Cross-linking IgE augments human conventional dendritic cell production of CC chemokine ligand 28

Khan, Sadia Hayat; Grayson, Mitchell H.

doi:10.1016/j.jaci.2009.09.038

Cited by 30 publications

(24 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cross-linking of FcεRI by anti-viral IgE led to production of CCL28, a chemokine that attracted Th2 cells in an antigen non-specific fashion 7, 8. While these initial observations were made in mice, we have shown that the cDC FcεRI-CCL28 axis appears operative in humans 9. Further, it has been shown that expression of FcεRI on human peripheral blood cDC is increased by respiratory viral infection 10.…”

Section: Introductionmentioning

confidence: 78%

Development of atopy by severe paramyxoviral infection in a mouse model

Cheung

Ehlenbach

Kitchens

et al. 2010

Annals of Allergy, Asthma & Immunology

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 78%

Development of atopy by severe paramyxoviral infection in a mouse model

Cheung

Ehlenbach

Kitchens

et al. 2010

Annals of Allergy, Asthma & Immunology

Self Cite

View full text Add to dashboard Cite

show abstract

“…In this way, dendritic cells could attract Tregs through the production of chemokines in lieu of the target stroma. In support of this view, dendritic cells have the ability to produce CCL28, 79 which actively recruits CD103 + Tregs through CCR10 in inflamed human liver. 80 In the gut, CCR10 expression on immigrating Tregs does play a role in Treg recruitment.…”

Section: Treg Migration To Peripheral Tissuesmentioning

confidence: 93%

Regulatory T-cell Trafficking: From Thymic Development to Tumor-Induced Immune Suppression

Mailloux

Young

2010

Crit Rev Immunol

View full text Add to dashboard Cite

Regulatory T cells (Tregs) have become a priority for many investigators in immunology due to their potent immunosuppressive and tolerogenic effects. While Treg activity is required for normal immune homeostasis, dysregulation of their numbers can induce autoimmunity or aid in the pathogenesis of disease. Therefore, great effort has been made to understand the mechanisms by which Tregs accumulate in different areas of the body. Like other lymphocytes, Tregs migrate in response to a network of chemotactic stimuli involving chemokines, chemokine receptors, integrins, and their corresponding ligands. However, many of these stimuli are exclusive to Tregs, inducing their migration while leaving conventional populations unaffected. It is these selective stimuli that result in increased ratios of Tregs among conventional effector populations, leading to changes in immune suppression and homeostasis. This review explores selective Treg trafficking during thymic Treg development, migration to secondary lymphoid tissues and emigration into the periphery during homeostatic conditions, inflammation, and the tumor microenvironment, placing emphasis on stimuli that selectively recruits Tregs to target locations.

show abstract

“…Cross-linking FcεRI bound IgE on cDC leads to recruitment of IL-13 producing Th2 cells driving the atopic response. We have shown in humans that cross-linking IgE on cDC produces CCL28, the same Th2 chemoattractant critical for the mouse model [9]. Although adult human cDC and pDC are known to express FcεRI, very little is known about induction and regulation of this receptor on human cDC and pDC from children.…”

Section: Introductionmentioning

confidence: 99%

Expression of High-Affinity IgE Receptor on Human Peripheral Blood Dendritic Cells in Children

Vasudev¹,

Cheung²,

Pincsak³

et al. 2012

PLoS ONE

Self Cite

View full text Add to dashboard Cite

BackgroundIn a mouse model of viral induced atopic disease, expression of FcεRI on dendritic cells is critical. While adult human conventional (cDC) and plasmacytoid (pDC) dendritic cells have been shown to express FcεRI, it is not known if this receptor is expressed in childhood and how its expression is governed by IgE.MethodsFollowing informed consent of subjects (n = 27, aged 12–188 months), peripheral blood was stained for surface expression of CD19, ILT7, CD1c, IgE, FcεRI and analyzed by flow cytometry (cDC: CD19− ILT7− CD1c+; pDC: CD19− ILT7+ CD1c−). Total and specific serum IgE levels to food and inhalant allergens were determined by ImmunoCAP, and the relationship between FcεRI expression on dendritic cells and sensitization, free IgE, cell bound IgE, and age was determined.ResultsIndependent of sensitization status, FcεRI expression was noted on cDC and pDC as early as 12 months of age. Serum IgE level correlated with expression of FcεRI on cDC, but not pDC. Based on the concentration of IgE, a complex relationship was found between surface bound IgE and expression of FcεRI on cDC. pDC exhibited a linear relationship of FcεRI expression and bound IgE that was consistent through all IgE concentrations.ConclusionsIn children, FcεRI expression on cDC and pDC is modulated differently by serum and cell bound IgE. IgE governance of FcεRI expression on cDC depends upon a complex relationship. Further studies are needed to determine the functional roles of FcεRI on cDC and pDC.

show abstract

Cross-linking IgE augments human conventional dendritic cell production of CC chemokine ligand 28

Cited by 30 publications

References 9 publications

Development of atopy by severe paramyxoviral infection in a mouse model

Development of atopy by severe paramyxoviral infection in a mouse model

Regulatory T-cell Trafficking: From Thymic Development to Tumor-Induced Immune Suppression

Expression of High-Affinity IgE Receptor on Human Peripheral Blood Dendritic Cells in Children

Contact Info

Product

Resources

About