Cross-linked thermosensitive nanohydrogels for ocular drug delivery with a prolonged residence time and enhanced bioavailability

Wen, Yu; Jia, Huanhuan; Mo, Zhenjie; Zheng, Kangyu; Chen, Shihong; Ding, Yuanyuan; Zhang, Yan; Wen, Yuqin; Xie, Qiuling; Qiu, Jindi; Wu, Hao; Ni, Qingchun; Ban, Junfeng; Lu, Zhufen; Chen, Yanzhong

doi:10.1016/j.msec.2020.111445

Cited by 12 publications

(4 citation statements)

References 34 publications

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“…Wen Y. et al [ 67 ] extended the residence time of dexamethasone in the cornea by incorporating it into a nano-hydrogel based on kolliphor P188, kolliphor P407, and polycarbophil. The nano-hydrogel was obtained by the cold solution method at 4 °C.…”

Section: Gels In Ophthalmologymentioning

confidence: 99%

Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

et al. 2023

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Modified polymeric gels, including nanogels, which play not only the role of a bioinert matrix, but also perform regulatory, catalytic, and transport functions due to the active fragments introduced into them, can significantly advance the solution to the problem of targeted drug delivery in an organism. This will significantly reduce the toxicity of used pharmaceuticals and expand the range of their therapeutic, diagnostic, and medical application. This review presents a comparative description of gels based on synthetic and natural polymers intended for pharmaceutical-targeted drug delivery in the field of therapy of inflammatory and infectious diseases, dentistry, ophthalmology, oncology, dermatology, rheumatology, neurology, and the treatment of intestinal diseases. An analysis was made of most actual sources published for 2021–2022. The review is focused on the comparative characteristics of polymer gels in terms of their toxicity to cells and the release rate of drugs from nano-sized hydrogel systems, which are crucial initial features for their further possible application in mentioned areas of biomedicine. Different proposed mechanisms of drug release from gels depending on their structure, composition, and application are summarized and presented. The review may be useful for medical professionals, and pharmacologists dealing with the development of novel drug delivery vehicles.

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Section: Gels In Ophthalmologymentioning

confidence: 99%

Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

et al. 2023

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“…Due to the small size of nanomedicines, drug molecules are apt to pass through the layers of barriers of the eye, and the permeability is increased, which improves the transfer efficiency of drugs to the postocular section [41]. At the same time, some materials of nanomedicines have adhesion properties, which will prolong the residence time in the targeted site [42], so the retention rate is high, and frequent administration is not required, which can significantly improve patient compliance. Nanomedicines also exhibit some special physical and chemical properties, such as the high surface area to volume ratio, polyvalent structure, high affinity, and target signal amplification ability [43].…”

Section: Nanocarrier-mediated Treatment Of Posterior Eye Diseasesmentioning

confidence: 99%

Targeted drug delivery vehicles mediated by nanocarriers and aptamers for posterior eye disease therapeutics: barriers, recent advances and potential opportunities

et al. 2022

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Nanomedicine and aptamer have excellent potential in giving play to passive and active targeting respectively, which are considered to be effective strategies in the retro-ocular drug delivery system. The presence of closely adjoined tissue structures in the eye makes it difficult to administer the drug in the posterior segment of the eye. The application of nanomedicine could represent a new avenue for the treatment, since it could improve penetration, achieve targeted release, and improve bioavailability. Additionally, a novel type of targeted molecule aptamer with identical objective was proposed. As an emerging molecule, aptamer shows the advantages of penetration, non-toxicity, and high biocompatibility, which make it suitable for ocular drug administration. The purpose of this paper is to summarize the recent studies on the effectiveness of nanoparticles as a drug delivery to the posterior segment of the eye. This paper also creatively looks forward to the possibility of the combined application of nanocarriers and aptamers as a new method of targeted drug delivery system in the field of post-ophthalmic therapy.

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“…Many studies also deal with the combination of poloxamer 407 and poloxamer 188. Researchers have formulated an in-situ gel with the two types of poloxamer and carbomethylcellulose [ 102 ], while other researchers prepared a nanohydrogel using the two polymers in combination with soy lecithin E200, lecithin oil, glycerol, and polycarbophil [ 103 ], while yet another group used poloxamers 407 and 188 and chitosan gel [ 104 ]. All three studies showed sustained release of the drug.…”

Section: Excipients Used In Ocular Formulations For Modified Drug Deliverymentioning

confidence: 99%

Recent Advances in the Excipients Used for Modified Ocular Drug Delivery

et al. 2021

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In ocular drug delivery, maintaining an efficient concentration of the drug in the target area for a sufficient period of time is a challenging task. There is a pressing need for the development of effective strategies for drug delivery to the eye using recent advances in material sciences and novel approaches to drug delivery. This review summarizes the important aspects of ocular drug delivery and the factors affecting drug absorption in the eye including encapsulating excipients (chitosan, hyaluronic acid, poloxamer, PLGA, PVCL-PVA-PEG, cetalkonium chloride, and gelatin) for modified drug delivery.

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Cross-linked thermosensitive nanohydrogels for ocular drug delivery with a prolonged residence time and enhanced bioavailability

Cited by 12 publications

References 34 publications

Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

Targeted drug delivery vehicles mediated by nanocarriers and aptamers for posterior eye disease therapeutics: barriers, recent advances and potential opportunities

Recent Advances in the Excipients Used for Modified Ocular Drug Delivery

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