Creutzfeldt-Jakob Disease in Recipients of Corneal Transplants

Abstract

It is likely that these 4 recipients of transplanted corneas had sporadic CJD. Because of the many corneal transplantations performed each year in the United States, occasional cases of sporadic CJD in this population are expected.

Report of the Eye Bank Association of America Medical Review Subcommittee on Adverse Reactions Reported From 2007 to 2014

“…In our study, none of the 3 reported systemic infections were definitively confirmed to be because of the donor tissue. Maddox et al 23 reported the incidence of sporadic CJD cases unrelated to donor tissue, based on a review of 4 cases over a 16-year period, to occur in 1 case every 1.5 years.…”

Descarte de córneas por sorologia positiva do doador no Banco de Olhos do Hospital São Paulo: dois anos de estudo

“…Mesmo tecidos avasculares como a córnea, já demonstraram ser meios de contaminação e transmissão (1) . Há relatos de infecções causadas por bactérias, fungos, vírus e mesmo príons adquiridos por transplante de córnea (1)(2)(3)(4)(5)(6) . A legislação brasileira não permite o uso de tecidos para transplante, cujo doador apresente sorologia positiva para hepatite B, hepatite C ou HIV (7) .…”

A pilot to examine the logistical and feasibility issues in testing deceased tissue donors for vCJD using tonsil as the analyte

“…She had received a corneal graft 18 months before her illness developed from a donor with autopsy-confirmed CJD. A number of other cases of CJD in cornea recipients are likely to be coincidental cases unrelated to the corneal allograft (Maddox et al 2008;Armitage et al 2009). There has been a report of a possible association between CJD and tympanic membrane closure with allograft pericardium (Tange et al 1990), but there were no donor details to suggest that the donor had the disease and the association with this tissue transplant cannot be considered proven.…”