Objective: Our primary aims were (a) to identify the proportion of individuals with schizophrenia and related psychoses who met recovery criteria based on both clinical and social domains and (b) to examine if recovery was associated with factors such as gender, economic index of sites, and selected design features of the study. We also examined if the proportions who met our definition of recovery had changed over time. Method: A comprehensive search strategy was used to identify potential studies, and data were extracted for those that met inclusion criteria. The proportion who met our recovery criteria (improvements in both clinical and social domains and evidence that improvements in at least 1 of these 2 domains had persisted for at least 2 years) was extracted from each study. Meta-regression techniques were used to explore the association between the recovery proportions and the selected variables. Results: We identified 50 studies with data suitable for inclusion. The median proportion (25%-75% quantiles) who met our recovery criteria was 13.5% (8.1%-20.0%). Studies from sites in countries with poorer economic status had higher recovery proportions. However, there were no statistically significant differences when the estimates were stratified according to sex, midpoint of intake period, strictness of the diagnostic criteria, duration of follow-up, or other design features. Conclusions: Based on the best available data, approximately, 1 in 7 individuals with schizophrenia met our criteria for recovery. Despite major changes in treatment options in recent decades, the proportion of recovered cases has not increased.Key words: schizophrenia/psychosis/recovery/outcome studies/prognosis/epidemiology It is widely accepted that a proportion of individuals who develop schizophrenia have a favorable prognosis. Symptoms can abate over time, and a proportion of those with schizophrenia attain good outcomes on a range of clinical and functional outcomes (eg, education, employment, and relationships). The precise proportion of cases that have favorable outcomes is less clearly understood. To a large degree, this relates to uncertainty about how to measure multifaceted outcomes such as "recovery." Considering how much research attention has been allocated to exploring the onset of psychosis (eg, prodrome and early psychosis), it is appropriate that a comparable degree of research scrutiny also be accorded to the recovery of psychosis.

The small but mostly consistent correlation between long DUP and poor outcome indicates that early intervention in psychosis may have at least subtle positive effects on the long-term course of illness.

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Background: Online behavior-change programs may increase physical activity in adolescents, but their effects on subjective health and wellbeing are not well known.Purpose: We investigated the effects of a mobile intervention on life satisfaction and self-rated health among young men.Methods: In this population-based study, 496 men (17.8y, SD 0.6y) participated in a 6-month trial. They were randomized into an intervention (n=250) and a control group (n=246). Only the intervention group had access to a tailored mobile service. Life satisfaction and self-rated health were inquired about at baseline and at the end of the trial.Results: Life satisfaction improved in the intervention (p<0.001) and control group (p=0.01). Life satisfaction was most likely to improve among men with low baseline satisfaction (OR 13.8; 95% CI 3.7 -51.8) and mood-related exercise motive (2.5 (1.1 -5.6)). There were no statistically significant changes in self-rated health, but those who reported poor health at baseline (OR 9.6; 95% CI 3.7 -24.9) and improved self-rated fitness during the trial (4.2 (1.5 -11.9)) were more likely to gain improvements in self-rated health.Conclusion: The mobile intervention was most beneficial for men with low life satisfaction and poor self-rated health at baseline. Effect of tailored, mobile intervention on life satisfaction and self-rated health in young men:A population-based, randomized controlled trial (MOPO study) AbstractBackground: Online behavior-change programs may increase physical activity in adolescents, but their effects on subjective health and wellbeing are not well known.Purpose: We investigated the effects of a mobile intervention on life satisfaction and selfrated health among young men.Methods: In this population-based study, 496 men (17.8y, SD 0.6y) participated in a 6month trial. They were randomized into an intervention (n=250) and a control group (n=246). Only the intervention group had access to a tailored mobile service. Life satisfaction and self-rated health were inquired about at baseline and at the end of the trial.Results: Life satisfaction improved in the intervention (p<0.001) and control group (p=0.01). Life satisfaction was most likely to improve among men with low baseline satisfaction (OR 13.8; 95% CI 3.7 -51.8) and mood-related exercise motive (2.5 (1.1 -5.6)). There were no statistically significant changes in self-rated health, but those who reported poor health at baseline (OR 9.6; 95% CI 3.7 -24.9) and improved self-rated fitness during the trial (4.2 (1.5 -11.9)) were more likely to gain improvements in self-rated health.Conclusion: The mobile intervention was most beneficial for men with low life satisfaction and poor self-rated health at baseline.Trial registration: This randomized controlled trial is registered to the clinical trials register NCT01376986.

Highlights • Older adults, who are still active in working life but approaching retirement, differ from other age groups by their health information behaviour • Older adults are the least confident and least motivated to use online health information. • Difficulties in understanding and accepting health information do not necessarily apply to medical records, i.e. health information about oneself • The results do not indicate an obvious linear relationship between age and motivation to use online health information • Personal health information management is a central aspect of health information behaviour

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This cross-sectional population-based study aims at identifying differences in the aspects of everyday health information literacy among young healthy men and adults with an increased risk for metabolic syndrome. Data were collected with a self-assessment-based 10-item screening tool administered at the Finnish Defence Force’s call-ups ( n=2507, response rate 59%) and at health intervention study ( n=571, response rate 98%). Adults with increased risk for metabolic syndrome seemed to value health information but had more difficulty in knowing who to believe in health issues and understanding the terminology used. The difficulties applied especially to respondents 35 years old or over. Men, and especially young men, had lower motivation than women to seek health information. Although the results are indicative, the everyday health information literacy screening tool seems to be useful in revealing areas that health communication should be focused on among different populations.

Antipsychotic medication may associate with brain structure changes. More long-term follow-up studies taking into account illness severity measures are needed to make definitive conclusions.