Crimean-Congo hemorrhagic fever and pregnancy: Two cases

Abstract

Crimean-Congo Hemorrhagic Fever (CCHF) is a viral zoonosis, transmitted to humans by either: the Hyalomma species of ticks; or by direct contact with body fluids or tissues of infected humans or domestic animals. CCHF can result in death through clinical progression of hemorrhagic fever (1). Tokat Province in Turkey is where CCHF cases are seen at the highest rate.In this article, the cases of two pregnant women are discussed. The women applied in Tokat with a fever and were diagnosed with CCHF. Along with symptomatic treatment, thrombocyte and fresh frozen plasma replacement was performed in one of the patient's cases. Patients were discharged with recovery. The main purpose of this article is to enlighten the progression of CCHF during pregnancy. J Microbiol Infect Dis 2015;5(1): 29-31

Crimean-Congo Hemorrhagic Fever in Pregnancy: Two Cases from Turkey and a Review of the Literature

“…Up to now, overall 15 pregnant CCHF cases have been reported in the literature from Turkey including our cases [7][8][9][10][11] . Only one mother died due to intracerebral hemorrhage.…”

“…Maternal and fetal/ neonatal mortality rates were found to be 6.6% (1/15) and 40% (6/15), respectively in Turkish cases (Table 1). Fetal mortality was Ergonul et al [7] 38 Dizbay et al [8] 36 Survival Survival -+ Present 36 th week Aydemir et al [11] 30 Survival Survival N -No 37 th week Duygu et al [10] 17 found in 3/4 in the first trimester, 4/8 in the first 20 weeks, and 2/7 in the second 20 weeks. Unlike what Pschenichnaya et al [12] reported, fetal mortality was found to be different in terms of pregnancy period in our study.…”

“…Keywords were as follows: "Pregnancy", "Crimean-Congo hemorrhagic fever", "fetus", and "newborn". There were a total of 43 reported cases and 15 of these were from Turkey [7][8][9][10][11][12][13] . One case was excluded due to duplication.…”

“…The others had no complication and reached a healthy full-term gestation and delivered healthy babies. Duygu et al [10] reported two pregnant women with CCHF, one in the 17 th week and the other in the 20 th week of pregnancy. Both delivered healthy babies.…”

Crimean-Congo Hemorrhagic Fever

“…In a case report of a patient infected with CCHF in week 30 of pregnancy, the baby was born at 37 weeks completely healthy with no signs or symptoms related to the disease [75] . In another report, two pregnant patients in Turkey survived and gave birth to healthy babies by vaginal delivery [76] . A review of pregnant patients reported that maternal mortality was 34% (14/41) and fetal/neonatal mortality was 58.5% (24/41), and the presence of hemorrhage was associated with maternal and fetal mortality [77] .…”