Influence of creatine supplementation on indicators of glucose metabolism in skeletal muscle of exercised rats

Araújo, Michel Barbosa de; Vieira, Roberto Carlos; Moura, Leandro Pereira de; Costa, Maria Antônia Ramos; Dalia, Rodrigo Augusto; Sponton, Amanda Christine da Silva; Ribeiro, Carla; Mello, María Alice Rostom de

doi:10.1590/s1980-65742013000400007

Cited by 3 publications

(12 citation statements)

References 34 publications

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“…One study did not mention the sample size . Six studies were controlled (Ferrante et al 2000;Eijnde et al 2001;Ju et al 2005;Souza et al 2006;Op't Eijnde et al 2006;Araújo et al 2013), and 5 were randomized and controlled (Young and Young 2002;Rooney et al 2002;Freire et al 2008;Vaisy et al 2011;Nicastro et al 2012). The median sample size was 63 animals (ranging from 8 to 72).…”

Section: Animal Studiesmentioning

confidence: 99%

“…Only Ferrante et al (2000) studied mice; the other studies used rats (Rooney et al 2002;Young and Young 2002;Ju et al 2005;Souza et al 2006;Op't Eijnde et al 2006;Freire et al 2008;Vaisy et al 2011;Eijnde et al 2001;Nicastro et al 2012;Araújo et al 2013). Eight studies investigated healthy animals (Young and Young 2002;Rooney et al 2002;Ju et al 2005;Souza et al 2006;Freire et al 2008;Eijnde et al 2001;Vaisy et al 2011;Araújo et al 2013), Ferrante et al (2000 used a transgenic mouse model of Huntington's Disease, Op't Eijnde et al (2006) studied Goto-Kakizaki rats (a animal model of inherited T2DM), and Nicastro et al (2012) used rats treated with dexamethasone. Four studies examined the effects of creatine supplementation associated with exercise training on glucose metabolism (Souza et al 2006;Freire et al 2008;Vaisy et al 2011;Araújo et al 2013), and seven studies The search strategy consists of two separate components and each component consists of the key words related to "creatine supplementation" and the key words related to "glucose metabolism" individually.…”

Section: Animal Studiesmentioning

confidence: 99%

“…Eight studies investigated healthy animals (Young and Young 2002;Rooney et al 2002;Ju et al 2005;Souza et al 2006;Freire et al 2008;Eijnde et al 2001;Vaisy et al 2011;Araújo et al 2013), Ferrante et al (2000 used a transgenic mouse model of Huntington's Disease, Op't Eijnde et al (2006) studied Goto-Kakizaki rats (a animal model of inherited T2DM), and Nicastro et al (2012) used rats treated with dexamethasone. Four studies examined the effects of creatine supplementation associated with exercise training on glucose metabolism (Souza et al 2006;Freire et al 2008;Vaisy et al 2011;Araújo et al 2013), and seven studies The search strategy consists of two separate components and each component consists of the key words related to "creatine supplementation" and the key words related to "glucose metabolism" individually. The key words in each component were linked using "OR" as a Boolean function, and the results of the two sections were combined by utilizing the "AND" Boolean in final search adopted creatine supplementation alone (Young and Young 2002;Rooney et al 2002;Ju et al 2005;Souza et al 2006;Op't Eijnde et al 2006;Eijnde et al 2001;Nicastro et al 2012).…”

Section: Animal Studiesmentioning

confidence: 99%

“…The key words in each component were linked using "OR" as a Boolean function, and the results of the two sections were combined by utilizing the "AND" Boolean in final search adopted creatine supplementation alone (Young and Young 2002;Rooney et al 2002;Ju et al 2005;Souza et al 2006;Op't Eijnde et al 2006;Eijnde et al 2001;Nicastro et al 2012). Studies that involved exercise training employed swimming (Souza et al 2006;Freire et al 2008;Vaisy et al 2011) or treadmill running (Araújo et al 2013). The dose of creatine supplementation was described as the percentage of the amount of supplement in the diet (from 1 to 13 %) or as the daily dose (ranging from 300 to 5 g/ kg).…”

Section: Animal Studiesmentioning

confidence: 99%

“…The dose of creatine supplementation was described as the percentage of the amount of supplement in the diet (from 1 to 13 %) or as the daily dose (ranging from 300 to 5 g/ kg). Two studies (Souza et al 2006;Araújo et al 2013) used a "loading stage" protocol (i.e., higher dose during 1 week) followed by a "maintenance stage" (i.e., lower dose after "loading" to maintain creatine levels increased), and the remaining studies maintained the same dose protocol during all the experiments (Ferrante et al 2000;Young and Young 2002;Rooney et al 2002;Ju et al 2005;Op't Eijnde et al 2006;Freire et al 2008;Eijnde et al 2001;Vaisy et al 2011;Nicastro et al 2012). The duration of the interventions ranged from 5 to 94 days.…”

