Crocin may be useful to prevent or treatment of alcohol induced neurodegeneration and neurobehavioral sequels via modulation of CREB/BDNF and Akt/GSK signaling pathway

Motaghinejad, Majid; Safari, Sepideh; Feizipour, Saba; Sadr, Samira

doi:10.1016/j.mehy.2019.01.017

Cited by 16 publications

(6 citation statements)

References 73 publications

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“…Crocin, as a typical flavonoid, has antiviral, hypoglycemic, hypotensive, immunomodulatory, and cardiovascular protective activities [39][40][41]. In recent years, studies have shown that crocin has protective effects against alcoholinduced neurological damage in mice.…”

Section: Neural Plasticitymentioning

confidence: 99%

Crocin Alleviates Pain Hyperalgesia in AIA Rats by Inhibiting the Spinal Wnt5a/β-Catenin Signaling Pathway and Glial Activation

Wang

et al. 2020

Neural Plasticity

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At present, most of the drugs have little effect on the pathological process of rheumatoid arthritis (RA). Analgesia is an important measure in the treatment of RA and is also one of the criteria to determine the therapeutic effects of the disease. Some studies have found that crocin, a kind of Chinese medicine, can effectively alleviate pain sensitization in pain model rats, but the mechanism is not clear. Emerging evidence indicates that crocin may inhibit the metastasis of lung and liver cancer cells from the breast by inhibiting Wnt/β-catenin and the Wnt signaling pathway is closely related to RA. Wnt5a belongs to the Wnt protein family and was previously thought to be involved only in nonclassical Wnt signaling pathways. Recent studies have shown that Wnt5a has both stimulatory and inhibitory effects on the classical Wnt signaling pathway, and so, Wnt5a has attracted increasing attention. This study demonstrated that crocin significantly increased the mechanical thresholds of adjuvant-induced arthritis (AIA) rats, suggesting that crocin can alleviate neuropathic pain. Crocin significantly decreased the levels of pain-related factors and glial activation. Foxy5, activator of Wnt5a, inhibited the above effects of crocin in AIA rats. In addition, intrathecal injection of a Wnt5a inhibitor significantly decreased hyperalgesia in AIA rats. This research shows that crocin may alleviate neuropathic pain in AIA rats by inhibiting the expression of pain-related molecules through the Wnt5a/β-catenin pathway, elucidating the mechanism by which crocin relieves neuropathic pain and provides a new way of thinking for the treatment of AIA pain.

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Section: Neural Plasticitymentioning

confidence: 99%

Crocin Alleviates Pain Hyperalgesia in AIA Rats by Inhibiting the Spinal Wnt5a/β-Catenin Signaling Pathway and Glial Activation

Wang

et al. 2020

Neural Plasticity

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“…In the resting state, Mg ++ ions block the Ca ++ channel in NMDA receptors, depolarizing the local membrane; channels change to permeable for calcium ions with the shifts of Mg ++ . In high neuronal activation (e.g., status epilepticus), Ca ++ inflow can cause cell depolarization to play a part in Ca ++ -mediated neuronal damage, leading to cell death ( 125 ).…”

Section: Effect Of Crocin On Brain-related Diseasesmentioning

confidence: 99%

Crocin: Functional characteristics, extraction, food applications and efficacy against brain related disorders

Ali

Kousar

et al. 2022

Front. Nutr.

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Crocin is a bioactive compound that naturally occurs in some medicinal plants, especially saffron and gardenia fruit. Different conventional and novel methods are used for its extraction. Due to some control conditions, recent methods such as ultrasonic extraction, supercritical fluid extraction, enzyme-associated extraction, microwave extraction, and pulsed electric field extraction are widely used because these methods give more yield and efficiency. Crocin is incorporated into different food products to make functional foods. However, it can also aid in the stability of food products. Due to its ability to protect against brain diseases, the demand for crocin has been rising in the pharmaceutical industry. It also contain antioxidant, anti-inflammatory, anticancer and antidepressant qualities. This review aims to describe crocin and its role in developing functional food, extraction, and bioavailability in various brain-related diseases. The results of the literature strongly support the importance of crocin against various diseases and its use in making different functional foods.

