A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low‐potency topical corticosteroid in the treatment of intertrigo

Abstract

Background Intertrigo is an inflammatory skin‐fold condition. Candida infections may occur concurrently or afterward. Topical corticosteroids may reduce inflammation but exacerbate Candida infections. The treatment is contentious. Objective To evaluate the efficacies and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin for the treatment of mild‐to‐moderate intertrigo, relative to 1% hydrocortisone cream. Methods This randomized, double‐blinded study enrolled 40 intertrigo patients. Twice daily, 20 patients applied adsorbent lotion while the remainder used 1% hydrocortisone cream. Efficacy evaluation, skin biophysical measurements, skin tolerability, safety, and visual analog scale (VAS) patient‐satisfaction scores were evaluated at baseline and Week 2. Results The adsorbent lotion showed higher complete cure rates for color, partial epidermal loss, papules/pustules/vesicles/patches, dryness, and scaling than the corticosteroid without statistical significance. Adsorbent lotion demonstrated significantly higher reduction in pruritus than the corticosteroid treatment. Reduction of erythema level using Mexameter and VAS patient‐satisfaction scores were not statistically different between adsorbent lotion and hydrocortisone cream. No adverse effects or superimposed infections were reported. Conclusions The anti‐inflammatory efficacies of adsorbent lotion and low‐potency steroid were equivalent. The lotion was safe and produced excellent pruritus reduction. Patient satisfaction was high.

Rosehip extract and wound healing: A review

“…Beyond wound healing, RO has been suggested to have other skin benefits. Leeyaphan et al 20 reported a significant reduction in pruritus in intertrigo patients treated with a lotion containing RO, showing a similar level of patient satisfaction compared to corticosteroid treatment. While these findings indicate the potential versatility of RO in dermatological applications, more research is needed to validate these results.…”

“…In this context, the findings from the studies included in this review may be due to RO's antagonistic effect on TGFβ1, 6 promoting healthier tissue healing and decreasing scar size. Moreover, RO demonstrated anti‐inflammatory and anti‐scarring effects, as indicated by its inhibitory effects on inflammatory mediators such as IL‐1R and IL‐1 6,20,21 . Overall, Lei et al's animal trial demonstrated a notable decrease in scar size in the mice treated with RO compared to the control group.…”

Leaf extracts from Camellia sinensis and Argania spinosa suppress oxidative stress and chemokine release in human 3-dimensional cultured epidermis exposed to PM2.5 collected with cyclonic separation

“…In conclusion, leaf extracts from Camellia sinensis and Argania spinosa protect the epidermis from PM2.5 exposure-induced oxidative stress and subsequent chemokine release. These extracts are considered to be safe in the present practices of use and concentration, although continuous safety evaluation is needed (Becker et al, 2019;Leeyaphan et al, 2022). Therefore, Camellia sinensis and Argania spinosa extracts could be added to a novel cosmetic that protects skin from air pollution.…”

Plants with cosmetic uses

“…(Khallouki et al, 2017). In a randomized controlled trial, an absorbent lotion that has plant ingredients with argan tree oil showed similar anti-inflammatory efficacy on skin-fold conditions to 1% hydrocortisone cream (Leeyaphan et al, 2022).…”

“…It has been shown that topical application of argan oil improved barrier function and increased water‐holding capacity (Khallouki et al, 2017). In a randomized controlled trial, an absorbent lotion that has plant ingredients with argan tree oil showed similar anti‐inflammatory efficacy on skin‐fold conditions to 1% hydrocortisone cream (Leeyaphan et al, 2022).…”