Critical analysis of the Helicobacter pylori-infection leading role in the development of gastroduodenal diseases

Tsimmerman, Y. S.

doi:10.32756/0869-5490-2019-2-19-27

Cited by 7 publications

(2 citation statements)

References 13 publications

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“…According to some data, almost 70–80% of the population is infected. Furthermore, the problems of antibiotic resistance and the inefficiency of eradication therapy remain highly relevant [ 6 , 7 ]. At the same time, when the gastric mucosa is colonized with low-pathogenic strains of H. pylori without pronounced clinical and morphological changes, standard eradication schemes cannot always be considered justified [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Changes in the tissue elements of the gastric mucosa interacting with different strains of <i>Helicobacter pylori</i>, taking into consideration the patient’s genotype

MOLODOZHNIKOVA,

BERESTOVA,

BERECHIKIDZE

et al. 2024

Bioscience of Microbiota, Food and Health

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Section: Introductionmentioning

confidence: 99%

Changes in the tissue elements of the gastric mucosa interacting with different strains of <i>Helicobacter pylori</i>, taking into consideration the patient’s genotype

MOLODOZHNIKOVA,

BERESTOVA,

BERECHIKIDZE

et al. 2024

Bioscience of Microbiota, Food and Health

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“…Only 10% of the population develop clinical manifestations latterly in their lives when getting elderly [ 96 ]. Seventy percent of people who are established to have the bacterium are healthy bacterial carriers, and 5%–10% of those infected develop symptoms of gastritis or PUD [ 97 – 101 ]. Absence of H. pylori -gastritis had been reported [ 102 , 103 ] , and indeed in severe cases and premalignant conditions, a low abundance of H. pylori had been reported [ 104 ].…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori and oral–gut microbiome: clinical implications

Elghannam,

Hassanien,

Ameen

et al. 2023

Infection

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More than half of the world’s population are colonized with H. pylori; however, the prevalence varies geographically with the highest incidence in Africa. H. pylori is probably a commensal organism that has been associated with the development of gastritis, ulcers, and gastric cancer. H. pylori alone is most probably not enough for the development of gastric carcinoma, but evidence for its association with the disease is high and has, therefore, been classified by the International Agency for Research on Cancer as a Class 1 carcinogen. Bacteroidetes and Fusobacteria positively coexisted during H. pylori infection along the oral–gut axis. The eradication therapy required to treat H. pylori infection can also have detrimental consequences for the gut microbiota, leading to a decreased alpha diversity. Therefore, therapy regimens integrated with probiotics may abolish the negative effects of antibiotic therapy on the gut microbiota. These eradication therapies combined with probiotics have also higher rates of eradication, when compared to standard treatments, and are associated with reduced side effects, improving the patient’s compliance. The eradication therapy not only affects gut microbiome but also affects the oral microbiome with robust predominance of harmful bacteria. However, there have been reports of a protective role of H. pylori in Barrett’s esophagus, esophageal adenocarcinoma, eosinophilic esophagitis, IBD, asthma, and even multiple sclerosis. Therefore, eradication therapy should be carefully considered, and test to treat policy should be tailored to specific communities especially in highly endemic areas. Supplementation of probiotics, prebiotics, herbals, and microbial metabolites to reduce the negative effects of eradication therapy should be considered. After failure of many eradication attempts, the benefits of H. pylori eradication should be carefully balanced against the risk of adverse effects especially in the elderly, persons with frailty, and intolerance to antibiotics.

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Features of the inflammatory process in the gastric mucosa with bacterial and viral co-infection

Afanasenkova,

Dubskaya

2024

Rus. J. Evid.-Bas. Gastro.

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Critical analysis of the Helicobacter pylori-infection leading role in the development of gastroduodenal diseases

Cited by 7 publications

References 13 publications

Changes in the tissue elements of the gastric mucosa interacting with different strains of <i>Helicobacter pylori</i>, taking into consideration the patient’s genotype

Changes in the tissue elements of the gastric mucosa interacting with different strains of <i>Helicobacter pylori</i>, taking into consideration the patient’s genotype

Helicobacter pylori and oral–gut microbiome: clinical implications

Features of the inflammatory process in the gastric mucosa with bacterial and viral co-infection

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