CRISPR-mediated base editing in mice using cytosine deaminase base editor 4

Adlat, Salah; Hayel, Farooq; Yang, Ping; Yang, Chen; Oo, Zin Mar; Myint, May Zun Zaw; Sah, Rajiv Kumar; Bahadar, Noor; Al‐Azab, Mahmoud; Bah, Fatoumata Binta; Zheng, Yaowu; Feng, Xuechao

doi:10.1016/j.ejbt.2021.04.010

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Role In Gene Therapy1

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“…It is one of the novel gene therapy strategies that can produce precise base changes from cytidine (C) to thymidine (T). 40 However, the target range of the CBE base editor is still restricted by PAM sequences containing G, T, or A bases. Recently, a more advanced fidelity and efficiency base editor called nNme2-CBE (discovered from Neisseria meningitides) with expanded PAM compatibility for cytidine dinucleotide has been developed in both human cells and rabbits embryos.…”

Section: Role In Gene Therapymentioning

confidence: 99%