Creatine kinase and creatine kinase MB in endurance runners and in patients with myocardial infarction

Abstract

Following a 100 km race creatine kinase (CK) creatine kinase MB (CKMB) activities were serially measured in well trained athletes and compared with enzyme activities in patients with acute myocardial infarction (AMI). The half-time of disappearance of CK (CKt1/2) was 1.75 +/- 0.70 days in runners who trained within the 1st week after the race, and was 0.81 +/- 0.18 days in patients with AMI, P less than 0.005. CKt1/2 in runners was shorter (1.17 +/- 0.28 days) when no training was performed in the first postrace week. CKt1/2 was linearly correlated with age (P less than 0.01) in the runners but not in the patients. CKMBt1/2 was 1.30 and 1.11 days in two runners and 0.56 +/- 0.10 days in patients with AMI (P less than 0.05). In line with histologic and enzymatic findings in skeletal muscle of long distance runners as reported by other workers, our kinetic data provide further evidence that CK and CKMB are released from muscular compartments in runners other than those in patients with AMI.

Plasma Actin, Gelsolin and Orosomucoid Levels after Eccentric Exercise

“…Like in other studies after eccentric exercise, plasma CK activity (Stäubli et al, 1985), as a non-specific marker of EIMD (Brancaccio et al, 2007, 2010), reached the maximal value at 24 h, 48 h, 96 h after training (Kanda et al, 2014; Pliauga et al, 2015) or during exertion in the ultra-marathon runners (Jastrzebski et al, 2015). …”

“…The time points of blood sample collections were determined based on previous experiments (Sorichter et al, 1997; Stäubli et al, 1985). Quadriceps MVC torque was measured at baseline and 24 h post-exercise, and the difference expressed in N⋅m was considered as the torque deficit.…”

“…Numerous indirect markers such as contractile proteins (like myosin heavy chain; Sorichter et al, 2001), isoenzymes, creatine kinase (CK; Stäubli et al, 1985), myoglobin (Munjal et al, 1983; Speranza et al, 1997), aldolase (Kanda et al, 2014), aspartate amino transferase (Lippi et al, 2008; Van der Meulen et al, 1991) and lactate dehydrogenase (Munjal et al, 1983) have been used to quantify EIMD. Highly sensitive protein analytical techniques made it possible to measure several other marker molecules (skeletal troponin I, Sorichter et al, 1997; fast skeletal troponin I, Chapman et al, 2013; α -actin, Martinez-Amat et al, 2005; oxidative stress markers, Bouzid et al, 2014) after intensive exercise.…”

Effect of a leucine-enriched essential amino acids mixture on muscle recovery

“…In this study, peak serum CPK activity was measured 5 days after the exercise loading. In a previous study of endurance runners, total serum CPK activity was markedly elevated 48 hours when they trained during the first week post-exercise36 ) . The increase of CPK following eccentric exercise reached a maximum at 96 hours after exercise, and additional exercise produced only small increases, probably due to accelerated enzymatic clearance37 ) .…”

Break point of serum creatine kinase release after endurance exercise

“…Although numerous studies (3,6,17,19,25) have examined the effects of exercise on serum CK activity under various exercise conditions, few studies address the break point in exercise-induced CK release. Volfinger et al (28) indicated the possibility of a threshold value for CK release, with a "distance" threshold for CK release in horses.…”