Creation of Experimental Human Nose Model With Lyophilized and Decellularized Bovine Cartilage Xenograft

Demir, Can İlker; Yaşar, Emrah Kağan; Davun, Kıvanç Emre; Gök, Aykut; Uzun, Ceyhun; Alagöz, Murat Şahin

doi:10.1097/scs.0000000000004546

Cited by 3 publications

(10 citation statements)

References 21 publications

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“…After title, abstract and full text review were completed, 17 studies were included for final analysis (Figure 1). [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] Studies included were published from 1984-2021. All studies except for two 20,21 were published after 2003.…”

Section: Resultsmentioning

confidence: 99%

“…One of the two virtual simulators consisted of an interactive computer graphic program, where user decisions Cadaver animal Anatomical dissection of caprine cadaver and human nasal modeling 14 Performance analysis of chicken septal cartilage 24 Human nasal modeling with bovine cartilage and placement on rat dorsum 19 Simulation of physical properties 25 and surgical tasks 27 Human Simulation of surgical experience 23,30 (including IO and PCO osteotomies) 26 & Valuable for teaching and improving confidence in intranasal (1.46) and percutaneous (1.54) osteotomies (both p < 0.0001). 26 influence the subsequent choices presented and projected 1year postoperative appearance, mimicking a real rhinoplasty operative experience with follow-up.…”

Section: Resultsmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Animal nasal modelling 14 Performance analysis of chicken septal cartilage 24 Human nasal modelling with bovine cartilage and placement on rat dorsum 19 Simulation of physical properties 25 and surgical tasks 27 with porcine cartilage  Repeated training opportunity, very low cost and accessible replacement for human cartilage. 14,19,24 Facial validity and increase in confidence among trainees. 27  Variation among models similar to human population and in nasal tips, similar physical properties to human lateral lower cartilage (amenable to 5-0 nylon sutures, no cracking, and similar malleability).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Surgical Training Simulators for Rhinoplasty: A Systematic Review

et al. 2023

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Background: Rhinoplasty training currently follows an apprenticeship model that is largely observational. Trainees have limited experience in performing manoeuvres of this complex surgery. Rhinoplasty simulators can address this issue by providing trainees with the opportunity to gain surgical simulator experience that could improve technical competences in the operating room. Objective: This review amalgamates the collective understanding of rhinoplasty simulators described to date. In accordance with the PRISMA guidelines, PubMed, OVID Embase, OVID Medline and Web of Science databases were all searched for original research on surgical simulators for rhinoplasty education and reviewed by independent reviewers. Articles underwent title and abstract screening, and then relevant articles underwent full-text review to extract simulator data. Results: 17 studies, published between 1984-2021, were included for final analysis. Study participant numbers ranged from 4–24, and included staff surgeons, fellows, residents (PGY1-6), and medical students. Cadaveric surgical simulators comprised 8 studies, of which 3 were with human cadavers, one study was a live animal simulator, two were virtual simulators, and six were 3D models. Both animal and human-based simulators increased the confidence of trainees significantly. Significant improvement in various aspects of rhinoplasty knowledge occurred with implementation of a 3D printed model in rhinoplasty education. Rhinoplasty simulators are limited by a lack of an automated method of evaluation and a large reliance on feedback from experienced rhinoplasty surgeons. Conclusion and Relevance: Rhinoplasty simulators have the potential to provide trainees with the opportunity for hands-on training to improve skill and develop competencies without putting patients in harm's way. Current literature on rhinoplasty simulators largely focuses on simulator development, with few simulators being validated and assessed for utility. For wider implementation and acceptance, further refinement of simulators, validation and assessment of outcomes is required.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

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Surgical Training Simulators for Rhinoplasty: A Systematic Review

et al. 2023

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“…In response to this demand, there have been many studies testing various xenograft materials for nasal reconstruction and rhinoplasty, such as porcine dermal collagen [ 13 ], equine pericardium [ 16 ], porcine small intestine submucosa [ 15 ], and bovine [ 27 , 28 ], porcine [ 29 , 30 ], and caprine [ 31 ] cartilages. Of the several xenograft tissues, decellularized cartilage matrix use has been studied, especially in orthopedic surgery for osteochondral regeneration [ 32 ] and plastic surgery for facial reconstruction [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of equine cartilage for rhinoplasty: a multicenter double-blind non-inferiority randomized confirmatory clinical trial

