Creatine Kinase and Lactate Dehydrogenase Responses After Upper-Body Resistance Exercise With Different Rest Intervals

Abstract

The purpose of the current study was to compare serum creatine kinase (CK) and lactate dehydrogenase (LDH) concentrations at multiple time points after resistance exercise sessions that incorporated different rest intervals between sets and exercises. Twenty untrained men (18.65+/-0.49 years, 68.30+/-7.98 kg, and 174.4+/-4.80 cm) performed 2 resistance exercise sessions (i.e., 3 sets with 80% 1 repetition maximum for 5 upper-body exercises) with either 1-minute (SEQ1) or 3-minute (SEQ3) rest between sets and exercises. For each session, CK and LDH concentrations were measured before exercise (PRE) and 24, 48, and 72 hours after exercise (24P, 48P, and 72P). Subjects lifted a 24% greater (p<0.05) volume load during SEQ3 than during SEQ1. Within SEQ1, significant differences in CK concentrations were demonstrated between most time points, except between 24P and 72P. Similarly, within SEQ3, significant differences in CK concentrations were demonstrated between most time points, except between 24P and 72P and between 48P and 72P. The CK concentrations were highest at 48P for both sessions. When the CK concentrations were compared between SEQ1 and SEQ3, no significant differences were demonstrated at any time point. Within SEQ1, a significant difference in LDH concentration was demonstrated between 48P and 72P. Within SEQ3, significant differences in LDH concentrations were demonstrated between PRE and 24P and between PRE and 48P. The LDH concentrations were highest at 72P for SEQ1 and at 24P for SEQ3. When the LDH concentrations were compared between SEQ1 and SEQ3, no significant differences were demonstrated at any time point. These results suggest that muscle damage was similar between rest intervals; however, the volume load completed to induce the muscle damage was significantly greater when 3-minute rest intervals were employed. Therefore, when considered relative to the volume load completed, 1-minute rest intervals during resistance exercise may invoke greater muscle damage.

Evaluating the Impact of Omega-3 Supplementation intake on Creatine Kinase index after one Session of Resistance Training in Inactive Individuals

“…However, there turned out to be a significant relationship between 3000 and 4000mg/day doses of Omega-3 and CK levels immediately after exercise training and 24 hours later (P<0.05). based on the findings of Rodrigues et al study (2010), which was conducted to investigate the effect of upper resistance exercise with different rest periods on cell damage, 2 sessions of 3 sets resistance activity, with an intensity of 80% and 5 upper trunk movement, increased the level of CK serum significantly in untrained men, which was consistent with the results of the present study [19]. The results of Jouris et al study (2011), which was conducted to examine the effect of omega-3 fatty acidsupplementation on the inflammatory response to eccentric strength exercise, showed that one week intake of omega-3 fatty acids, modifies inflammatory markers, such as white blood cells, and asthma symptoms, such as the limb, after a session of extrinsic resistance in healthy adult men and women [20]; this is also consistent with the findings of the present study.…”

Effect of Varying Rest Intervals Between Sets of Assistance Exercises on Creatine Kinase and Lactate Dehydrogenase Responses

“…But perhaps a more likely explanation for the lack of an effect of different rest intervals on the appearance of circulating enzymes in the current study is the training status of the subjects (25). Previous studies on the same topic used subjects who were experienced with resistance training, but the rest interval length with which they were accustomed to when training was not recorded (14,21). When timed rest periods are not enforced, both trained and untrained subjects have been found to rest approximately 3 minutes between sets (23).…”

“…A possible explanation for this apparent difference is that Mayhew et al (14) equalized the volume (load x sets x repetitions) completed between the 1--and 3--minute bouts, whereas Ribeiro et al (20) did not, so that subjects completed a greater volume (load x sets x repetitions) for the 3--minute condition. More recently, Rodrigues et al (21) reported similar CK and LDH activity after resistance exercise bouts with either 1--or 3--minute rest intervals between sets, and subjects completed 24% greater volume (load 3 sets 3 repetitions) for the 3--minute bout. Thus, it appears that postexercise CK and LDH activities might be related to both the volume (load x sets x repetitions) completed and the rest interval between sets.…”

Investigation of Electromyography Responses Following Resistance Exercises Done with Different Contractions

“…[6][7][8][9] Bunlardan birinde Rodrigues ve ark., setler ve egzersizler arası farklı dinlenme aralıkları olan direnç egzersizi programları sonrasında belirli zamanlarda kreatin kinaz [creatine kinase (CK)] ve laktat dehidrojenaz (LDH) konsantrasyonlarını karşılaştırmayı amaçlayarak, sedanter erkekleri set ve egzersizler arasında 1-3 dk'lık dinlenme periyodu olan iki farklı direnç egzersizi seansına tabi tutmuşlardır. 24 İki ayrı seans için egzersiz önce-sinde ve 24, 48, 72 saat sonrasında CK ve LDH seviyeleri ölçülmüştür. Denekler 3 dk dinlenme aralıklı egzersizlerde 1 dk'ya göre %24 daha fazla yükleme gerçekleştirmişlerdir.…”

“…Test sonuçları, kas hasarının 3 dk dinlenme uygulandığında, 1 dk dinlenme periyoduna göre daha az kas hasarına uğra-dığını ifade etmişlerdir. 24 Bu araştırma plazma enzim seviyelerinin analizleri ile yapılmış ve 3 dk'lık dinlenmelerin daha az kas hasarına sebebiyet verdiği rapor edilmiştir. Toparlanma periyodunu değerlendirmede y-EMG ölçümünü kullanan mevcut araştırmada, EÖR değerlere en yakın egzersiz sonrası y-EMG değerlerinin 2-4. dk'larda olması dikkate alındığında, sonuçların Rodrigues ve ark.nın çalışmasının sonuçlarıyla örtüştüğü varsayılabilir.…”