Crop coefficient K c is a very useful and widely used variable in evapotranspiration estimation in cropland. Traditional methods in calculating K c are based on field water balance, which is limited by long measurement interval and small study area. In addition, there is the need for K c under new agronomy practice such as plastic mulching and drip irrigation in arid environments. This study calculated and analyzed K c of a drip-irrigated and plastic-mulched cotton field in Aksu Oasis of the arid Tarim River Basin, China, and its relationships with several crop-, soil-and management variables such as relative growth days RGD , leaf area index LAI , extractable soil water ESW , and irrigation, based on two years' observations. The results showed that daily K c varied within the range of 0.08 1.28, with an average of 0.54 for the entire cotton growth season, in 2013 and 2014. Compared to non-mulched condition already published, the K c of mulched cotton for the entire growth season decreased by 16 to 39 . The largest reductions in K c due to plastic mulch were found in the initial and developmental growth stage. K c could be calculated by a third-degree polynomial model in relation to RGD, which was satisfactorily validated and can be used in other studies under the same or similar pedo-climatic and management conditions. Cotton LAI and ESW were found to be important factors influencing K c , particularly their critical values of 3.0 in LAI and 0.5 for ESW. Moreover, the results showed that irrigation significantly increased K c , i.e., 29 on average, partly due to arid advection. This study provided up-to-date and detailed information on cotton crop coefficient under plastic mulching and drip irrigation conditions in arid environment, and it is useful for improved management of agricultural water resources.