Crohn's supraglottitis – The presenting feature of otherwise asymptomatic systemic disease

Managing Head and Neck Malignancy Arising in a Field of Crohn Disease Inflammation: Report of a Case

“…Like intestinal Crohn disease lesions, head and neck mucosal Crohn disease lesions are diverse in appearance, variably containing chronic inflammation, noncaseating granulomas, ulceration, granulation tissue, and/or fibrosis on histologic examination. 1 Our case represents an unusual instance of HNSCC arising in a field of Crohn-disease-related mucosal inflammation. We report it to illustrate the overlap between the clinical and radiologic presentations of laryngeal Crohn disease and malignancy, which confounded our initial diagnosis, staging, and treatment planning.…”

“…Extraintestinal involvement of Crohn disease is well described; it can present as oral ulcers, hepatobiliary disease, arthritis, uveitis, dermatologic manifestations, and metabolic bone disease. 1 Mucosal involvement in the head and neck is unusual, but it has been described in the oral cavity, pharynx, cervical esophagus, nasal cavity, orbit, and middle ear. 2,3 Crohn disease rarely involves the larynx, as only 13 cases of laryngeal Crohn disease have been reported in the literature.…”

Granulomatous Inflammation Causing Severe Supraglottic Edema and Airway Obstruction in a Pediatric Patient

“…4 Crohn disease is another cause of granulomatous inflammation that, while rare, can present with laryngeal manifestations. [5][6][7][8][9][10] Due to this patient's family history of inflammatory bowel disease and lack of other identifiable etiology, this was presumed to be the most likely diagnosis. Fecal calprotectin, a nonspecific marker of bowel inflammation, was notably positive and there were some gross signs of erosion identified on upper and lower GI endoscopy, but definitive histologic signs of inflammatory bowel disease were not found.…”

“…9 Another patient presented with symptoms of upper airway obstruction due to granulomatous supraglottic inflammation and was then found to have histologic evidence of Crohn disease in the terminal ileum, despite relatively normal gross appearance on GI endoscopy and lack of GI symptoms. 7 Ahmed et al reports a case of a pediatric patient who presented with granulomatous inflammation of the trachea requiring urgent tracheostomy, without GI symptoms, who was subsequently given a diagnosis of Crohn after colonoscopy. 14 Laryngeal manifestations of Crohn disease seem to respond to treatment of the GI disease, though particular attention should be given to stabilization of the airway.…”

Nonasthmatic eosinophilic bronchitis in an ulcerative colitis patient – a putative adverse reaction to mesalazine: A case report and review of literature

“…Pathology shows nonspecific findings (some findings may coexist)[ 11 ]: Inflammatory infiltrate dominated by lymphocytes or neutrophils[ 12 ], some authors specifically noted the relative absence of eosinophils[ 13 ]; squamous metaplasia; ulceration; and granulation tissue with fibrin rich exudate and re-epithelialization[ 14 ]; granuloma formation is possible[ 15 ], thus prompting the differential diagnosis with sarcoidosis, tuberculosis, amyloidosis and granulomatosis with polyangiitis. Corticoids, either inhaled[ 16 ] or systemic, and other immunomodulator agents are considered effective, but scarring and severe tracheal stenosis may develop[ 14 , 17 ].…”