Crocin treatment decreased pancreatic atrophy, LOX-1 and RAGE mRNA expression of pancreas tissue in cholesterol-fed and streptozotocin-induced diabetic rats

Bayatpoor, Mohammad Ehsan; Mirzaee, Saeed; Karami, Mohammad; Mohammadi, Mohammad Taghi; Shahyad, Shima; Bahari, Zahra; Sarshoori, Javad Raouf

doi:10.1515/jcim-2019-0117

Cited by 5 publications

(1 citation statement)

References 36 publications

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“…The animals received single intravenous (i.v.) injection of STZ (40 mg/kg) into the tail vein at the start of the experiment for induction of DM (Bayatpoor et al, 2019). The animals with the serum glucose levels of >200 mg/dL were used as the diabetic rats.…”

Section: Experimental Designmentioning

confidence: 99%

Anti-diabetic effects of fullerene C60 nanoparticle mediated by its anti-oxidant activity in the pancreas in type 1 diabetic rats

Bahari

Ranjbar

Namdar

et al. 2022

Braz. J. Pharm. Sci.

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The present study aims to examine the anti-diabetic effects of fullerene C60 nanoparticle, as an anti-oxidant compound, on serum glucose level, body weight, food and water intake, and pancreatic oxidative stress in the rats with type 1 diabetes. Diabetes mellitus was induced by single intravenous injection of streptozotocine (45 mg/kg) into the tail vein of the rats. Four groups of rats were divided as follow: normal, normal treatment, diabetic, and diabetic treatment groups. Normal treatment and diabetic treatment groups received intra-orally fullerene (1 mg/ kg/daily) up to day 60 following streptozotocine injection. Oxidative stress markers in the pancreas were evaluated on day 60 after inducing diabetes mellitus. Injection of streptozotocine significantly increased serum glucose level as well as food and water intake on all experimental days; it decreased body weight on day 60. Streptozotocine increased MDA level and decreased GSH level and SOD activity in the pancreas. Fullerene significantly decreased food and water intake and increased body weight as compared with the diabetic group. Fullerene also could normalize the pancreatic MDA and GSH markers. The present study suggested that fullerene can decrease diabetic symptoms via its anti-oxidant activity in the pancreas in the rats with type 1 diabetes mellitus.

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Section: Experimental Designmentioning

confidence: 99%

Anti-diabetic effects of fullerene C60 nanoparticle mediated by its anti-oxidant activity in the pancreas in type 1 diabetic rats

Bahari

Ranjbar

Namdar

et al. 2022

Braz. J. Pharm. Sci.

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Crocin prevents metabolic syndrome in rats via enhancing PPAR-gamma and AMPK

Algandaby

2020

Saudi Journal of Biological Sciences

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Amelioration of STZ-induced nephropathy in diabetic rats by saffron hydro alcoholic extract

Amri

Alaee

Latifi

et al. 2021

Hormone Molecular Biology and Clinical Investigation

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Objectives Type 1 diabetes is one of the most important causes of microvascular complications such as nephropathy. On other hand, the use of herbal medicines is more affordable and has fewer side effects. Therefore, this study was conducted to assessment the therapeutic effect of saffron in diabetic nephropathy by regulating the expression of CTGF and RAGE genes as well as oxidative stress in rats with type 1 diabetes. Methods In this study, we used 24 Wistar rats in four groups. To induce diabetes, we used a 55 mg/kg.bw dose of streptozotocin intraperitoneally. Type 1 diabetic rats were administered saffron (20 and 40 mg/kg/day) by gavage once daily for 42 days. Finally, serum urea, creatinine, albumin and SOD, MDA levels in kidney tissue were measured using spectrophotometric methods and CTGF and RAGE gene expression in kidney tissue was measured using real-time PCR method. Results Diabetes significantly increases serum FBG, urea, creatinine and decreases albumin (p<0.001). AS well as increased the CTGF and RAGE genes expression, MDA level and decreased the SOD activity in the kidney tissue (p<0.001). Serum urea, creatinine, albumin was significantly ameliorated by saffron (p<0.001). It was shown the saffron significantly decrease the kidney expression CTGF and RAGE genes and MDA level and increased the SOD activity (p<0.001). Also, it was found that the beneficial effects of the saffron were dose-dependent (p<0.05). Conclusions The results of this study suggest that saffron as an adjunct therapy may prevent development and treatment of diabetic nephropathy by regulating the expression of the CTGF and RAGE genes and oxidative stress.

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Crocin treatment decreased pancreatic atrophy, LOX-1 and RAGE mRNA expression of pancreas tissue in cholesterol-fed and streptozotocin-induced diabetic rats

Cited by 5 publications

References 36 publications

Anti-diabetic effects of fullerene C60 nanoparticle mediated by its anti-oxidant activity in the pancreas in type 1 diabetic rats

Anti-diabetic effects of fullerene C60 nanoparticle mediated by its anti-oxidant activity in the pancreas in type 1 diabetic rats

Crocin prevents metabolic syndrome in rats via enhancing PPAR-gamma and AMPK

Amelioration of STZ-induced nephropathy in diabetic rats by saffron hydro alcoholic extract

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