Crocin protects human erythrocytes from nitrite‐induced methemoglobin formation and oxidative damage

Ansari, Firoz Ahmad; Ali, Shaikh Nisar; Mahmood, Riaz

doi:10.1002/cbin.10687

Cited by 5 publications

(1 citation statement)

References 57 publications

(60 reference statements)

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“…These data greatly supports and confirms that both nitrate and nitrite induce oxidative damage in rat erythrocytes. In accordance with this, recent studies [11,51] has reported a decrease in the levels of these enzymes in human erythrocytes treated with nitrite. In addition, it was observed that nitrite increased the activities of acid phosphatase, AMP deaminase, and LDH.…”

Section: T a B L E 1 Erythrocyte Oxidative Damage Biomarkers By Nitrsupporting

confidence: 67%

Nitrate and nitrite in drinking water affect antioxidant enzymes in erythrocytes of rats

Sierra-Campos¹,

Valdez-Solana²,

Campos-Almazán³

et al. 2018

Ukr.Biochem.J.

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D rinking water is derived from two basic sources: surface waters, such as rivers and reservoirs, and groundwater. All water contains natural contaminants, particularly inorganic compounds that arise from the geological strata through which water flows and, to a varying extent, anthropogenic pollution by both microorganisms and chemicals. The quality of drinking water and possible associated health risks vary throughout the world were some regions show high levels of arsenic and fluoride, or contamination by pathogens [1]. There is a number of possible sources of man-made contaminants, some of which are more important than others. Agriculture is another source of chemical contamination. In this case, the most important contaminant is nitrate, which can cause methemoglobinaemia, or blue-baby syndrome, in bottle-fed infants under 3 months of age [2].Comarca Lagunera Region of Mexico is famed as the largest milk-producing area. The Laguna faces a serious problem of over-exploitation and contamination of its water sources. Located in a semidesert, it produces cotton, alfalfa, walnut, cattle and goats. Such economic activities, along with the large production of milk and beer, consume the aquifer reserves in the region. As a result, the remaining water supplies are contaminated with arsenic, nitrates and other contaminants [3], an important factor for health problems in hundreds of people in the local communities.

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Section: T a B L E 1 Erythrocyte Oxidative Damage Biomarkers By Nitrsupporting

confidence: 67%