The purpose of the study was to determine the effectiveness of the Guided Inquiry-based Student Worksheet (LKPD). The method used was a quasi-experiment with the one group pretest and posttest design. The population in this study was the students of grade XII IPA at SMA Negeri 2 Painan for the academic year 2020/2021. The sample in this study was the students from class XII IPA 1 as the experimental class and XII IPA 4 as the control class chosen by using the purposive sampling technique. The instruments used were observation questionnaires, product validation sheets, teacher and student practice sheets, and evaluation questions based on the critical and creative thinking indicators. The results of the analysis of pretest and post-test evaluation questions obtained that the mean of N-gain was 0.4 for critical thinking and Ngain was 0.5 for creative thinking. These two thinking skills had moderate N-gain scores. The results of the critical thinking t test showed that t arithmetic (0.036) < t (0.05) and creative thinking skills t test showed that t arithmetic (0.000) < t (0.05). Thus, it indicates that guided inquiry-based LKPD are effective for improving the students’ critical and creative thinking skills.