Chang

Yun

Choi

et al. 2022

Arch Craniofac Surg

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Background: The efficacy and safety of equine cartilage as a competent xenograft material for rhinoplasty were evaluated and compared to the outcomes of rhinoplasty using silicone implants.Methods: We performed a multicenter, double-blind, non-inferiority, and randomized confirmatory study. Fifty-six patients were randomized 1:1 to the study group (using MegaCartilage-E) and control group (using silicone implants). The Rhinoplasty Outcome Evaluation (ROE) score, photo documentation, Global Aesthetic Improvement Scale (GAIS), and adverse event data were obtained until 12 months after surgery. The primary efficacy, which is the change in ROE score 6 months after surgery, was assessed in the modified intention-to-treat set. The secondary efficacy was evaluated in the per-protocol set by assessing the change in ROE score 6 and 12 months after surgery and nasofrontal angle, the height of the nasion, and GAIS 1, 6, and 12 months after surgery.Results: The change in ROE score of the study group was non-inferior to that of the control group; it increased by 24.26 ± 17.24 in the study group and 18.27 ± 17.60 in the control group (p = 0.213). In both groups, all secondary outcome measures increased, but there was no statistical difference. In the safety set, treatment-emergent adverse events occurred in 10 patients (35.71%) in the study group and six patients (21.43%) in the control group (p = 0.237). There were 13 adverse device events in the study group and six adverse device events in the control group (p = 0.515).Conclusion: Processed equine cartilage can be used effectively and safely as xenograft material for rhinoplasty.

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The Effect of Anchoring the Columellar Strut Graft to the Lateral Crural Steal Suture in Patients With a Low Nasal Tip: A New Technique

Çetiner¹

2019

Journal of Craniofacial Surgery

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Objective: The achievement of consistently superior results in rhinoplasty is difficult. This study aimed to evaluate the effect of anchoring the columellar strut graft to the thread of the lateral crural steal for nasal tip projection and rotation. Study Design: A retrospective, case-control study. Methods: Two groups were created which consisted of patients who had a history of low nasal tip deformity according to the type of nasal tip surgery in rhinoplasty. In group 1, the lateral crural steal technique with the strut graft was used, whereas in group 2, a new technique, in which the strut graft was anchored to the thread of the lateral crural steal, was used. Patients with low nasal tip deformity due to intrinsic factors such as long lateral crura were included. The effects of the 2 different surgical approaches on facial parameters (the nasolabial angle, nasofacial angle, and Goode ratio) were statistically compared using the Mann–Whitney U test and Student t test, as applicable. Results: Sixty patients were enrolled: half of them were included in group 1 and the other half in group 2. Average postoperative increases of the nasolabial angle score were 10.9 ± 4.72° and 18.76 ± 6.30° in groups 1 and 2, respectively (P < 0.001). Average improvements of the nasofacial angle were 2.33 ± 2.12° and 3.50 ± 2.44° in groups 1 and 2, respectively (P = 0.053). Average postoperative increases of the Goode ratio were 0.02 ± 0.02 in group 1 and 0.04 ± 0.03 in group 2 (P = 0.028). Conclusion: The new technique provided a prominent nasal cephalic rotation with a strong effect on the nasolabial angle and a partial effect on nasal projection.

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Creation of Experimental Human Nose Model With Lyophilized and Decellularized Bovine Cartilage Xenograft

Cited by 3 publications

References 21 publications

Surgical Training Simulators for Rhinoplasty: A Systematic Review

Surgical Training Simulators for Rhinoplasty: A Systematic Review

Efficacy and safety of equine cartilage for rhinoplasty: a multicenter double-blind non-inferiority randomized confirmatory clinical trial

The Effect of Anchoring the Columellar Strut Graft to the Lateral Crural Steal Suture in Patients With a Low Nasal Tip: A New Technique

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