Synthesis of Fluorine‐Containing 3‐Aminocyclopent‐2‐enones via Intramolecular Cyclization

Abstract

An optimized protocol for the preparation of fluorine‐containing acyclic enones, which are promising building blocks for the preparation of a large variety of fluorinated compounds was developed. These enones easily react with secondary amines to form fluorine‐containing 3‐aminocyclopent‐2‐enones via 4‐amino‐2,3‐dihydrofuran‐2‐ols. The peculiar mechanism involving an intramolecular electrocyclization as a key step is proposed.

Fluorinated Fragments for OPV

“…Even more peculiar transformation was reported in a follow-up work by Shaitanova et al [91]. By replacing the CF 3 group in the cyclic enone with different combinations of bromines, chlorines, and/or hydrogens etc.…”