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“…During abstinence, neural stem cells proliferate, differentiate, migrate and integrate into existing brain circuits to regenerate new neurons and re-establish the dendritic-axonal connection that contributes to learning [112] , [67] . The longer the period of abstinence, the greater the chance of sustaining a healthy recovery of hippocampal dentate gyrus neurons, mammillary bodies, and return of executive functions including learning, memory, and other forms of cognition [75] , [113] . Thus, abstinence regeneration is likely involved in blocking the pro-inflammatory gene expression and enhancing the high signaling cascades which contribute to the genesis of progenitor cells of neural stem cells, astrocytes, microglia, and oligodendrocytes in the course of trophic brain growth.…”

Section: The Potential Therapeutic Approach To Prevent Neurodegenerationmentioning

confidence: 99%

“…Several transcription factors such as nuclear factor-erythroid 2 (NF-E2) related factor 2 (Nrf2), and peroxisome proliferator-activated receptor-coactivator (PGC-1) are responsible for upregulating the endogenous antioxidant enzyme systems to save the brain from alcohol-induced severe neuronal injury [113] , [116] . Antioxidant enzyme heme oxygenase is thought to be highly associated with AD pathology and upregulated by the Nrf2 transcription factor.…”

Section: The Potential Therapeutic Approach To Prevent Neurodegenerationmentioning

confidence: 99%

Effect of alcohol on the central nervous system to develop neurological disorder: pathophysiological and lifestyle modulation can be potential therapeutic options for alcohol-induced neurotoxication

Pervin

Stephen

2021

AIMS Neuroscience

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The central nervous system (CNS) is the major target for adverse effects of alcohol and extensively promotes the development of a significant number of neurological diseases such as stroke, brain tumor, multiple sclerosis (MS), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS). Excessive alcohol consumption causes severe neuro-immunological changes in the internal organs including irreversible brain injury and it also reacts with the defense mechanism of the blood-brain barrier (BBB) which in turn leads to changes in the configuration of the tight junction of endothelial cells and white matter thickness of the brain. Neuronal injury associated with malnutrition and oxidative stress-related BBB dysfunction may cause neuronal degeneration and demyelination in patients with alcohol use disorder (AUD); however, the underlying mechanism still remains unknown. To address this question, studies need to be performed on the contributing mechanisms of alcohol on pathological relationships of neurodegeneration that cause permanent neuronal damage. Moreover, alcohol-induced molecular changes of white matter with conduction disturbance in neurotransmission are a likely cause of myelin defect or axonal loss which correlates with cognitive dysfunctions in AUD. To extend our current knowledge in developing a neuroprotective environment, we need to explore the pathophysiology of ethanol (EtOH) metabolism and its effect on the CNS. Recent epidemiological studies and experimental animal research have revealed the association between excessive alcohol consumption and neurodegeneration. This review supports an interdisciplinary treatment protocol to protect the nervous system and to improve the cognitive outcomes of patients who suffer from alcohol-related neurodegeneration as well as clarify the pathological involvement of alcohol in causing other major neurological disorders.

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Crocin may be useful to prevent or treatment of alcohol induced neurodegeneration and neurobehavioral sequels via modulation of CREB/BDNF and Akt/GSK signaling pathway

Cited by 16 publications

References 73 publications

Crocin Alleviates Pain Hyperalgesia in AIA Rats by Inhibiting the Spinal Wnt5a/β-Catenin Signaling Pathway and Glial Activation

Crocin Alleviates Pain Hyperalgesia in AIA Rats by Inhibiting the Spinal Wnt5a/β-Catenin Signaling Pathway and Glial Activation

Crocin: Functional characteristics, extraction, food applications and efficacy against brain related disorders

Effect of alcohol on the central nervous system to develop neurological disorder: pathophysiological and lifestyle modulation can be potential therapeutic options for alcohol-induced neurotoxication

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