Creation of thixotropic multicomponent alkylamide organogels containing non-volatile oil as potential drug release host materials

Abstract

Multicomponent alkylamide organogels containing non-volatile oils were generated as potential thixotropic host materials for medicinal applications such as ointments.

Low-molecular-weight organogelators as functional materials for oil spill remediation

“…[39][40][41] These mixed systems also formed organogels with a silicone oil (decamethylcyclopentasiloxane) and squalane oil (2, 6, 10, 15, 19, 23-hexamethyltetracosane); thus, they may serve as new oil solidifiers. [37,41,42] …”

Phytosterol‐based oleogels self‐assembled with monoglyceride for controlled volatile release

“…Generally, molecular and crystal engineering concepts could be applied to design and identify new oleogels . Consequently, it is now generally accepted that oleogels are modified by self‐assembly with other molecules via physical or chemical interactions into an extensive mesh network that enhances physical stability and functional characteristics . For example, Bot et al .…”

“…long chain poly‐unsaturated fatty acids, carotenoids, antioxidants and phytosterols) . Briefly, oleogels can provide increasing stability for bioactive compounds, preventing recrystallization or precipitation, and act as controlled delivery systems . The delivery process often relies on the formation of a three‐dimensional network of crystallites and, for the case of gelators based on molecular recognition units, this can be controlled systematically .…”

“…4 Consequently, it is now generally accepted that oleogels are modified by self-assembly with other molecules via physical or chemical interactions into an extensive mesh network that enhances physical stability and functional characteristics. 9,10 For example, Bot et al 11,12 and Sawalha et al 13 reported that the -sitosterol and -oryzanol molecules assembled into curved one-dimensional aggregates via hydrogen bridges, resulting in stable and translucent oleogels of triglyceride oil. Small molecule surfactants, such as lecithin, could also modify the sitosterol-based oleogels by self-assembly with a lower degree of supersaturation.…”

“…15,16 Briefly, oleogels can provide increasing stability for bioactive compounds, preventing recrystallization or precipitation, and act as controlled delivery systems. 2,9 The delivery process often relies on the formation of a three-dimensional network of crystallites and, for the case of gelators based on molecular recognition units, this can be controlled systematically. 1,17,18 Although there are already some applications of oleogels in drug and vaccine delivery, relatively few have current applications in volatile delivery, 3,19 especially for phytosterol-based oleogels.…”