Critical Limb Ischemia: Advanced Medical Therapy

Davies, Mark G.

doi:10.14797/mdcj-8-4-3

Cited by 6 publications

(4 citation statements)

References 67 publications

(31 reference statements)

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“…drug-eluting stents, balloon angioplasty 4,5 ) such as therapeutic schemas (e.g. antiplatelet therapy as an evidence level 1A, treated for hyperlipidemia as an evidence level 1A 7 ) and/or preventions strategies (such as smoking cessation). The adherence to the current guidelines of aspirin, statins, angiotensin-converting enzyme inhibitors (ACEIs), and smoking abstinence varied from 60% (ACEIs) to 84% (aspirin) among patients with vascular disease.…”

Section: Discussionmentioning

confidence: 99%

“…15 Davies showed that smoking exacerbates the existing risk factors and had a negative infl uence on the evolution of the pathology and even its response to treatment. 7 The problem still remains because it is hard for subjects to quit smoking and even if they quit, they do it in the late stages of the disease and this makes no instant impact on the disease's prognosis. No differences between groups were observed in regard of presence of comorbidities (diabetes, arterial blood hypertension, cardiac ischemia, and/or rhythm disorders) (P > 0.6, Table 2).…”

Section: Discussionmentioning

confidence: 99%

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Demographic and Comorbidity Pattern of Patients with Critical Limb Ischemia

et al. 2017

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Aim: The present study aimed at identifying the pattern of patients with critical limb ischemia (CLI) compared with those with peripheral arterial occlusive disease (PAOD). Materials and methods: A four-year retrospective study was conducted with patients hospitalized in the Second Surgical Clinic at the Emergency County Hospital Cluj-Napoca. The medical charts of patients with PAOD (n=466) and CLI (n=223) were reviewed and data were collected. Results: The study included 689 patients; mean age 67 years for PAOD patients and 65 years for CLI patients. A significantly higher percentage of patients were male in both groups (79.25%, P < 0.0001). Most of the patients in both groups had received at least a secondary education (P < 0.0001). Most of the subjects in both groups were smokers (>71.30%) with no difference between groups (P = 0.566). No significant differences were found between the groups in comorbidities (diabetes, arterial blood hypertension, cardiac ischemia, rhythm disorders, P > 0.05). There were more CLI patients that were overweight than overweight patients with PAOD (P = 0.0004). High serum cholesterol (>200 mg/dL) and triglycerides (>150 mg/dL) levels were found in the CLI group (P < 0.05). Age was identified as a risk factors for amputation (OR = 1.03, 95%Cl [1.01−1.05], P = 0.0012). Conclusions: The profile of a patient with critical limb ischemia and peripheral arterial occlusive disease is a 65-67-year-old male smoker with at least a secondary education. The CLI patient is overweight with pathological serum levels of cholesterol and triglycerides.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Demographic and Comorbidity Pattern of Patients with Critical Limb Ischemia

et al. 2017

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“…Nevertheless, further well-designed large randomized controlled trials with low risk of bias are necessary to evaluate the actual outcomes of this therapeutic method and can prove its efficiency and safety for the treatment of CLI. 1,9,11,12 Arterial revascularization is accepted as the cornerstone of treatment to prevent extremity loss, and both open vascular surgery and endovascular therapy have a critical role in the treatment of patients with CLI. 1,7,8,[12][13][14][15] In this paper, the current literature was reviewed, and an overview of arterial revascularization for the treatment of CLI was made.…”

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confidence: 99%

Current Status of Arterial Revascularization for the Treatment of Critical Limb Ischemia in Infrainguinal Atherosclerotic Disease

et al. 2018

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Critical limb ischemia (CLI) is the most severe form of peripheral arterial disease (PAD) that may result in limb loss and even death; thus, the fast and proper treatment should be employed as earlier as possible to prevent these catastrophic consequences. Arterial revascularization is almost always an indispensable treatment option for CLI. Although both endovascular and surgical revascularization procedures have an important role, nowadays, the hybrid revascularization as a combination of these revascularization procedures has also gained increasing popularity in the treatment of patients with CLI. This review provides an update on the arterial revascularization strategies for the treatment of CLI.

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“…3 Diabetic macroangiopathy and local microcirculatory disturbances are major causes of lower limb ischemia. [4][5][6] In addition, diabetic neuropathy may occur, resulting in arteriovenous shunting that further impairs the blood supply of the lower limbs.…”

mentioning

confidence: 99%