Critical design parameters to develop biomimetic organ-on-a-chip models for the evaluation of the safety and efficacy of nanoparticles

Abdelkarim, Mahmoud; Abdelkader, Yasmin; Abostait, Amr

doi:10.1080/17425247.2023.2152000

Cited by 9 publications

(6 citation statements)

References 182 publications

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“…These changes include the uptake of NPs by cells and the viability of the cell culture after NP exposition. 22…”

Section: Resultsmentioning

confidence: 99%

“…These changes include the uptake of NPs by cells and the viability of the cell culture after NP exposition. 22 Cell integrity and morphology were monitored after GO and FLG exposure to determine whether the presence GO and FLG aggregates affected the plasma membrane integrity or cytoskeleton organisation. The monolayer remained intact after GO and FLG exposure in both static and fluid flow models, thus allowing us to conclude that, at low concentrations, there appears to be no mechanical damage under fluid flow conditions (Fig.…”

Section: Go and Flg Exposure Assaysmentioning

confidence: 99%

“…19–21 Thus, OOC appears to be an excellent instrument to avoid nanoparticle precipitation and to develop specific models recreating specific conditions. 22,23…”

Section: Introductionmentioning

confidence: 99%

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A microphysiological system for handling graphene related materials under flow conditions

Lacueva-Aparicio,

González,

Remacha

et al. 2024

Nanoscale Horiz.

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“…These changes include the uptake of NPs by cells and the viability of the cell culture after NP exposition. 22…”

Section: Resultsmentioning

confidence: 99%

Section: Go and Flg Exposure Assaysmentioning

confidence: 99%

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A microphysiological system for handling graphene related materials under flow conditions

Lacueva-Aparicio,

González,

Remacha

et al. 2024

Nanoscale Horiz.

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“…The biocompatibility of the biomimetic NPs synthesized through different methods from various sources must be clarified before clinical translation ( 27 , 80 , 81 ). Even though CM-coated NPs eliminate problems associated with conventional free drugs and nanocarriers, such as the administration of free therapeutic molecules.…”

Section: Biocompatibility Of the Biomimetic Npsmentioning

confidence: 99%

Implications of biomimetic nanocarriers in targeted drug delivery

et al. 2023

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Nanomaterials and nanostructures have shown fascinating performances in various biomedicine fields, from cosmetic to cancer diagnosis and therapy. Engineered nanomaterials can encapsulate both lipophilic and hydrophilic substances/drugs to eliminate their limitations in the free forms, such as low bioavailability, multiple drug administration, off-target effects, and various side effects. Moreover, it is possible to deliver the loaded cargo to the desired site of action using engineered nanomaterials. One approach that has made nanocarriers more sophisticated is the “biomimetic” concept. In this scenario, biomolecules (e.g., natural proteins, peptides, phospholipids, cell membranes) are used as building blocks to construct nanocarriers and/or modify agents. For instance, it has been reported that specific cells tend to migrate to a particular site during specific circumstances (e.g., inflammation, tumor formation). Employing the cell membrane of these cells as a coating for nanocarriers confers practical targeting approaches. Accordingly, we introduce the biomimetic concept in the current study, review the recent studies, challenge the issues, and provide practical solutions.

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“…Omics includes a variety of sub-disciplines, including genomics, transcriptomics, metabolomics, and proteomics, among others, to provide a complete picture of the molecular landscape. 1,2 The goal of omics is to acquire a comprehensive comprehension of intricate biological mechanisms at the molecular scale, thereby offering insights beyond the scope of conventional methodologies. This multidisciplinary approach explores the composition, structure, function, and interactions of specific molecules, creating a more holistic perspective of biological systems.…”

Section: Introductionmentioning

confidence: 99%