Crimean-Congo Hemorrhagic Fever Virus Endemicity in United Arab Emirates, 2019

Camp, Jeremy V.; Kannan, D.; Osman, Babiker Mohammed; Shah, Moayyed Sher; Howarth, Brigitte; Khafaga, Tamer; Weidinger, Pia; Karuvantevida, Noushad; Kolodziejek, Jolanta; Mazrooei, Hessa; Wolf, Nadine D.; Loney, Tom; Nowotny, Norbert

doi:10.3201/eid2605.191414

Cited by 27 publications

(47 citation statements)

References 8 publications

(12 reference statements)

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“…While this paper was in preparation, partial CCHFV S-and M-segment sequences from H. dromedarii ticks and camels from the UAE were published separately. In addition to molecular detection, this study reported that 67 % of sampled camels had CCHFV antibodies, which further supports the view that camels in the region are commonly infected with CCHFV [8]. The partial sequences obtained by Camp et al are almost identical to our current full-length sequences, which also have high sequence identity to previous partial sequences reported from camel ticks in Egypt [20], suggesting that virus strains belonging to the Asia 4 lineage might not only be prevalent in camels and camel ticks in the UAE .…”

Section: Resultssupporting

confidence: 81%

Section: Resultssupporting

confidence: 78%

“…Reported CCHFV seropositivity rates among camels in the United Arab Emirates (UAE) have ranged from 5.3-26 %, with an average of 13.4 % [3,[5][6][7]. Recently, CCHFV RNA prevalence was reported in Hyalomma dromedarii ticks from camels in the UAE and partial genome sequences were recovered [8]. Additionally, neighbouring countries such as Iran and Oman have reported CCHFV RNA prevalence ranging from 5.3-10.2 % in H. dromedarii ticks [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

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Identification of a novel lineage of Crimean–Congo haemorrhagic fever virus in dromedary camels, United Arab Emirates

Khalafalla

Uehara

et al. 2021

Journal of General Virology

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Crimean–Congo haemorrhagic fever virus (CCHFV) is a tick-borne virus causing Crimean–Congo haemorrhagic fever (CCHF), a disease reported to have a high fatality rate in numerous countries. The virus is geographically widespread due to its vector, and numerous wild and domestic animals can develop asymptomatic infection. Serological and limited molecular evidence of CCHFV has previously been reported in Camelus dromedarius (the dromedary, or one-humped camel) in the United Arab Emirates (UAE). In this study, 238 camel samples were screened for CCHFV RNA where 16 camel samples were positive for CCHFV by RT-PCR. Analysis of full-length CCHFV genome sequences revealed a novel lineage in camels from the UAE, and potential reassortment of the M segment of the genome.

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Section: Resultssupporting

confidence: 81%

Section: Resultssupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Identification of a novel lineage of Crimean–Congo haemorrhagic fever virus in dromedary camels, United Arab Emirates

Khalafalla

Uehara

et al. 2021

Journal of General Virology

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“…To our knowledge, camels were never screened for CCHFV-specific antibodies in Mauritania before. Only a limited number of CCHFV seroprevalence studies in camels have been carried out so far [28], with recent findings indicating prevalences of 5.3% in Iran [29], 10.5-14.4% in Niger [30], 21.3% in Sudan [31] and 67% in the United Arab Emirates [32] respectively. Using the newly established camel-specific ELISA, this study revealed a surprisingly high proportion of positive animals (81%).…”

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

Crimean-Congo hemorrhagic fever virus antibody prevalence in Mauritanian livestock (cattle, goats, sheep and camels) is stratified by the animal’s age

Schulz

Barry²,

Stoek

et al. 2021

PLoS Negl Trop Dis

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Crimean-Congo hemorrhagic fever virus (CCHFV) is one of the most widespread zoonotic arthropod-borne viruses in many parts of Africa, Europe and Asia. It belongs to the family of Nairoviridae in the genus of Orthonairovirus. The main reservoir and vector are ticks of the genus Hyalomma. Livestock animals (such as cattle, small ruminants and camels) develop a viremias lasting up to two weeks with absence of clinical symptoms, followed by seroconversion. This study was carried out to assess risk factors that affect seroprevalence rates in different species. In total, 928 livestock animal samples (cattle = 201; sheep = 247; goats = 233; camels = 247) from 11 out of 13 regions in Mauritania were assayed for CCHFV-specific immunoglobulin G (IgG) antibodies using enzyme-linked immunosorbent assays (ELISA) (including a novel indirect camel-IgG-specific CCHFV ELISA). Inconclusive results were resolved by an immunofluorescence assay (IFA). A generalized linear mixed-effects model (GLMM) was used to draw conclusions about the impact of certain factors (age, species, sex and region) which might have influenced the CCHFV antibody status of surveyed animals. In goats and sheep, about 15% of the animals were seropositive, whereas in cattle (69%) and camels (81%), the prevalence rate was significantly higher. On average, cattle and camels were up to twice to four times older than small ruminants. Interestingly, the seroprevalence in all species was directly linked to the age of the animals, i.e. older animals had significantly higher seroprevalence rates than younger animals. The highest CCHFV seroprevalence in Mauritania was found in camels and cattle, followed by small ruminants. The large proportion of positive animals in cattle and camels might be explained by the high ages of the animals. Future CCHFV prevalence studies should at least consider the age of surveyed animals in order to avoid misinterpretations.

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“…Hyalomma asiaticum has been confirmed to be the main vector of CCHFV in Xinjiang, China (Guo et al, 2017; Moming et al, 2018). Hyalomma dromedarii , as a tick species mainly parasitic to camels, has also been demonstrated to carry CCHFV and infect the host (Camp et al, 2020; Moshaverinia and Moghaddas 2015). Strangely enough, H. dromedarii was found in both Left and Right Banner, while CCHFV was detected only in H. dromedarii of females from Alxa Right Banner.…”

Section: Discussionmentioning

confidence: 99%

Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Inner Mongolia, China

Kong

Yan

Liu

et al. 2021

Preprint

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Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne arbovirus that can cause bleeding and death in humans. The mortality rate in humans is between 5 to 30%. The pathogen is prevalent in more than 30 countries in the world. In China, reports of strains of CCHFV have been concentrated in Xinjiang province. However, the CCHFV strain has never been reported in Inner Mongolia, China. This study reports new CCHFV strains, HANM-18, from Hyalomma asiaticum and Hyalomma dromedarii collected in Alxa Left Banner and Alxa Right Banner in Inner Mongolia. Complete sequences of CCHFV were obtained by the nested PCR technique and used for analyzing the identity and evolutionary relationship with other CCHFV strains. Interestingly, our results showed that the S and L fragments of the HANM-18 strain had high degrees of identity with Xingjiang isolate strains, and the M fragment had significant identity with South African isolates. These analyses also indicate that the HANM-18 strain may have been prevalent in northwest Inner Mongolia for many years. This discovery will be helpful in CCHF prevention and control in Inner Mongolia, and it also adds new evidence to the epidemiology of CCHF in China.

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Crimean-Congo Hemorrhagic Fever Virus Endemicity in United Arab Emirates, 2019

Cited by 27 publications

References 8 publications

Identification of a novel lineage of Crimean–Congo haemorrhagic fever virus in dromedary camels, United Arab Emirates

Identification of a novel lineage of Crimean–Congo haemorrhagic fever virus in dromedary camels, United Arab Emirates

Crimean-Congo hemorrhagic fever virus antibody prevalence in Mauritanian livestock (cattle, goats, sheep and camels) is stratified by the animal’s age

Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Inner Mongolia, China

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