Cross‐Metathesis

Synthesis of 2-aminosuberic acid derivatives as components of some histone deacetylase inhibiting cyclic tetrapeptides

“…The corresponding reaction of 11 with benzyl acrylate ( 13b ) proceeded with similar facility, yield and isomeric composition. Although the cross-metathesis reaction with α,ß-unsaturated esters and ketones have been extensively studied, the corresponding reactions with amides and anilides are less documented [ 28 ]. An elegant solution to one of this problems is the use of acryloyl chloride as CM partner followed by functionalization of the cross product [ 29 ].…”

Diversity-oriented synthesis of analogues of the novel macrocyclic peptide FR-225497 through late stage functionalization

“…We thought that a cross metathesis reaction [ 16 – 17 ] on a macrocyclic template would constitute a direct approach for grafting the pendant alkyl chain of 1 , as demonstrated retrosynthetically in Fig. 2 .…”

Editorial of Special Issue Ruthenium Complex: The Expanding Chemistry of the Ruthenium Complexes

“…With introduction of the new generations of highly active and chemoselective Ru metathesis catalysts endowed with high tolerance towards many functionalities and good stability in the presence of air, moisture and various solvents, including water-containing systems [231,232,233,234,235,236,237,238,239], the diversification of metathesis reactions experienced a strong impetus [240,241,242,243,244,245]. Among metathesis reactions, cross-metathesis (CM) [246,247,248,249] and ring-closing metathesis (RCM) [250,251,252,253,254] have become the most encountered strategies for the synthesis of linear and branched, or carbocyclic and heterocyclic compounds. Ru-catalyzed enyne metathesis (EYRCM) provided an elegant and productive way to obtain small, medium and large cyclic molecules [255].…”