“…Additionally, the assessment start time was not the same for all participants. However, as the assessment time varied non-systematically in patients vs. controls, it is unlikely that the assessment time contributed significantly to the results (e.g., circadian effects); BRID data collected at different sites at pseudo-random times-of-day did not differ on any electrophysiological measure according to site (Paul et al 2007). Another possible limitation of the study, as previously indicated, is that the cross-sectional nature of the study precludes the possibility of determining whether the observed disturbances of CNS and ANS function in PD represent state, trait, or vulnerability markers for the disorder.…”