Crevicular alkaline phosphatase activity during the application of two patterns of orthodontic forces

AlSwafeeri, Hani; El-Kenany, Walid; Mowafy, Mohamed; Helmy, Mona

doi:10.1179/1465313314y.0000000121

Cited by 5 publications

(13 citation statements)

References 21 publications

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“…ALP levels increased at TS in continuous retraction forces by NiTi spring as well as in gradually increasing force from 50 cN to 150cN at 2wk, showing a predisposition towards bone deposition. 9 A study in rats supported osteoid deposition in the lacunae on TS in 80-120d. 74 The current review shows peak in ALP levels at 2wk on continuous force application of 150cN, 100g or 150g force 9 , 10 , 14 , 24 , 28 , 45 , with greater levels on TS compared to CS.…”

Section: Discussionmentioning

confidence: 90%

“… 9 A study in rats supported osteoid deposition in the lacunae on TS in 80-120d. 74 The current review shows peak in ALP levels at 2wk on continuous force application of 150cN, 100g or 150g force 9 , 10 , 14 , 24 , 28 , 45 , with greater levels on TS compared to CS. This is followed by fall in ALP levels corresponding to hyalinised tissue removal and initiation of post lag phase.…”

Section: Discussionmentioning

confidence: 90%

“…Few studies had different treatment groups employing variable magnitudes of force. 9 , 11 , 34 , 35 , 36…”

Section: Resultsmentioning

confidence: 99%

“…This is followed by fall in ALP levels corresponding to hyalinised tissue removal and initiation of post lag phase. 9 , 24 Magnitude of force was another determinant of variation in ALP. Decrease in ALP levels seen at 1hr, 1d after intrusion by TMA spring is believed to be caused by heavy forces leading to a hyalinised zone.…”

Section: Discussionmentioning

confidence: 98%

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Effect of orthodontic forces on levels of enzymes in gingival crevicular fluid (GCF): A systematic review

Kapoor

Monga

Kharbanda

et al. 2019

Dental Press J. Orthod.

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Objective: Orthodontic force application releases multiple enzymes in gingival crevicular fluid (GCF) for activation, resorption, reversal, deposition of osseous elements and extracellular matrix degradation. The current systematic review critically evaluated all existing evidence on enzymes in orthodontic tooth movement. Methods: Literature was searched with predetermined search strategy on electronic databases (PubMed, Scopus, Embase), along with hand search. Results: Initial search identified 652 studies, shortlisted to 52 studies based on PRISMA. Quality assessment further led to final inclusion of 48 studies (13 moderately and 35 highly sensitive studies). Primary outcomes are significant upregulation in GCF levels of enzymes-aspartate aminotransferase (AST), alkaline phosphatase (ALP), matrix metalloproteinases (MMPs), lactate dehydrogenase (LDH), β-glucuronidase (βG), tartrate resistant acid phosphatase (TRAP), acid phosphatase (ACP) and down regulation in cathepsin B (Cb). Site specificity is shown by ALP, TRAP, AST, LDH, MMP9 with levels at compression site increasing earlier and in higher quantities compared with tension site. ALP levels are higher at tension site only in retention. A positive correlation of LDH, ALP and AST is also observed with increasing orthodontic force magnitude. Conclusions: A strong evidence of variation in enzymes (ALP, AST, ACP TRAP, LDH, MMPs, Cb) in GCF is found in association with different magnitude, stages and sites of orthodontic force application.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 90%

“…Few studies had different treatment groups employing variable magnitudes of force. 9 , 11 , 34 , 35 , 36…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

See 2 more Smart Citations

Effect of orthodontic forces on levels of enzymes in gingival crevicular fluid (GCF): A systematic review

Kapoor

Monga

Kharbanda

et al. 2019

Dental Press J. Orthod.

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“…A recent publication is highlighting the other aspect of biomarkers such as alkaline phosphatase activity enhanced during increased incremental forces in bone deposition on the tension side during orthodontic treatment. 27 Future studies would aim to explore tight regulations or feedback mechanisms that prevent these mediators from increasing excessively, considered indispensable to avoid any harmful consequences. For example, excessive bone resorption molecule such as local prostaglandin E2 (PGE2) concentration leads to iatrogenic root resorption in rats, 28 or in humans.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Using Different Types of Orthodontic Forces upon the Level of Interleukin II in the Human Gingival Crevicular fluid (Clinical Study)

Blich¹

2015

JDHODT

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The Gingival Crevicular Fluid as a Source of Biomarkers to Enhance Efficiency of Orthodontic and Functional Treatment of Growing Patients

Aguiar

Perinetti

Capelli

2017

BioMed Research International

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Gingival crevicular fluid (GCF) is a biological exudate and quantification of its constituents is a current method to identify specific biomarkers with reasonable sensitivity for several biological events. Studies are being performed to evaluate whether the GCF biomarkers in growing subjects reflect both the stages of individual skeletal maturation and the local tissue remodeling triggered by orthodontic force. Present evidence is still little regarding whether and which GCF biomarkers are correlated with the growth phase (mainly pubertal growth spurt), while huge investigations have been reported on several GCF biomarkers (for inflammation, tissue damage, bone deposition and resorption, and other biological processes) in relation to the orthodontic tooth movement. In spite of these investigations, the clinical applicability of the method is still limited with further data needed to reach a full diagnostic utility of specific GCF biomarkers in orthodontics. Future studies are warranted to elucidate the role of main GCF biomarkers and how they can be used to enhance functional treatment, optimize orthodontic force intensity, or prevent major tissue damage consequent to orthodontic treatment.

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Crevicular alkaline phosphatase activity during the application of two patterns of orthodontic forces

Abstract: The use of gradually increasing orthodontic force induces increased activity of osteoblasts during the initial stage of orthodontic tooth movement compared to that induced by a relatively constant orthodontic force.

Cited by 5 publications

References 21 publications

Effect of orthodontic forces on levels of enzymes in gingival crevicular fluid (GCF): A systematic review

Effect of orthodontic forces on levels of enzymes in gingival crevicular fluid (GCF): A systematic review

The Effect of Using Different Types of Orthodontic Forces upon the Level of Interleukin II in the Human Gingival Crevicular fluid (Clinical Study)

The Gingival Crevicular Fluid as a Source of Biomarkers to Enhance Efficiency of Orthodontic and Functional Treatment of Growing Patients

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