Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: A double-blind, randomized and placebo-controlled trial

Moshiri, Esmail; Basti, Afshin Akhondzadeh; Noorbala, Ahamad-Ali; Jamshidi, A H; Abbasi, Seyed Hesameddin; Akhondzadeh, Shahin

doi:10.1016/j.phymed.2006.08.006

Cited by 188 publications

(122 citation statements)

References 13 publications

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“…Previous studies supported the poisonous impact of saffron too. Researchers have shown that appetite reduction is considered as a side effect following the treatment by saffron (Moshiri et al, 2006;Noorbala et al, 2005). Mohajeri et al (2008) suggested that significant growth of leukocytes number may be considered as an outcome due to inflammation reactions created in damaged tissues of mice including liver and kidney following the treatment using saffron extract.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding therapeutic characteristics, saffron is beneficial for curing nervous pains, insomnia, paroxysm, asthma, rheumatism, gingivitis, cough, gastric disorders, sleeplessness, uterus chronic hemorrhage, femininity disorders, scarlet fever, influenza and cardiovascular disorders and brain damages (Bisset and Wichtl, 2001;Fatehi et al, 2003;Gainer and Jones, 1975;Mohajeri et al, 2008;Wuthrich et al, 1997). In traditional medicine, saffron has been utilized with various applications such as sexual potential stimulant (Abe and Saito, 2000), anti spasm (Bisset and Wichtl, 2001;Hosseinzadeh and Talebzadeh, 2005) anti depression (Moshiri et al, 2006), sedative and anti inflammation, anti flatulence, regulating menstruation, increasing factor of body transpiration (Abe and Saito, 2000;Abdullaev and Espinosa-Aguirre, 2004;Abdullaev and Ferenkel, 1992;Akhondzadeh et al, 2004;Fatehi et al, 2003;Meistrich et al, 2003;Hosseinzadeh and Talebzadeh, 2005;Mohajeri et al, 2007;2008;Moshiri et al, 2006;Ochiai et al, 2007). Also it has been cleared that this grass improves the memory power and has some removal effects on free radicals.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Saffron on Histomorphometric Changes of Testicular Tissue in Rat

2011

American Journal of Animal and Veterinary Sciences

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Problem statement: Saffron is widely used as a food flavor and has well known medicinal effects. This drug has an effect on steroid and sexual hormones. The aim of this study was investigation of Saffron orally administration on histomorphometric change of testicular tissue in rat. In this experimental study, 40 male rats are used (4 groups and 10 rats in each group). Approach: Animals were received Saffron (50, 100 and 200 mg kg −1 ) daily orally administration, during 28 days. As one group was control (normal saline) and three groups was drug consumer. The testis tissue was sampled after passing of above time and section providing, was stained by H and E. Results: The histomorphometric changes of testicular tissue which include, seminiferous tubules diameter, seminiferous epithelial thickness, interstitial tissue and testicular capsule thickness were studied. Results showed that seminiferous tubules diameter, seminiferous epithelial thickness had significantly decreased (p<0.05) but interstitial tissue thickness had significantly increased (p<0.05) compared with control group. Testicular capsule thickness had not significantly changed. Conclusion: Our results showed that seminiferous tubules diameter, seminiferous epithelial thickness and interstitial tissue thickness in rat testis were significantly changed after Saffron orally administration. This results probably via the reducing of serum testosterone concentration. Effect of Saffron on spermatogenesis index and unfertilization in human needed to be more investigation.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Saffron on Histomorphometric Changes of Testicular Tissue in Rat

2011

American Journal of Animal and Veterinary Sciences

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“…Previous studies have already demonstrated that the ethanol extracts of saffron petal has antidepressant effect in a pre-clinical study (Moshiri et al, 2006), and petroleum ether and dichloromethane fractions of saffron corms produce antidepressant-like effects in behavioral models predictive of antidepressant properties (Wang et al, 2010). It is also reported that a kind of glucoconjugate, isolated from saffron corms and calluses has cytotoxic activity property against tumor cells (Escribano et al, 2000).…”

Section: Research Articlementioning

confidence: 97%

Chemical constituents and bioactivities of the liposoluble fraction from different medicinal parts ofCrocus sativus

Zheng¹,

Li²,

Ma³

et al. 2011

Pharmaceutical Biology

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“…Crocus sativus showed significantly better outcome on the Hamilton depression rating scale and there were no significant differences observed in the two groups in terms of the side effects. 24 Pharmalogical activities of saffron Anti-oxidant activity…”

Section: Clinical Studies On Saffron and Their Constituentmentioning

confidence: 99%

Saffron (Crocus sativus) and its Active Ingredients: Role in the Prevention and Treatment of Disease

Rahmani¹,

Khan²,

Aldebasi³

2017

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Introduction:Crocus sativus is a member of iridaceae family and its use in health management is in practice since ancient time. Additionally, research based on clinical trials and animal models have advocates its role in disease cure without any severe adverse complications. The aim of this study is to summarize the study of saffron and its ingredients based on in vivo and in vitro and role in disease cure and prevention. Materials: This study was designed through the search engines such as Pub Med, Scopus and Google Scholar. The keywords used for the search were mainly focused on Saffron with health benefit and its therapeutics role in different diseases. Result: Saffron stigma is mixture of various components and recent studies have proven that saffron and its active ingredients play a key role in disease management. Moreover, clinical trials based study on the use of saffron and its individual components have confirmed the health promising effects. Conclusion: Although Saffron has potential role in the disease cure and prevention via modulation of anti-oxidant, anti-inflammatory, anti-tumour, anti-microbial and anti-diabetic activity. Furthermore, advanced research is needed to elaborate the role of saffron in health management and its mechanism of action in the modulation of biological activities.

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Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: A double-blind, randomized and placebo-controlled trial

Cited by 188 publications

References 13 publications

Effect of Saffron on Histomorphometric Changes of Testicular Tissue in Rat

Effect of Saffron on Histomorphometric Changes of Testicular Tissue in Rat

Chemical constituents and bioactivities of the liposoluble fraction from different medicinal parts ofCrocus sativus

Saffron (Crocus sativus) and its Active Ingredients: Role in the Prevention and Treatment of Disease

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