Critical review of the association between perineal use of talc powder and risk of ovarian cancer

Taher, Mohamed Kadry; Farhat, Nawal; Karyakina, Nataliya A.; Shilnikova, Nataliya; Ramoju, Siva; Gravel, Christopher A.; Krishnan, Kannan; Mattison, Donald R.; Wen, Shi-Wu; Krewski, Daniel

doi:10.1016/j.reprotox.2019.08.015

Cited by 20 publications

(12 citation statements)

References 56 publications

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“…The type and number of fibers that could potentially be inhaled during normal use of talcum powder were found to be superimposable on those detected in the lung tissue of a woman who died of mesothelioma. The debate sparked by this paper led to several works focusing on this topic until last year with controversial results [ 35 , 37 , 184 , 215 , 216 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 224 ]. For example, it should be emphasized that no excesses of pleural mesothelioma nor talc pneumoconiosis were found in studies of miners in talc mines [ 177 , 225 , 226 , 227 , 228 ].…”

Section: Discussionmentioning

confidence: 99%

Primary Ovarian Mesothelioma: A Case Series with Electron Microscopy Examination and Review of the Literature

Vimercati

Cavone

Delfino

et al. 2021

Cancers

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Primary ovarian mesothelioma is a rare, aggressive neoplastic disease with a poor prognosis. At onset, the tumor is only rarely limited to the ovaries and usually already widespread in the peritoneum. The rarity of this entity and the difficulties differentiating it from either ovarian carcinoma or peritoneal mesothelioma may lead to frequent misdiagnoses and may raise some concerns about its histogenesis. Thus, reporting such rare cases is fundamental to gain greater awareness of this neoplasm and try to answer unsolved questions. Herein, we described four cases of histological diagnoses of ovarian mesothelioma extrapolated by the regional mesothelioma register of Apulia (southern Italy). In all cases, a detailed medical history was collected according to national mesothelioma register guidelines. A broad panel of antibodies was used for immunohistochemistry to confirm the diagnoses. Moreover, ovarian tissue samples were also examined by transmission and scanning electron microscopy, detecting asbestos fibers and talc crystals in two cases. Because of the few cases described, we reviewed the English literature in the Medline database, focusing on articles about ovarian mesothelioma “misclassification”, “misdiagnosis”, “diagnostic challenge” or “diagnostic pitfall” and on unsolved questions about its histogenesis and possible risk factors.

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Section: Discussionmentioning

confidence: 99%

Primary Ovarian Mesothelioma: A Case Series with Electron Microscopy Examination and Review of the Literature

Vimercati

Cavone

Delfino

et al. 2021

Cancers

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“…However, talc was found to be the main component in powders associated with many cancers. 13 As well, the inhalation of powder containing talc and zinc may worsen some airway disorders, such as asthma, and may be fatal for infants. 8 This study showed that the adsorbent lotion could dry the intertriginous areas evaluated by both dermatologists and patients with high satisfaction.…”

Section: Discussionmentioning

confidence: 99%

A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low‐potency topical corticosteroid in the treatment of intertrigo

Leeyaphan

Varothai

Trakanwittayarak

et al. 2021

J of Cosmetic Dermatology

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Background Intertrigo is an inflammatory skin‐fold condition. Candida infections may occur concurrently or afterward. Topical corticosteroids may reduce inflammation but exacerbate Candida infections. The treatment is contentious. Objective To evaluate the efficacies and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin for the treatment of mild‐to‐moderate intertrigo, relative to 1% hydrocortisone cream. Methods This randomized, double‐blinded study enrolled 40 intertrigo patients. Twice daily, 20 patients applied adsorbent lotion while the remainder used 1% hydrocortisone cream. Efficacy evaluation, skin biophysical measurements, skin tolerability, safety, and visual analog scale (VAS) patient‐satisfaction scores were evaluated at baseline and Week 2. Results The adsorbent lotion showed higher complete cure rates for color, partial epidermal loss, papules/pustules/vesicles/patches, dryness, and scaling than the corticosteroid without statistical significance. Adsorbent lotion demonstrated significantly higher reduction in pruritus than the corticosteroid treatment. Reduction of erythema level using Mexameter and VAS patient‐satisfaction scores were not statistically different between adsorbent lotion and hydrocortisone cream. No adverse effects or superimposed infections were reported. Conclusions The anti‐inflammatory efficacies of adsorbent lotion and low‐potency steroid were equivalent. The lotion was safe and produced excellent pruritus reduction. Patient satisfaction was high.

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“…Recent examples of informative meta-analyses of epidemiological data include analyses of the association between exposure to diesel exhaust and lung cancer (Vermeulen et al, 2014) and analyses of the association between talc and ovarian cancer (Kadry Taher et al, 2019). Vermeulen and colleagues (2014) conducted a meta-analysis of three epidemiological studies of the association between occupational exposure to diesel exhaust emissions in the mining and trucking industries and lung cancer, using elemental carbon as an indicator of exposure to diesel exhaust.…”

Section: Meta-analysismentioning

confidence: 99%

Development of an Evidence-Based Risk Assessment Framework

Krewski

2022

ALTEX

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Assessment of potential human health risks associated with environmental and other agents requires careful evaluation of all available and relevant evidence for the agent of interest, including both data-rich and data-poor agents. With the advent of new approach methodologies in toxicological risk assessment, guidance on integrating evidence from multiple evidence streams is needed to ensure that all available data is given due consideration in both qualitative and quantitative risk assessment. The present report summarizes the discussions among academic, government, and private sector participants from North America and Europe in an international workshop convened to explore the development of an evidence-based risk assessment framework, taking into account all available evidence in an appropriate manner in order to arrive at the best possible characterization of potential human health risks, and associated uncertainty. Although consensus among workshop participants was not a specific goal, there was general agreement on the key considerations involved in evidence-based risk assessment incorporating 21 st century science into human health risk assessment. These considerations have been embodied into an overarching prototype framework for evidence integration that will be explored in more depth in a follow-up meeting.

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Critical review of the association between perineal use of talc powder and risk of ovarian cancer

Cited by 20 publications

References 56 publications

Primary Ovarian Mesothelioma: A Case Series with Electron Microscopy Examination and Review of the Literature

Primary Ovarian Mesothelioma: A Case Series with Electron Microscopy Examination and Review of the Literature

Development of an Evidence-Based Risk Assessment Framework

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