Critical role of tumor necrosis factor-α in the early process of wound healing in skin

Ritsu, Masae; Kawakami, Kazuyoshi; Emi, Kazuyuki; Tanno, Hiromasa; Ishii, Keiko; Imai, Yoshimichi; Maruyama, Ryoko; Tachi, Masahiro

doi:10.1016/j.jdds.2016.09.001

Cited by 127 publications

(91 citation statements)

References 10 publications

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“…The result reported here was different from that obtained by Legler and co-workers who found more TNF-α elevation in case of infection which might play an important role in innate immunity and host defense against bacterial, fungal, and parasitic infections [16]. In the present study, TNF-α peak level was achieved at 72 hrs and it was 31.957 pg/ml for the infected wound and the same conclusion was reported by Ritsu and co-workers who showed that TNF-α was detected in wound with peak level of 82 pg/ml on the third day of wound injury [17]. Furthermore, Mori and co-workers concluded a rapid variation in TNF-α concentration and this might be due to its short half-life (14 -18 minutes) [18].…”

Section: Discussionsupporting

confidence: 89%

Estimation of Cytokines Involved in Acute-Phase Wound Infection with Reference to Residence Time of Patients in Hospitals

Al-Jebouri¹,

Al-Mahmood²

2019

MRI

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Background: Cytokines have a major role in mediating immunity as well as inflammation. The main proinflammatory cytokines are activated after injury and implicated in healing interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). High levels of IL-6 are recorded at initial inflammatory response and start decreasing down to eight day of wounding while TNF-α level remained static and IL-1α levels showed a different pattern of change following injury and consequence of infection. Methodology: This study was conducted in Al-Kindy and Al-Wasity hospitals in Baghdad on 200 patients suffering from wounds. One hundred patients were with acute wounds infection and the other 100 patients wounded but without infection and considered as control. Interleukin-1α (IL-1α), interleukin-TNF-α (TNFα) and interleukin-6 (IL-60) were determined utilizing ELISA kit sandwich How to cite this paper: Al-Jebouri, M.M. and Al-Mahmood, B.Y.R. (2019) Estimation of Cytokines Involved in Acute-Phase Wound Infection with Reference to Residence Time of Patients in Hospitals. Modern Research in Inflammation, 8, 1-10.

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Section: Discussionsupporting

confidence: 89%

Estimation of Cytokines Involved in Acute-Phase Wound Infection with Reference to Residence Time of Patients in Hospitals

Al-Jebouri¹,

Al-Mahmood²

2019

MRI

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“…Tumor necrosis factor alpha (TNF-α) is a key pro-inflammatory cytokine involved in the early phase of most inflammatory events in the body. Employing mouse models, the expression of TNF-α at detectable levels was discovered to happen just after wound creation and sees an increase in the first several hours until it reaches a peak within 24 hours after which it returns to the basal level [17]. Vascular endothelial cells, keratinocytes, and fibroblasts are the major sources of TNF-α which cause an initiation of the inflammatory phase of the wound healing by promoting the recruitment of inflammatory leukocytes.…”

Section: Tumor Necrosis Factor-α (Tnf-α)mentioning

confidence: 99%

“…Vascular endothelial cells, keratinocytes, and fibroblasts are the major sources of TNF-α which cause an initiation of the inflammatory phase of the wound healing by promoting the recruitment of inflammatory leukocytes. TNF-α is also involved in the regulation of the activity of fibroblasts, keratinocytes, and vascular endothelial cells as well as in modulating synthesis of extracellular matrix proteins and matrix metalloproteinase [17,18]. Based on diabetic models, an increase in TNF-α level coupled with decrease in IL-10 that has anti-inflammatory properties results in sustained expression of chemokines CXCL2 and CCL2 and leads to continuous infiltration of leucocytes to the injury site.…”

Section: Tumor Necrosis Factor-α (Tnf-α)mentioning

confidence: 99%

Biomarkers of Wound Healing

Agyare¹,

Osafo²,

Boakye³

2019

Wound Healing - Current Perspectives

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The prevalence of conditions that eventually result in poor wound healing abounds as humans advance in age. With the increased possibility of wounds not healing comes a leap in morbidity and mortality with its accompanying socioeconomic impact. It is therefore relevant to understand what accounts for aberrant wound healing and more importantly the molecular markers involved in this pathological state. There are known events associated with the wound healing process, spanning from cellular involvement to the role of specific proteins such as cytokines and growth factors that are significant biomarkers in the wound healing process. This chapter discusses biomarkers relevant to the wound healing process, and these biomarkers go a long way to help identify and stratify nonhealing patients for whom biomarker-guided approaches may be of importance clinically in their management.

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“…In keeping with this finding, the biopsy and IHC analysis contained in this study were also performed within the same time frame. 16 The results of the study showed that the expression of TNF-α decreased with MASE-dose-dependent application. The MASE 50% showed the lowest expression of TNF-α.…”

Section: Discussionmentioning

confidence: 93%

“…Inflammation is a complex physiological process and the role of NF-κB in the inflammatory response cannot be extrapolated from in vitro studies. [15][16][17] In the onset of inflammation, NF-κB promotes pro-inflammatory gene induction and also anti-inflammatory genes. In the nucleus, NF-κB binds to specific DNA targets to form what are known as kβ sites.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effect of Musa acuminata Stem

et al. 2020

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Objective This study was designed to assess the anti-inflammatory effect of Musa acuminata through the expression of tumor necrosis factor-α (TNF-α) and nuclear factor kappa β (NF-κB) after 3 days of application of Musa acuminata stem extract (MASE) gel on oral mucosal wound. Materials and Methods An experimental study with post-test only control group design was conducted. Twenty male Rattus norvegicus (Wistar) were injured on their left buccal mucosa and treated three times a day with MASE gel of varying concentrations: 0% (as control), MASE 25%, MASE 37.5%, and MASE 50%. On day 3, a biopsy was performed on each mucosal wound for later immunohistochemical analysis for the expressions of TNF-α and NF-κB. Results The highest expression of TNF-α was observed in the control group (13.20 ± 1.79), while the lowest was in the treatment group using 50% MASE (6.40 ± 1.14). Meanwhile the comparison between treatment groups did not highlight any significant difference (p > 0.05). The highest expression of NF-κB was observed in the control group (13.20 ± 1.30), whereas the lowest was in the treatment group using MASE 50% (6.40 ± 1.14). NF-κB was significantly lower in the treatment group using MASE 50% when compared with other treatment groups (p < 0.05). Conclusion Application of MASE on mucosal wound reduces the expression of TNF-α and NF-κB at all concentrations. The anti-inflammatory effect of MASE 50% was the strongest one.

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Critical role of tumor necrosis factor-α in the early process of wound healing in skin

Cited by 127 publications

References 10 publications

Estimation of Cytokines Involved in Acute-Phase Wound Infection with Reference to Residence Time of Patients in Hospitals

Estimation of Cytokines Involved in Acute-Phase Wound Infection with Reference to Residence Time of Patients in Hospitals

Biomarkers of Wound Healing

Anti-Inflammatory Effect of Musa acuminata Stem

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