Cross Dehydrogenative Coupling of SF₄-Alkyne with Tetrahydroisoquinolines

Abstract

This study introduces a dual-catalytic method for cross-dehydrogenative coupling (CDC) between tetrahydroisoquinolines and Py-SF 4 -alkyne using visible-light photoredox catalysis. This protocol enables selective C(sp 3 )−H alkynylation, expanding the synthetic toolkit for SF 4 -based molecules. Demonstrating efficiency and substrate versatility, this approach opens new avenues in hexacoordinated tetrafluorinated sulfur chemistry and CDC strategies and holds significant promise for drug discovery and materials science.