Creatine-induced glucose uptake in type 2 diabetes: a role for AMPK-α?

Alves, Christiano Robles Rodrigues; Ferreira, Julio Cesar Batista; Siqueira-Filho, Mário Alves de; Carvalho, Carla Roberta de Oliveira; Lancha, Antônio Herbert; Gualano, Bruno

doi:10.1007/s00726-012-1246-6

Cited by 30 publications

(26 citation statements)

References 24 publications

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“…Another proposed mechanism discussed for increasing muscle mass is the concentration of intracellular water, responsible to enhance the cell hydration state. This effect may be related to increase protein synthesis, besides increases the expression of myogenic transcription factors (26,28,39,40). However, the mechanisms by which creatine exerts beneficial effects in the immobilization are poorly understood.…”

Section: Discussionmentioning

confidence: 99%

Oral creatine supplementation attenuates muscle loss caused by limb immobilization: a systematic review

et al. 2017

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Introduction: Recent studies have pointing creatine supplementation as a promising therapeutic alternative in several diseases, especially myopathies and neurodegenerative disorder. Objective: elucidate the role of creatine supplementation on deleterious effect caused by limb immobilization in humans and rats. Methods: Analyzed articles were searched by three online databases, PubMed, SportDicus e Scielo. After a review and analysis, the studies were included in this review articles on effect of creatine supplementation on skeletal muscle in humans and rat, before, during and after a period of limb immobilization. Results: Studies analyzed demonstrated positive points in use of creatine supplementation as a therapeutic tool to mitigating the deleterious effects of limb immobilization, in humans and rat. Conclusion: The dataset of this literature review allows us to conclude that creatine supplementation may reduce muscle loss and/or assist in the recovery of muscle atrophy caused by immobilization and disuse in rats and humans. Also, we note that further research with better methodological rigor is needed to clarify the mechanisms by which creatine support the recovery of muscle atrophy. Moreover, these effects are positive and promising in the field of muscle rehabilitation, especially after member's immobilization.

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Section: Discussionmentioning

confidence: 99%

Oral creatine supplementation attenuates muscle loss caused by limb immobilization: a systematic review

et al. 2017

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“…It was observed that creatine use has an effect similar to that of sulfonylurea in glycemic control in type 2 diabetic patients (Rocic et al, 1999) and that using creatine may lead to similar results as observed in patients treated with metformin (Bajuk et al, 2001). According to the results Alves et al (2012), this effect of creatine supplementation may be explained by the significant relationship between the increased expression of protein kinase alpha (AMPK-?) and the decreased level of glycated hemoglobin (Hb1Ac), with a consequent increase in the translocation of glucose transporter 4 (GLUT-4).…”

Section: Glucose Uptakementioning

confidence: 97%

Influence of creatine supplementation on indicators of glucose metabolism in skeletal muscle of exercised rats

Araújo

Vieira

Moura

et al. 2013

Motriz: rev. educ. fis.

