Cross-kingdom regulation by dietary plant miRNAs: an evidence-based review with recent updates

Jia, Mingxi; He, Jintao; Bai, Weidong; Lin, Qinlu; Deng, Jing; Li, Wen; Bai, Jie; Fu, Da; Ma, Yu‐Shui; Ren, Jiali; Xiong, ShouYao

doi:10.1039/d1fo01156a

Cited by 22 publications

(21 citation statements)

References 108 publications

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“…Additionally, accumulating evidence indicates that sRNAs can be transferred within cells and tissues and even across species (66) and miRNAs from diet have been proposed to play a role on disease prevention (67,68). Additionally, several authors report that dietary-miRNAs can be absorbed with diet and reach their target mRNAs, both for animal (64,69) and plant (22,65) foodstuffs.…”

Section: Discussionmentioning

confidence: 99%

“…Besides, the latest evidence shows that dietary plant miRNAs can not only be absorbed in the intestine, but also be absorbed and packaged by gastric epithelial cells and then secreted into the circulatory system. The former, leads to consider miRNAs as biologically active plant-derived in a similar way that phytochemicals and, therefore, potentially responsible of food functionality (22).…”

Section: Introductionmentioning

confidence: 99%

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RNA-seq, bioinformatic identification of potential MicroRNA-Like Small RNAs in the edible mushroom Agaricus bisporus and experimental approach for their validation

Marín

Dávalos²,

Kiltschewskij-Brown³

et al. 2021

Preprint

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Although genomes from many edible mushrooms are sequenced, studies on fungal miRNAs are scarce. Most of the bioinformatic tools are designed for plants or animals but fungal miRNAs processing and expression share similarities and differences with both kingdoms. Moreover, since mushroom species such as Agaricus bisporus (white button mushroom) are frequently consumed as food, controversial discussions are still evaluating whether their miRNAs might or might not be assimilated, perhaps within extracellular vesicles (i.e exosomes). Therefore, the A. bisporus RNA-seq was studied in order to identify potential de novo miRNA-like small RNAs (milRNAs) that might allow their later detection in the diet. Results pointed to 1 already known and 37 de novo milRNAss. Three milRNAss were selected for RT-qPCR experiments. Precursors and mature milRNAs were found in the edible parts (caps and stipes) validating the predictions carried out in silico. When their potential gene targets were investigated, results pointed that mostly were involved in primary and secondary metabolic regulation. However, when human transcriptome is used as target, the results suggest that they might interfere with important biological processes related with cancer, infectious process and neurodegenerative diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

RNA-seq, bioinformatic identification of potential MicroRNA-Like Small RNAs in the edible mushroom Agaricus bisporus and experimental approach for their validation

Marín

Dávalos²,

Kiltschewskij-Brown³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…MicroRNAs are a class of small (17-24 nucleotides) and noncoding RNAs with abilities to inhibit mRNA translation (36,37). The latest evidence shows that plant miRNA can be absorbed in the intestine and secreted into the circulatory system (38). The previous report had shown that PELNs deliver miRNA to animals, target mammalian mRNA, and have the potential to mediate a specific tissue response (24,39).…”

Section: Composition Of Pelnsmentioning

confidence: 99%

“…The previous report had shown that PELNs deliver miRNA to animals, target mammalian mRNA, and have the potential to mediate a specific tissue response (24,39). In addition, miRNA in PELNs can be taken up by bacteria and alter microbiome composition and host physiology (28,38,40). But the functions and mechanisms of miRNAs in PELNs are still unknown.…”

Section: Composition Of Pelnsmentioning

confidence: 99%

The Emerging Role of Plant-Derived Exosomes-Like Nanoparticles in Immune Regulation and Periodontitis Treatment

et al. 2022

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Periodontitis is an infectious oral disease, which leads to the destruction of periodontal tissues and tooth loss. Although the treatment of periodontitis has improved recently, the effective treatment of periodontitis and the periodontitis-affected periodontal tissues is still a challenge. Therefore, it is urgent to explore new therapeutic strategies for periodontitis. Natural products show anti-microbial, anti-inflammatory, anti-oxidant and bone protective effects to periodontitis and most of these natural products are safe and cost-effective. Among these, the plant-derived exosome-like nanoparticles (PELNs), a type of natural nanocarriers repleted with lipids, proteins, RNAs, and other active molecules, show the ability to enter mammalian cells and regulate cellular activities. Reports from the literature indicate the great potential of PELNs in the regulation of immune functions, inflammation, microbiome, and tissue regeneration. Moreover, PELNs can also be used as drug carriers to enhance drug stability and cellular uptake in vivo. Since regulation of immune function, inflammation, microbiome, and tissue regeneration are the key phenomena usually targeted during periodontitis treatment, the PELNs hold the promising potential for periodontitis treatment. This review summarizes the recent advances in PELNs-related research that are related to the treatment of periodontitis and regeneration of periodontitis-destructed tissues and the underlying mechanisms. We also discuss the existing challenges and prospects of the application of PELNs-based therapeutic approaches for periodontitis treatment.

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“…The other obvious question concerns the potential of plant miRNAs to become new natural medicine products ( Lukasik and Zielenkiewicz, 2016 ). This subject was recently extensively reviewed e.g., ( Sanchita et al, 2018 ; Jia et al, 2021 ; Li et al, 2021 ; Samad et al, 2021 ; Winkle et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

The Anti-Inflammatory Effect of Cabbage Leaves Explained by the Influence of bol-miRNA172a on FAN Expression

et al. 2022

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Recently, the possibility of cross-kingdom gene expression regulation by miRNAs from other species (“xenomiRs”), specifically from plants, has acquired scientific meaning. Based on the one of oldest methods for dealing with inflammation via the use of cabbage leaf compresses, we investigated the effects of Brassica oleracea derived miR172a on the potential human target gene encoding FAN (Factor Associated with Neutral Sphingomyelinase Activation) protein. In vitro experiments showed a decrease in FAN protein levels in both human and mouse cells transfected with bol-miRNA172a. As the FAN protein mediates inflammatory responses, the potential of miR172a to mitigate the inflammatory process was tested in a mouse model of rheumatoid arthritis. Animal studies showed the decreased oedema of inflamed paws in mouse with rheumatoid arthritis model induced after treatment with miR172a.

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Cross-kingdom regulation by dietary plant miRNAs: an evidence-based review with recent updates

Abstract: As non-coding RNA molecules, microRNAs (miRNAs) are widely known for their critical role in gene regulation. Recent studies have shown that plant miRNAs obtained through dietary oral administration can survive...

Cited by 22 publications

References 108 publications

RNA-seq, bioinformatic identification of potential MicroRNA-Like Small RNAs in the edible mushroom Agaricus bisporus and experimental approach for their validation

RNA-seq, bioinformatic identification of potential MicroRNA-Like Small RNAs in the edible mushroom Agaricus bisporus and experimental approach for their validation

The Emerging Role of Plant-Derived Exosomes-Like Nanoparticles in Immune Regulation and Periodontitis Treatment

The Anti-Inflammatory Effect of Cabbage Leaves Explained by the Influence of bol-miRNA172a on FAN Expression

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