Cross-Conjugated Cyclopentenone Prostaglandins. Recent Advances

Synthesis of Fluorine‐Containing 3‐Aminocyclopent‐2‐enones via Intramolecular Cyclization

“…[14,15] This is, e.g. the structural moiety of prostaglandins, [16] that possess potent anti-inflammatory, antineoplastic, and anti-viral activities. [17] Moreover, conjugated cyclopentenones are privileged motifs for anticancer drugs.…”

Chemical F/J‐Interconversion in the Prostaglandin Family: From Cloprostenol to Its Δ12‐J2 and 15‐Deoxy‐Δ12,14‐J2 Derivatives

“…[3,4] In the past few decades, pharmacologists, medicals and chemists have been showing a steady interest in J-type crossconjugated cyclopentenone prostaglandins (cyPG) that show high and often unique anti-cancer, antiviral, anti-inflammatory, and other properties. [5,6] (Figure 1). For example, 1,15-lactone Δ 12 -PGJ 2 1 is among the most promising cyPGs in the screening against NCI-60 tumor cell lines.…”