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Abstract-The purpose of this study was to evaluate the effect of creatine supplementation in the diet on indicators of glucose metabolism in skeletal muscle of exercised rats. Forty Wistar adult rats were distributed into four groups for eight weeks: 1) Control: sedentary rats that received balanced diet; 2) Creatine control: sedentary rats that received supplementation of 2% creatine in the balanced diet; 3) Trained: rats that ran on a treadmill at the Maximal Lactate Steady State and received balanced diet; and 4) Supplemented-trained: rats that ran on a treadmill at the Maximal Lactate Steady State and received creatine supplementation (2%) in the balanced diet. The hydric intake increased and the body weight gain decreased in the supplemented-trained group. In the soleus muscle, the glucose oxidation increased in both supplemented groups. The production of lactate and glycemia during glucose tolerance test decreased in the supplemented-trained group. Creatine supplementation in conjunction with exercise training improved muscular glycidic metabolism of rats.Keywords: somatic index, glucose tolerance, physical activity Resumo-"Influência da suplementação com creatina em indicadores de metabolismo da glucose no músculo esquelético de ratos exercitados." O objetivo deste estudo foi avaliar o efeito da suplementação de creatina na dieta sobre indicadores do metabolismo glicídico musculoesquelético de ratos exercitados. Quarenta ratos Wistar adultos foram divididos em quatro grupos por oito semanas: Controle: receberam dieta balanceada, mantidos sedentários; Controle Creatina: receberam suplementação de creatina (2%) na dieta balanceada, mantidos sedentários; Treinado: correram em esteira na intensidade da máxima fase estável de lactato e receberam a dieta balanceada e grupo Treinado Suplementado: correram em esteira na intensidade da máxima fase estável de lactato e receberam suplementação de creatina (2%) na dieta balanceada. A ingestão hídrica aumentou e o ganho de massa corporal reduziu no grupo treinado e suplementado. No músculo sóleo, a oxidação de glicose aumentou em ambos os grupos suplementados. A produção de lactato e a glicemia durante teste de tolerância à glicose diminuíram no grupo treinado e suplementado. A suplementação com creatina em conjunto com treinamento físico melhorou metabolismo de glicídico muscular dos ratos.Palavras-chaves: índice somático, tolerância à glicose, atividade físicaResumen-"Influencia de la suplementación con creatina sobre indicadores del metabolismo de la glucosa en el músculo esquelético de ratas ejercitadas." El objetivo de este estudio fue evaluar el efecto de la suplementación con creatina en la dieta sobre indicadores del metabolismo de glucosa en el músculo esquelético en ratones ejercitados. Cuarenta ratas macho adultas Wistar se dividieron en cuatro grupos de ocho semanas: Control: recibieron dieta equilibrada, mantenido sedentaria; Control Complementado: La suplementación con creatina recibido (2%) en la dieta equilibrada, sedentaria mantenido; Trained: corrien...

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“…Two double-blind, randomized placebo-controlled trials examined the effects of creatine in patients diagnosed with T2DM Alves et al 2012). In both studies, creatine and placebo groups underwent a moderate intensity aerobic training combined with strengthening exercises.…”

Section: Human Studiesmentioning

confidence: 99%

“…Six studies (Op't Eijnde et al 2001;Newman et al 2003;Derave et al 2003;Van Loon et al 2004;Safdar et al 2008;Gualano et al 2008) used a creatine supplementation loading phase followed by a maintenance phase, and two studies maintained the same low dosage for the entire experiment Alves et al 2012). Five trials tested only creatine (Op't Eijnde et al 2001;Safdar et al 2008;Gualano et al 2008Gualano et al , 2011Alves et al 2012), 2 trials tested creatine plus glucose Van Loon et al 2004), and 1 creatine and/or protein and amino acids . Some trials included moderate intensity aerobic training combined with strengthening exercises Alves et al 2012) or a rehabilitation program after immobilization (Op't Eijnde et al 2001;Derave et al 2003).…”

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confidence: 98%

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Creatine supplementation and glycemic control: a systematic review

et al. 2016

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The focus of this review is the effects of creatine supplementation with or without exercise on glucose metabolism. A comprehensive examination of the past 16 years of study within the field provided a distillation of key data. Both in animal and human studies, creatine supplementation together with exercise training demonstrated greater beneficial effects on glucose metabolism; creatine supplementation itself demonstrated positive results in only a few of the studies. In the animal studies, the effects of creatine supplementation on glucose metabolism were even more distinct, and caution is needed in extrapolating these data to different species, especially to humans. Regarding human studies, considering the samples characteristics, the findings cannot be extrapolated to patients who have poorer glycemic control, are older, are on a different pharmacological treatment (e.g., exogenous insulin therapy) or are physically inactive. Thus, creatine supplementation is a possible nutritional therapy adjuvant with hypoglycemic effects, particularly when used in conjunction with exercise.

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Creatine-induced glucose uptake in type 2 diabetes: a role for AMPK-α?

Cited by 30 publications

References 24 publications

Oral creatine supplementation attenuates muscle loss caused by limb immobilization: a systematic review

Oral creatine supplementation attenuates muscle loss caused by limb immobilization: a systematic review

Influence of creatine supplementation on indicators of glucose metabolism in skeletal muscle of exercised rats

Creatine supplementation and glycemic control: a systematic review

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