Cross-kingdom interaction between Candida albicans and oral bacteria

Du, Qian; Ren, Biao; Zhou, Xuedong; Zhang, Ling; Xu, Xin

doi:10.3389/fmicb.2022.911623

Cited by 19 publications

(12 citation statements)

References 160 publications

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“…Though the oral mycobiome remains underexplored, several studies point toward mutualistic chemicophysical interactions between oral bacteria and Candida sp. [60][61][62][63]. Thus, oral communities may exhibit a degree of tolerance toward fungi, especially in the setting of restricted fungal virulence that occurs in the oral cavity [64].…”

Section: Discussionmentioning

confidence: 99%

Upper respiratory microbial communities of healthy populations are shaped by niche and age

Zelasko,

Swaney,

Sandstrom

et al. 2024

Preprint

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Background: Alterations in upper respiratory microbiomes have been implicated in shaping host health trajectories, including by limiting mucosal pathogen colonization. However, limited comparative studies of respiratory microbiome development and functioning across age groups have been performed. Herein, we perform shotgun metagenomic sequencing paired with pathogen inhibition assays to elucidate differences in nasal and oral microbiome composition and functioning across healthy 24-month-old infant (n=229) and adult (n=100) populations. Results: We find that beta diversity of nasal and oral microbiomes varies with age, with nasal microbiomes showing greater population-level variation compared to oral microbiomes. Infant microbiome alpha diversity was significantly lower across nasal samples and higher in oral samples, relative to adults. Accordingly, we demonstrate significant differences in genus- and species-level composition of microbiomes between sites and age groups. Antimicrobial resistome patterns likewise varied across body sites, with oral microbiomes showing higher resistance gene abundance compared to nasal microbiomes. Biosynthetic gene clusters encoding specialized metabolite production were found in higher abundance across infant oral microbiomes, relative to adults. Investigation of pathogen inhibition revealed greater inhibition of gram-negative and gram-positive bacteria by oral commensals, while nasal isolates had higher antifungal activity. Conclusions: In summary, we identify significant differences in the microbial communities inhabiting nasal and oral cavities of healthy infants relative to adults. These findings inform our understanding of the interactions impacting respiratory microbiome composition and functioning, with important implications for host health across the lifespan.

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Section: Discussionmentioning

confidence: 99%

Upper respiratory microbial communities of healthy populations are shaped by niche and age

Zelasko,

Swaney,

Sandstrom

et al. 2024

Preprint

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“…The increased biofilm formation caused by the symbiotic interaction of microbial species in the host leads to increased antimicrobial resistance [ 43 ]. The polymicrobial interaction of C. albicans with bacterial pathogens, such as S. aureus , S. mutans , S. gordonii , and S. oralis, is a well-studied example of polymicrobial interaction [ 11 , 44 ]. These bacterial pathogens and C. albicans have frequently been isolated from different host tissues and organs together [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Polymicrobial Biofilms of Candida albicans–Staphylococcus aureus/Streptococcus mutans by Fucoidan–Gold Nanoparticles

et al. 2023

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The polymicrobial proliferation and development of complex biofilm morphologies by bacterial and fungal pathogens in the host are some of the key factors contributing to the failure of antimicrobial treatments. The polymicrobial interaction of Candida albicans and some bacterial species has been extensively studied in both in vitro and in vivo model systems. Alternative strategies for disrupting polymicrobial interaction and biofilm formation are constantly needed. Among several alternative strategies, the use of nanoparticles synthesized using a natural product in the treatment of microbial infection has been considered a promising approach. The current study aimed to synthesize gold nanoparticles (AuNPs) using a natural product, fucoidan, and to test their efficacy against mono and duo combinations of fungal (Candida albicans) and bacterial (Staphylococcus aureus/Streptococcus mutans) biofilms. Several methods were used to characterize and study Fu–AuNPs, including UV-vis absorption spectroscopy, FTIR, FE-TEM, EDS, DLS, zeta potential, and XRD. The concentration-dependent inhibition of early-stage biofilms and the eradication of mature biofilms of single species of C. albicans, S. aureus, and S. mutans have been observed. Early biofilms of a dual-species combination of C. albicans and S. aureus/S. mutans were also suppressed at an increasing concentration of Fu–AuNPs. Furthermore, Fu–AuNPs significantly eradicated the established mature biofilm of mixed species. The treatment method proposed in this study, which involves the use of marine-bioinspired nanoparticles, is a promising and biocompatible agent for preventing the growth of polymicrobial biofilms of bacterial and fungal pathogens.

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“…It is known that the formation of polymicrobial biofilms from cross-kingdom interaction between C. albicans and oral bacteria (such as Streptococcus mutans and Staphylococcus aureus ) predispose in a particular way to the onset of oral candidiasis, and that in these cases the combined administration of povidone-iodine and fluconazole is particularly effective as it is able to completely inhibit the carriage of C. albicans and the development and growth of the biofilm [ 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

An Unconventional Oral Candidiasis in an Immunocompetent Patient

Fusco

Contaldo

Savio

et al. 2023

JoF

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Oral candidiasis (OC) is an opportunistic fungal infection of the oral mucosae, sustained by Candida albicans or other non-albican Candida species (NAC), usually eradicated by conventional antifungals of the classes of azoles, polyenes, or derivative from echinocandins. OC usually occurs under predisposing local or systemic factors. C. lusitaniae is an opportunistic strain that is rarely responsible for human infection and occurs mainly in severe immunocompromised states. The present work reported an unconventional case of OC in an otherwise healthy immunocompetent woman sustained by C. lusitaniae and a multi-resistant strain of C. albicans.

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Cross-kingdom interaction between Candida albicans and oral bacteria

Cited by 19 publications

References 160 publications

Upper respiratory microbial communities of healthy populations are shaped by niche and age

Upper respiratory microbial communities of healthy populations are shaped by niche and age

Inhibition of Polymicrobial Biofilms of Candida albicans–Staphylococcus aureus/Streptococcus mutans by Fucoidan–Gold Nanoparticles

An Unconventional Oral Candidiasis in an Immunocompetent Patient

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