inflammation, but community-based studies are lacking. Our objective was to investigate the relative importance of oxidative stress and inflammatory markers, representing different pathways in relation to adiponectin. Design and Methods: In a cross-sectional sample of 929 70-year-old individuals (50% women) of the Prospective Investigation of the Vasculature in Uppsala Seniors study, relations between serum adiponectin and oxidative stress [conjugated dienes (CD), homocysteine, total antioxidant capacity, oxidized low-density lipoprotein (OxLDL), OxLDL antibodies, baseline CD of LDL, glutathione (GSH), total glutathione (TGSH), glutathione disulfide], circulation interleukins (IL-6, IL-8), other cytokines [tumor necrosis factor a, monocyte chemotactic protein-1 (MCP-1), epidermal growth factor (EGF), vascular endothelial growth factor], cell adhesion molecules (vascular cell adhesion molecule-1, intercellular adhesion molecule-1, E-selectin, P-selectin, L-selectin), and systemic inflammatory markers [C-reactive protein (CRP), leukocyte count] in separate models were investigated. Results: In age-and sex-adjusted, as well as multivariable-adjusted models, adiponectin was significantly and positively associated with GSH, log TGSH, whereas an inverse association was observed for CD and log EGF. An inverse association between adiponectin and MCP-1, log E-selectin, and log CRP was significant in age-and sex-adjusted models, but not in multivariable-adjusted models. Conclusions: Our results imply that higher levels of adiponectin are associated with a more beneficial oxidative stress profile, with higher levels of principal anti-oxidative GSH and total GSH together with lower levels of lipid peroxidation, possibly through shared pathways. Further studies are needed to investigate whether changes in the oxidative stress profile may be a mechanism linking adiponectin with type 2 diabetes and/or cardiovascular disease.

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Section: Introductionmentioning

confidence: 84%

Oxidative stress and inflammatory markers in relation to circulating levels of adiponectin

Gustafsson

Lind

Söderberg

et al. 2013

Obesity

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“…Obesity is associated with decreased adiponectin, increased TNF-α, increased oxidative stress and ROS 110 . Oxidative stress leads to decreased circulating adiponectin possibly due to ROS-induced increases in T-cadherin expression which binds adiponectin 111 .…”

Section: Macrophage and Adipocyte Dysfunction In Obese Adipose Tissuementioning

confidence: 99%

Macrophage functions in lean and obese adipose tissue

2017

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Summary Interactions between macrophages and adipocytes influence both metabolism and inflammation. Obesity-induced changes to macrophages and adipocytes lead to chronic inflammation and insulin resistance. This paper reviews the various functions of macrophages in lean and obese adipose tissue and how obesity alters adipose tissue macrophage phenotypes. Metabolic disease and insulin resistance shift the balance between numerous pro- and anti-inflammatory regulators of macrophages and create a feed-forward loop of increasing inflammatory macrophage activation and worsening adipocyte dysfunction. This ultimately leads to adipose tissue fibrosis and diabetes. The molecular mechanisms underlying these processes have therapeutic implications for obesity, metabolic syndrome, and diabetes.

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“…The mayor clinical evidence available about the association between fat distribution, including VAF, and OS focus on markers of oxidative damage and its effects on mitochondrial activity processes. 13,14,64 Little is the evidence related to antioxidant defenses. Heval et al reports that glutathione concentration correlates inversely with the amount of various fat deposits, such as gynoid fat, android fat, and total fat.…”

Section: Discussionmentioning

confidence: 99%

“…12 An increase in lipoperoxidation (LPO), and 8-epiprostaglandin F2 (8-iso-PGF2α) products and their correlation with VAF in patients with metabolic syndrome front non-obese subjects have previously demonstrated. [13][14][15] The main antioxidants that neutralize ROS are catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx). 16,17 Recently, the inverse relationship of SOD enzyme activity with VAF in obese men was reported.…”

Section: Introductionmentioning

confidence: 99%

<p>The Effect of Visceral Abdominal Fat Volume on Oxidative Stress and Proinflammatory Cytokines in Subjects with Normal Weight, Overweight and Obesity</p>

García-Sánchez

Gámez-Nava

Cruz

et al. 2020

DMSO

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Purpose: The increase of visceral abdominal fat (VAF) and oxidative stress (OS) are independent predictors for cardiovascular risk. This study aimed to determine the association of VAF with proinflammatory cytokines, oxidants, antioxidants, and oxidative damage to DNA in subjects with normal weight, overweight, and obesity. Patients and Methods: A cross-sectional study that included 21 men and 71 women who attended for a medical check-up was conducted. Dual-energy X-ray absorptiometry (DXA) was used to measure the VAF volume. ELISA and colorimetric techniques were used for chemical analysis.Results: Low activity of superoxide dismutase (SOD) was found in overweight and obese subjects compared to the normal weight group (p=0.005). In contrast, the activity of glutathione peroxidase (GPx) was higher in the overweight and obesity groups compared to the normal weight subjects (p=0.017). The total antioxidant capacity (TAC) was also increased in the overweight group compared to the normal weight group (p=0.04). According to the volume of VAF, the levels of tumor necrosis factor alfa and interleukin 6 showed no differences between subjects with normal and high VAF. Subjects with high VAF show higher levels of 8-isoprostans compared to normal VAF group (p=0.039). Less concentration of 8-oxoguanine-DNA-N-glycosylase-1 (hOGG1) was found in the high VAF group (p=0.032) compared to the normal VAF subjects. VAF was positively correlated with lipoperoxides (LPO) (r=0.27, p<0.05) and 8-isoprostanes (r=0.25, p<0.05). We also found correlations between oxidative stress markers and anthropometric ratios for intra-abdominal fat. The waist-hip ratio was positively correlated with LPO (r=0.30, p<0.05) and TAC (r=0.24, p<0.05). Conclusion: These findings suggest that the predominantly oxidative damage associated with VAF in overweight or obesity is lipoperoxidation and oxidative DNA damage. Alterations in endogenous antioxidant defenses may not be linked to the amount of VAF.

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Cross-sectional and longitudinal study of association between circulating thiobarbituric acid-reacting substance levels and clinicobiochemical parameters in 1,178 middle-aged Japanese men - the Amagasaki Visceral Fat Study

Cited by 16 publications

References 27 publications

Oxidative stress and inflammatory markers in relation to circulating levels of adiponectin

Oxidative stress and inflammatory markers in relation to circulating levels of adiponectin

Macrophage functions in lean and obese adipose tissue

<p>The Effect of Visceral Abdominal Fat Volume on Oxidative Stress and Proinflammatory Cytokines in Subjects with Normal Weight, Overweight and Obesity</p>

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