Cross-national clinical and functional remission rates: Worldwide Schizophrenia Outpatient Health Outcomes (W-SOHO) study

Haro, Josep María; Novick, Diego; Bertsch, Jordan; Karagianis, Jamie; Dossenbach, M.; Jones, Peter B.

doi:10.1192/bjp.bp.110.082065

Cited by 155 publications

(85 citation statements)

References 41 publications

(51 reference statements)

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“…The total sample of patients was 14 192, including over half of the patients from the W‐SOHO study that reported a small, but significant relationship between age at onset and the outcome (Haro et al, 2011). One study reported in 2 papers indicated an opposite significant relationship between the variables (Bland & Parker, 1978; Bland et al, 1976).…”

Section: Resultsmentioning

confidence: 99%

Age at onset and the outcomes of schizophrenia: A systematic review and meta‐analysis

Immonen

Jääskeläinen

Korpela

et al. 2017

Early Intervention Psych

214

116

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The aim of this study was to analyse the effect of age at onset on the long‐term clinical, social and global outcomes of schizophrenia through a systematic review and a meta‐analysis. Original studies were searched from Web of Science, PsycINFO, Pubmed and Scopus, as well as manually. Naturalistic studies with at least a 2‐year follow‐up were included. Of the 3509 search results, 81 articles fulfilled the inclusion criteria. The meta‐analysis was performed in Stata as a random‐effect analysis with correlation coefficients between age at onset and the outcomes (categorized into remission, relapse, hospitalization, positive symptoms, negative symptoms, total symptoms, general clinical outcome, employment, social/occupational functioning and global outcome). There was a statistically significant (P < .05) correlation between younger age at onset and more hospitalizations (number of studies, n = 9; correlation, r = 0.17; 95% confidence interval, CI 0.09–0.25), more negative symptoms (n = 7; r = 0.14; 95% CI 0.01–0.27), more relapses (n = 3; r = 0.11; 95% CI 0.02–0.20), poorer social/occupational functioning (n = 12; r = 0.15; 95% CI 0.05–0.25) and poorer global outcome (n = 13; r = 0.14; 95% CI 0.07–0.22). Other relationships were not significant. This was the first systematic review of the effects of age at onset on the long‐term outcomes of schizophrenia. The results show that age at onset has a small, but significant impact on some of the outcomes of schizophrenia.

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Section: Resultsmentioning

confidence: 99%

Age at onset and the outcomes of schizophrenia: A systematic review and meta‐analysis

Immonen

Jääskeläinen

Korpela

et al. 2017

Early Intervention Psych

214

116

View full text Add to dashboard Cite

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“…22 Recent report from SOHO (Schizophrenia Outpatient Health Outcome), including 10 studies from Western Europe and 27 studies from 4 different continents, suggests that clinical remission was significantly lower in Europe compared with other regions, but this difference was not found for functional remission. 38 More research from the developing world will help resolve these issues, and in this context, it is gratifying to see more high quality outcome studies now emerging from these sites. 38,39 In the meta-analysis of Hegarty et al 15 studies, using broad non-Kraepelinian criteria showed better outcomes than those using narrow Kraepelinian criteria.…”

Section: Discussionmentioning

confidence: 99%

“…38 More research from the developing world will help resolve these issues, and in this context, it is gratifying to see more high quality outcome studies now emerging from these sites. 38,39 In the meta-analysis of Hegarty et al 15 studies, using broad non-Kraepelinian criteria showed better outcomes than those using narrow Kraepelinian criteria. We did not find clear support for this finding.…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review and Meta-Analysis of Recovery in Schizophrenia

Jääskeläinen

Juola

Hirvonen

et al. 2012

Schizophrenia Bulletin

732

496

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Objective: Our primary aims were (a) to identify the proportion of individuals with schizophrenia and related psychoses who met recovery criteria based on both clinical and social domains and (b) to examine if recovery was associated with factors such as gender, economic index of sites, and selected design features of the study. We also examined if the proportions who met our definition of recovery had changed over time. Method: A comprehensive search strategy was used to identify potential studies, and data were extracted for those that met inclusion criteria. The proportion who met our recovery criteria (improvements in both clinical and social domains and evidence that improvements in at least 1 of these 2 domains had persisted for at least 2 years) was extracted from each study. Meta-regression techniques were used to explore the association between the recovery proportions and the selected variables. Results: We identified 50 studies with data suitable for inclusion. The median proportion (25%-75% quantiles) who met our recovery criteria was 13.5% (8.1%-20.0%). Studies from sites in countries with poorer economic status had higher recovery proportions. However, there were no statistically significant differences when the estimates were stratified according to sex, midpoint of intake period, strictness of the diagnostic criteria, duration of follow-up, or other design features. Conclusions: Based on the best available data, approximately, 1 in 7 individuals with schizophrenia met our criteria for recovery. Despite major changes in treatment options in recent decades, the proportion of recovered cases has not increased.Key words: schizophrenia/psychosis/recovery/outcome studies/prognosis/epidemiology It is widely accepted that a proportion of individuals who develop schizophrenia have a favorable prognosis. Symptoms can abate over time, and a proportion of those with schizophrenia attain good outcomes on a range of clinical and functional outcomes (eg, education, employment, and relationships). The precise proportion of cases that have favorable outcomes is less clearly understood. To a large degree, this relates to uncertainty about how to measure multifaceted outcomes such as "recovery." Considering how much research attention has been allocated to exploring the onset of psychosis (eg, prodrome and early psychosis), it is appropriate that a comparable degree of research scrutiny also be accorded to the recovery of psychosis.

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“…Comparison results were drawn from the literature, outside the primary setting. We reviewed prospective and retrospective cohort studies of the natural course of schizophrenia and bipolar disorder from low-income countries (Thirthalli et al, 2009, Haro et al, 2011, Ran et al, 2001) and selected one from Ethiopia (Kebede et al, 2005) for being closest in context.…”

Section: Methodsmentioning

confidence: 99%

Cost-effectiveness of the Mental Health and Development model for schizophrenia-spectrum and bipolar disorders in rural Kenya

et al. 2015

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Authors' contributions: SR, CL, JK, MW, SKW and SM designed the study; VdM, MK, and DM proposed the framework for economic analysis; VdM conducted the analysis and drafted the article; all authors revised the article and approved the final version. Funding:The intervention was funded by the European Commission's Non-State Actor funding stream (DCI-NSAPVD/2008/156-918) and the UK Department for International Development's Civil Society Challenge Fund (CSCF 450).Competing Interests: Shoba Raja, Joyce Kingori, Milka Waruguru and Saju Mannarath are employees of BasicNeeds. Abstract (164 words)Background. The treatment gap for serious mental disorders across low-income countries is estimated to be 89%. The model for Mental Health and Development (MHD) offers community-based care for people with mental disorders in eleven low-and middle-income countries.

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Cross-national clinical and functional remission rates: Worldwide Schizophrenia Outpatient Health Outcomes (W-SOHO) study

Abstract: Clinical outcomes of schizophrenia seem to be worse in Europe compared with other regions. However, functional remission follows a different pattern.

Cited by 155 publications

References 41 publications

Age at onset and the outcomes of schizophrenia: A systematic review and meta‐analysis

Age at onset and the outcomes of schizophrenia: A systematic review and meta‐analysis

A Systematic Review and Meta-Analysis of Recovery in Schizophrenia

Cost-effectiveness of the Mental Health and Development model for schizophrenia-spectrum and bipolar disorders in rural Kenya

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