Section: Animal Studiesmentioning

confidence: 99%

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Creatine supplementation and glycemic control: a systematic review

et al. 2016

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The focus of this review is the effects of creatine supplementation with or without exercise on glucose metabolism. A comprehensive examination of the past 16 years of study within the field provided a distillation of key data. Both in animal and human studies, creatine supplementation together with exercise training demonstrated greater beneficial effects on glucose metabolism; creatine supplementation itself demonstrated positive results in only a few of the studies. In the animal studies, the effects of creatine supplementation on glucose metabolism were even more distinct, and caution is needed in extrapolating these data to different species, especially to humans. Regarding human studies, considering the samples characteristics, the findings cannot be extrapolated to patients who have poorer glycemic control, are older, are on a different pharmacological treatment (e.g., exogenous insulin therapy) or are physically inactive. Thus, creatine supplementation is a possible nutritional therapy adjuvant with hypoglycemic effects, particularly when used in conjunction with exercise.

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Section: Animal Studiesmentioning

confidence: 99%

Section: Animal Studiesmentioning

confidence: 99%

Section: Animal Studiesmentioning

confidence: 99%

Section: Animal Studiesmentioning

confidence: 99%

Section: Animal Studiesmentioning

confidence: 99%

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Creatine supplementation and glycemic control: a systematic review

et al. 2016

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Swimming Exercise Modifies Oxidative Stress in Skeletal and Cardiac Muscles of Diabetic Rats

Pio

Orzari²,

Alves

et al. 2020

Preprint

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Abstract Background: Oxidative stress is a key factor in the worsening of diabetes, requiring an increase in the activity of the antioxidant system, culminating in a balance in the body. The aim of the present study was to evaluate the redox state in the skeletal and cardiac muscles in rats induced to diabetes model and submitted to swimming exercise training for 4 weeks. Methods: Wistar rats were separated into the following four groups: untrained control (C); trained control (T); untrained alloxan-induced diabetes (D); trained alloxan-induced diabetes (TD). The animals were submitted to swimming exercise training for 4 weeks. The redox state of skeletal and cardiac muscles was analyzed by TBARS, -SH groups and, H2O2 production as well as by the SOD and Catalase activity. Besides, a histomorphometry analysis was performed in the cardiac muscle in which the total number of cardiomyocytes and the total area of collagen fibers were measured.Results: On the Soleus muscles, the TD group showed increased of H2O2 and Catalase compared to T group; and SOD compared to D group. About the red gastrocnemius, TD group presented higher SOD and lower Catalase relation to D group. Regarding to cardiac muscle, TD group presented lower TBARS than D group, while it was higher in -SH groups and Catalase compared to D group. Moreover, the swimming exercise led to a decrease in hyperglycemia, benefits in pathogenesis and physio-pathogenesis, evidenced by a reduced number of cardiomyocytes and area of collagen fibers. Conclusions: The swimming protocol exercise in diabetic rats was able to control the hyperglycemia, control of oxidative damage and minimize the fibrosis on cardiac muscle in diabetic rats.

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Potential of Creatine in Glucose Management and Diabetes

2021

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Creatine is one of the most popular supplements worldwide, and it is frequently used by both athletic and non-athletic populations to improve power, strength, muscle mass and performance. A growing body of evidence has been identified potential therapeutic effects of creatine in a wide variety of clinical conditions, such as cancer, muscle dystrophy and neurodegenerative disorders. Evidence has suggested that creatine supplementation alone, and mainly in combination with exercise training, may improve glucose metabolism in health individuals and insulin-resistant individuals, such as in those with type 2 diabetes mellitus. Creatine itself may stimulate insulin secretion in vitro, improve muscle glycogen stores and ameliorate hyperglycemia in animals. In addition, exercise induces numerous metabolic benefits, including increases in insulin-independent muscle glucose uptake and insulin sensitivity. It has been speculated that creatine supplementation combined with exercise training could result in additional improvements in glucose metabolism when compared with each intervention separately. The possible mechanism underlying the effects of combined exercise and creatine supplementation is an enhanced glucose transport into muscle cell by type 4 glucose transporter (GLUT-4) translocation to sarcolemma. Although preliminary findings from small-scale trials involving patients with type 2 diabetes mellitus are promising, the efficacy of creatine for improving glycemic control is yet to be confirmed. In this review, we aim to explore the possible therapeutic role of creatine supplementation on glucose management and as a potential anti-diabetic intervention, summarizing the current knowledge and highlighting the research gaps.

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Influence of creatine supplementation on indicators of glucose metabolism in skeletal muscle of exercised rats

Cited by 3 publications

References 34 publications

Creatine supplementation and glycemic control: a systematic review

Creatine supplementation and glycemic control: a systematic review

Swimming Exercise Modifies Oxidative Stress in Skeletal and Cardiac Muscles of Diabetic Rats

Potential of Creatine in Glucose Management and Diabetes

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