Crohn's disease and vitamin B12 metabolism

Lambert, Daniel; Benhayoun, S.; Adjalla, Charles; Gelot, M. A.; Renkes, P; Felden, F.; Gérard, P.; Belleville, F.; Gaucher, P; Guéant, Jean‐Louis; Nicolas, Jean‐Pierre

doi:10.1007/bf02088567

Cited by 30 publications

(25 citation statements)

References 26 publications

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“…The 12 studies included 2570 individuals in total, with 1086 IBD patients and 1484 controls [15,16,22,23,24,25,26,27,28,29,30,31]. The detailed results are expressed in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…Among the 12 studies, the folate concentration in the study by Kuroki et al [24] was excluded because it was detected in red blood cells. Folate and vitamin B12 were detected via chemiluminescence immunoassays in three studies [15,22,28], radioimmunoassays in four studies [23,24,25,30], ELISA in two studies [26,31], a specific immunochemical method in one study [29], and the IMx assay in one study [16]. Three studies did not include the mean age of patients and controls [15,16,23], and one study included the median age of patients and controls [23].…”

Section: Resultsmentioning

confidence: 99%

“…Folate and vitamin B12 were detected via chemiluminescence immunoassays in three studies [15,22,28], radioimmunoassays in four studies [23,24,25,30], ELISA in two studies [26,31], a specific immunochemical method in one study [29], and the IMx assay in one study [16]. Three studies did not include the mean age of patients and controls [15,16,23], and one study included the median age of patients and controls [23]. Of the 12 included studies, six studies were conducted in Asia [15,22,24,26,28,31], four in Europe [16,23,25,30], one in America [27], and one in Africa [29].…”

Section: Resultsmentioning

confidence: 99%

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Associations between Folate and Vitamin B12 Levels and Inflammatory Bowel Disease: A Meta-Analysis

et al. 2017

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Background: Inflammatory bowel disease (IBD) patients may be at risk of vitamin B12 and folate insufficiencies, as these micronutrients are absorbed in the small intestine, which is affected by IBD. However, a consensus has not been reached on the association between IBD and serum folate and vitamin B12 concentrations. Methods: In this study, a comprehensive search of multiple databases was performed to identify studies focused on the association between IBD and serum folate and vitamin B12 concentrations. Studies that compared serum folate and vitamin B12 concentrations between IBD and control patients were selected for inclusion in the meta-analysis. Results: The main outcome was the mean difference in serum folate and vitamin B12 concentrations between IBD and control patients. Our findings indicated that the average serum folate concentration in IBD patients was significantly lower than that in control patients, whereas the mean serum vitamin B12 concentration did not differ between IBD patients and controls. In addition, the average serum folate concentration in patients with ulcerative colitis (UC) but not Crohn’s disease (CD) was significantly lower than that in controls. This meta-analysis identified a significant relationship between low serum folate concentration and IBD. Conclusions: Our findings suggest IBD may be linked with folate deficiency, although the results do not indicate causation. Thus, providing supplements of folate and vitamin B12 to IBD patients may improve their nutritional status and prevent other diseases.

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“…The 12 studies included 2570 individuals in total, with 1086 IBD patients and 1484 controls [15,16,22,23,24,25,26,27,28,29,30,31]. The detailed results are expressed in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Associations between Folate and Vitamin B12 Levels and Inflammatory Bowel Disease: A Meta-Analysis

et al. 2017

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“…In relation to the history intake due to malaise and anorexia, the excessive nutrient requirement due to bowel inflammation and the sulfasalaof thrombosis, only 1 of 4 patients with a history of thromboembolic events had the factor V Leiden muta-zine-induced folate malabsorption. The cobalamin status in IBD patients has been reported as either low [73] or tion, but the prevalence of this mutation in patients with thromboembolism (25%) was significantly higher than in normal [74].…”

Section: Antiphospholipidic Antibodies and Inflammatory Bowel Diseasementioning

confidence: 99%

Role of Thrombotic Vascular Risk Factors in Inflammatory Bowel Disease

Koutroubakis

2000

Dig Dis

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Thromboembolic disease is a significant cause of morbidity and mortality in patients with inflammatory bowel disease (IBD). It is recognized that a hypercoagulable state exists in IBD which involves all components of the clotting system. It has been suggested that this hypercoagulable state is closely linked to the disease pathogenesis. Recent studies have shown that genetic defects such as factor V Leiden mutation and C677T methylenetetrahydrofolate reductase polymorphism associated with hyperhomocysteinemia seem to interfere in the thrombotic manifestations of IBD. Acquired factors such as antiphospholipid antibodies could also participate in the development of the thrombotic process. Deficiencies of other anticoagulant factors play a less important role in the thrombosis, and therefore it is not surprising that the results on these factors in IBD are contradictory. In conclusion the resultant gene–gene and gene–environment interactions between risk factors are the key to the understanding of why an IBD patient develops thrombosis at a specific point in time.

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“…The reported prevalence of B12 deficiency in CD ranges from 5.6% to 38% and main causes of this deficiency are ileal resection and ileal disease (activity or fibrosis) [4,5,6,7,8,9,10,11]. …”

Section: Introductionmentioning

confidence: 99%

Oral Cyanocobalamin is Effective in the Treatment of Vitamin B12 Deficiency in Crohn’s Disease

et al. 2017

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Cobalamin deficiency is common in patients with Crohn’s disease (CD). Intramuscular cobalamin continues to be the standard therapy for the deficiency and maintenance treatment in these patients, although oral route has been demonstrated to be effective in other pathologies with impaired absorption. Our aims were to evaluate the efficacy of oral therapy in the treatment of cobalamin deficiency and in long-term maintenance in patients with Crohn’s disease. We performed a multicenter retrospective cohort study that included 94 patients with Crohn’s disease and cobalamin deficiency. Seventy-six patients had B12 deficiency and 94.7% of them normalized their cobalamin levels with oral treatment. The most used dose was 1 mg/day, but there were no significant differences in treatment effectiveness depending on the dose used (≥1 mg/24 h vs. <1 mg/24 h). Eighty-two patients had previous documented B12 deficiency and were treated with oral B12 to maintain their correct cobalamin levels. After a mean follow-up of 3 years, the oral route was effective as maintenance treatment in 81.7% of patients. A lack of treatment adherence was admitted by 46.6% of patients in who the oral route failed. In conclusion, our study shows that oral cyanocobalamin provides effective acute and maintenance treatment for vitamin B12 deficiency caused by CD with or without ileum resection.

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Crohn's disease and vitamin B12 metabolism

Cited by 30 publications

References 26 publications

Associations between Folate and Vitamin B12 Levels and Inflammatory Bowel Disease: A Meta-Analysis

Associations between Folate and Vitamin B12 Levels and Inflammatory Bowel Disease: A Meta-Analysis

Role of Thrombotic Vascular Risk Factors in Inflammatory Bowel Disease

Oral Cyanocobalamin is Effective in the Treatment of Vitamin B12 Deficiency in Crohn’s Disease

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