Critical Illness Associated Fatal Hypoglycemia in a Nondiabetic Male

Toor, Amit; Toor, Anika; Krishnamurthy, Mahesh

doi:10.1155/2019/4790320

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…Furthermore, severe cardiac failure and hepatic congestion may contribute to lower glucose output from the liver and reduce its intestinal absorption. While hypoglycemia in sepsis and adrenal insufficiency develops due to increased serum cortisol levels [4]. In literature, hypoglycemia in sepsis is often related to strict glycemic control protocols for stress hyperglycemia [23][24][25][26][27].…”

Section: Concurrent Illness (Renal Hepatic or Cardiac Failure Sepsis)mentioning

confidence: 99%

“…Hypoglycemia is defined as a low plasma glucose level of less than 50 mg/dL, thus exposing the subject to potential harm. It is associated with several signs-palpitation, sweating, tremors (adrenergic response), dysarthria, confusion, epilepsy, visual disturbances, and coma (neuroglycopenic response) [2][3][4]. These affect patients' quality of life and can even increase the risk of death, particularly in diabetic patients.…”

Section: Introductionmentioning

confidence: 99%

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Causes of Hypoglycemia

Abu-Odeh¹,

Alnatour²,

Fino³

2022

Basics of Hypoglycemia

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Blood glucose levels may vary during the day, when this variation goes below a specific limit, hypoglycemia occurs. Hypoglycemia is often associated with reductions in quality of life and even the risk of death. Moreover, hypoglycemia is correlated with physical and/or psychological morbidity. It is usually a result of the complex interaction between hyperinsulinemia and the compromised physiological and behavioral responses attempting to reduce glucose levels. Nevertheless, several conditions can cause hypoglycemia, both in diabetic and non-diabetic patients. Mutually, diabetic and non-diabetic hypoglycemia is common in terms of several medications, alcohol ingestion, critical illnesses, and non-B cell tumors.

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Section: Concurrent Illness (Renal Hepatic or Cardiac Failure Sepsis)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Causes of Hypoglycemia

Abu-Odeh¹,

Alnatour²,

Fino³

2022

Basics of Hypoglycemia

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Differentiation of hypoglycemic states according to their heterogeneity (review and personal observation)

Tykhonova

Barabash

Soldatenko

2020

The Journal of v. N. Karazin Kharkiv National University, Series "Medicine"

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The article is dedicated to the problems of differentiated diagnostics of conditions, which are accompanied by the development of hypoglycemia. In clinical practice hypoglycemic syndrome usually associated with diabetes mellitus and considered as consequences of hypoglycemic treatment but causes of this conditions can be different. In the review possible causes of low blood sugar of endocrine and non-endocrine genesis are discussed, their pathogenetic mechanisms are explained.It is emphasized that often hypoglycemic states remain undiagnosed on the background of existing severe somatic pathology, while they can be the cause of deterioration, coma, and sometimes even death of the patient. Among the causes of hypoglycemic states of non-endocrine origin, malignant tumors occupy a special place, as illustrated by the clinical case from personal experience presented in the article.Analyzing this medical history, it should be noted that not always the diagnosis, which seemed obvious at first, is confirmed after a thorough examination of the patient. In addition, the genesis of hypoglycemic seizures often cannot be established as quickly as in our clinical case, especially in oncologic pathology. It may be due to the small size of the malignancy, difficult availability of the tumor for imaging by instrumental methods and other factors. Numerous diagnostic algorithms for determining the cause of hypoglycemic states have been described in the literature, but each of the following algorithms only complements the previous one, taking into account the results of new clinical trials. The article emphasizes that strict adherence to modern guidelines for the management of patients with hypoglycemia will not only promote the timely establishment of the etiological factor of this condition and adequate treatment of the underlying disease, but also improve the quality and sometimes save the patient’s life.

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Critical Illness Associated Fatal Hypoglycemia in a Nondiabetic Male

Cited by 2 publications

References 16 publications

Causes of Hypoglycemia

Causes of Hypoglycemia

Differentiation of hypoglycemic states according to their heterogeneity (review and personal observation)

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