Cross‐Reactive HL‐A Antibodies; Absorption and Immunization Studies

Thorsby, E.; Kjerbye, K. E.; Bratlie, A.

doi:10.1111/j.1423-0410.1970.tb01473.x

Cited by 33 publications

(10 citation statements)

References 6 publications

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“…In our experiments HL-A5 is the stimulating antigen, and this may explain the stronger reactivity against this antigen compared to 4C*. More studies of serum Li have strongly indicated that its group of antibodies against HL-A5 and4C* consists of two separable antibody components; monospecific anti HL-A5 antibodies and cross-reacting antibodies against HL-A5 and 4C* [18].…”

Section: Discussionmentioning

confidence: 97%

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New HL-A Alleles

Thorsby¹,

Kissmeyer-Nielsen²

1970

Vox Sanguinis

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By immunization within specially selected donor-recipient pairs it was possible to produce antibodies against three new HL-A antigens. One of these was later found identical to Dal7, the other two are called Li of the LA series, and LND of the Four series of antigens. The antigens behaved in population and family studies as if they were determined by alleles at the LA and Four sub-loci. The present status of the HL-A system seems to be that 8 La alleles and 9 Four alleles are well defined. However, unknown HL-A antigens of low frequency still remain to be identified. The reported method seems to be very useful for this purpose.

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Section: Discussionmentioning

confidence: 97%

“…It was, therefore, found impossible to produce a monospecific anti-Li serum by absorp tion experiments. The explanation may be that the antibodies in this case are directed against an antigenic structure that is similar to the antigens Li and Dal7, only cross-reacting antibodies are produced [18].…”

Section: Discussionmentioning

confidence: 99%

New HL-A Alleles

Thorsby¹,

Kissmeyer-Nielsen²

1970

Vox Sanguinis

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“…As the majority of the tested anti sera contains cross-reacting antibodies, the reactions among two or more antigens which were found by Kissmeyer-Nielsen and Thorsby [11], Thorsby et al [21], and Mayr [13], are of decisive significance. By the influence of a proteolytic enzyme an antigen which can be absorbed, but which does not react cytotoxically can get the ability for a cytotoxic reaction, perhaps because complement components can get effective by a change of the receptor region.…”

Section: Resultsmentioning

confidence: 99%

“…(2) Two different antigens have a part in common, inducing the formation of antibodies, which overlap in their functions [1,19,21].…”

Section: Discussionmentioning

confidence: 99%

The Possibility of Influencing Histocompatibility Antigens by Proteolytic Enzymes

Heumann¹,

Bube²,

Siebel³

1973

Vox Sanguinis

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Five different proteolytic enzymes were tested, partly in commercial concentrations, against selected lymphocyte samples. By this selected material the increased sensibility of ficin, which has already been proved by other authors, was verified, and by the rest of the enzymes, most of all by papain, higher grades of injury were proved in the cytotoxic test. Defined cell samples allow statements about the specificity of the enzymes. It is referred to the possibility of identifying cross-reacting antigens and antigens which cannot be seized with the standard technique.

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“…It is generally assumed that HLA-C molecules have the same function as HLA-A and -B but this has never been formally demonstrated. Despite the fact that HLA-C antigens have been described (11)(12)(13)(14)(15), information on their functional properties is extremely scarce. In vitro and in vivo CTLs can be generated against 17).…”

mentioning

confidence: 99%

Immunological function of HLA-C antigens in HLA-Cw3 transgenic mice.

Dill

Kievits

Koch

et al. 1988

Proc. Natl. Acad. Sci. U.S.A.

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The human major histocompatibility complex encodes three classical class I antigens, HLA-A, -B, and -C. Of these HLA-A and -B act as strong transplantation antigens and as restriction molecules for recognition of foreign antigen by cytotoxic T lymphocytes. In contrast, little is known about HLA-C and it is not clear whether IILA-C has the same functional properties as HLA-A and -B. Transgenic C57BL/6 mice expressing the HLA-Cw3 gene were established. Functional studies demonstrated that transgenic skin was rapidly rejected by normal C57BL/6 mice and that cytotoxic T lymphocytes generated by immunization of the Cw3 transgenic mice with influenza and Sendai virus were restricted by the Cw3 molecule. These data suggest that HLA-Cw3 has immunological functions comparable to those of HLA-A and -B.

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Cross‐Reactive HL‐A Antibodies; Absorption and Immunization Studies

Cited by 33 publications

References 6 publications

New HL-A Alleles

New HL-A Alleles

The Possibility of Influencing Histocompatibility Antigens by Proteolytic Enzymes

Immunological function of HLA-C antigens in HLA-Cw3 transgenic mice.

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