Cross-modal plasticity in the human thalamus: evidence from intraoperative macrostimulations

Jetzer, A.K.; Morel, Anne; Magnin, M.; Jeanmonod, Daniel

doi:10.1016/j.neuroscience.2009.09.064

Cited by 7 publications

(4 citation statements)

References 84 publications

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“…In our opinion, the pallidothalamic tract may be considered as an ideal target because (1) it is in position to disturb the thalamocortical dynamics, and (2) pallidal overinhibition of the thalamus may have made this pathway useless. Preexisting normal pallidothalamic functions may have been taken over by the powerful corticothalamic network, in the context of extensive redundancy and plastic abilities of the whole thalamocortical system (70). Because the PTT interruption lies upstream of the thalamus, it gives the possibility for the whole thalamocortical system to normalize, thus allowing in principle all symptoms to recede.…”

Section: Pathophysiological Considerationsmentioning

confidence: 99%

MRgFUS Pallidothalamic Tractotomy for Chronic Therapy-Resistant Parkinson's Disease in 51 Consecutive Patients: Single Center Experience

et al. 2020

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Background: There is a long history, beginning in the 1940s, of ablative neurosurgery on the pallidal efferent fibers to treat patients suffering from Parkinson's disease (PD). Since the early 1990s, we undertook a re-actualization of the approach to the subthalamic region, and proposed, on a histological basis, to target specifically the pallidothalamic tract at the level of Forel's field H1. This intervention, the pallidothalamic tractotomy (PTT), has been performed since 2011 using the MR-guided focused ultrasound (MRgFUS) technique. A reappraisal of the histology of the pallidothalamic tract was combined recently with an optimization of our lesioning strategy using thermal dose control.Objective: This study was aimed at demonstrating the efficacy and risk profile of MRgFUS PTT against chronic therapy-resistant PD.Methods: This consecutive case series reflects our current treatment routine and was collected between 2017 and 2018. Fifty-two interventions in 47 patients were included. Fifteen patients received bilateral PTT. The median follow-up was 12 months. Results:The Unified Parkinson's Disease Rating Scale (UPDRS) off-medication postoperative score was compared to the baseline on-medication score and revealed percentage reductions of the mean of 84% for tremor, 70% for rigidity, and 73% for distal hypobradykinesia, all values given for the treated side. Axial items (for voice, trunk and gait) were not significantly improved. PTT achieved 100% suppression of on-medication dyskinesias as well as reduction in pain (p < 0.001), dystonia (p < 0.001) and REM sleep disorders (p < 0.01). Reduction of the mean L-Dopa intake was 55%. Patients reported an 88% mean tremor relief and 82% mean global symptom relief on the operated side and 69% mean global symptom improvement for the whole body. There was no significant change of cognitive functions. The small group of bilateral PTTs at 1 year follow-up shows similar results as compared to unilateral PTTs but does not allow to draw firm conclusions at this point. Gallay et al. MRgFUS PTT for Parkinson's DiseaseConclusion: MRgFUS PTT was shown to be a safe and effective intervention for PD patients, addressing all symptoms, with varying effectiveness. We discuss the need to integrate the preoperative state of the thalamocortical network as well as the psycho-emotional dimension.

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Section: Pathophysiological Considerationsmentioning

confidence: 99%

MRgFUS Pallidothalamic Tractotomy for Chronic Therapy-Resistant Parkinson's Disease in 51 Consecutive Patients: Single Center Experience

et al. 2020

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“…Патофизиологической основой сенситизации ноцицептивных нейронов задних рогов спинного мозга является длительное деполяризующее влияние глутамата и нейрокининов, выделяющихся из центральных терминалей ноцицептивных афферентов вследствие интенсивной постоянной импульсации, идущей из зоны поврежденных тканей [11,12]. Показана также важная роль в этом процессе микроглии и выделяемых ею цитокинов, хемокинов и факторов роста [13]. Возникающая вследствие этого повышенная возбудимость ноцицептивных нейронов задних рогов спинного мозга может сохраняться в течение длительного времени, способствуя расширению площади гиперальгезии, ее распространению на здоровые ткани.…”

Section: материалы сессии рамнunclassified

“…Например, в условиях сенсорной деафферентации изменение рецептивных полей корковых нейронов происходит в первые 15 мин [12]. В последнее время появились сообщения, свидетельствующие о том, что схожие изменения в функционировании нейронов наблюдаются не только в структурах коры больших полушарий, но и в стволе мозга и таламусе [13]. Другим примером функциональной и структурной реорганизации мозга является кросс-модальная пластичность, наиболее ярко проявляющаяся в нейронах вторичных сенсорных и ассоциативных областей коры больших полушарий [19,13].…”

Section: материалы сессии рамнunclassified

“…В последнее время появились сообщения, свидетельствующие о том, что схожие изменения в функционировании нейронов наблюдаются не только в структурах коры больших полушарий, но и в стволе мозга и таламусе [13]. Другим примером функциональной и структурной реорганизации мозга является кросс-модальная пластичность, наиболее ярко проявляющаяся в нейронах вторичных сенсорных и ассоциативных областей коры больших полушарий [19,13]. Кросс-модальная нейропластичность может стать причиной запуска болевых ощущений не только через специализированную ноцицептивную систему, но и другие сенсорные входы, преобразуя сетевую структуру нейронов и их перцептивную способность.…”

Section: материалы сессии рамнunclassified

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Chronic Pain: Medico-Biologic and Sotsio-Economic Aspects

2012

Annals RAMS

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In this article the role of neurobiological, psychological and social factors in pathogenesis of chronic pain is analyzed. The chronic pain is considered not as a symptom of damage of tissue and as independent illness due to non-adequate neuroplasticity of systems involved into regulation of pain sensitivity. The major role in development and maintenance of chronic pain is devoted to the primary genetically determined and/or secondary disturbance of interaction between nociceptive and antinociceptive systems at various levels - from peripheral neuron to central structures – that provides pain perception and painful behaviour development.

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Current Views on Chronic Pain and Its Relationship to the State of Sleep

Кукушкин

Полуэктов

2018

Neurosci Behav Physi

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Cross-modal plasticity in the human thalamus: evidence from intraoperative macrostimulations

Cited by 7 publications

References 84 publications

MRgFUS Pallidothalamic Tractotomy for Chronic Therapy-Resistant Parkinson's Disease in 51 Consecutive Patients: Single Center Experience

MRgFUS Pallidothalamic Tractotomy for Chronic Therapy-Resistant Parkinson's Disease in 51 Consecutive Patients: Single Center Experience

Chronic Pain: Medico-Biologic and Sotsio-Economic Aspects

Current Views on Chronic Pain and Its Relationship to the State of Sleep

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